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    Hydroxyphenyl cross-linked macromolecular network and applications thereof
    51.
    发明授权
    Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
    羟基苯基交联大分子网络及其应用

    公开(公告)号：US07368502B2

    公开(公告)日：2008-05-06

    申请号：US11198803

    申请日：2005-08-05

    申请人： Anthony Calabro ,  Richard A. Gross ,  Aniq B. Darr

    发明人： Anthony Calabro ,  Richard A. Gross ,  Aniq B. Darr

    IPC分类号： C08L89/00 ,  C08G63/48

    CPC分类号： A61L27/52 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61L27/14 ,  C08G63/81 ,  C08G73/02 ,  C08J3/075 ,  C08L101/14

    摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH. In a preferred embodiment, the macromolecular network is made up of tyramine-substituted hyaluronan molecules that are linked by dityramine bonds to provide a stable, coherent hydrogel with desired physical properties. A method of preparing such a network is also provided.

    摘要翻译： 提供二羟基苯基交联的大分子网络，其可用于人造或组织工程应用，例如人造或合成软骨。 通过首先提供多胺或多羧酸盐大分子（沿着分子长度分别具有多个胺或羧酸基团）制备网络，使该高分子与具有游离羧酸基团的羟基苯基化合物反应 多胺或游离的伯胺基，并且通过碳二亚胺介导的反应途径将羟基苯基化合物取代到大分子上以提供羟基苯基取代的大分子。 然后通过在温度和pH值的代谢条件下分别连接到不同大分子上的两个羟基苯基之间的酶催化的二聚反应将该大分子连接到其它这样的大分子。 在优选的实施方案中，大分子网络由酪胺取代的透明质酸分子组成，其通过二苯胺键连接以提供具有所需物理性质的稳定的，连贯的水凝胶。 还提供了一种制备这种网络的方法。

    New polymers for bitumen modification & other uses
    52.
    发明申请
    New polymers for bitumen modification & other uses 失效
    用于沥青改性和其他用途的新型聚合物

    公开(公告)号：US20080058470A1

    公开(公告)日：2008-03-06

    申请号：US11895626

    申请日：2007-08-27

    申请人： Sara Shaghaghi ,  Reza Shaghaghi

    发明人： Sara Shaghaghi ,  Reza Shaghaghi

    IPC分类号： C08G63/48

    CPC分类号： C08F257/02 ,  C08F265/04 ,  C08F291/00 ,  C08L15/00 ,  C08L23/16 ,  C08L51/003 ,  C08L51/06 ,  C08L95/00 ,  C08L2666/04 ,  C08L2666/02

    摘要： The aim of this invention is to synthesize new polymers which can be used for bitumen modification, oil absorption and other purposes. It was done by synthesizing styrene-modified maleic anhydride complex (SMMA) which has ability to react with all types of polymers and forms nano particles inside them. Indeed it is the formation of nano particles inside the polymers which cause such a great changes in physical, chemical, thermal and mechanical properties. None of the known derivatives of natural rubber or EPDM for examples shows the properties which have seen in this invention. The nature of the polymer determines the end use of the novel products. If the polymer is natural rubber (NR), the resulting novel polymer can be used for bitumen modification. They are compatible with bitumen, melt, react and disperse in bitumen readily without needing to special equipments for blending. The resulting composition is homogenous and demonstrates improved settling and rheological properties at high and low temperatures. If the polymer is ethylene-propylene diene monomer (EPDM), the produced novel polymer behaves like a smart particle and absorbs contaminates like oil selectively from a mixture of oil and water.

    摘要翻译： 本发明的目的是合成可用于沥青改性，吸油等目的的新型聚合物。 通过合成具有与所有类型的聚合物反应并在其内形成纳米颗粒的能力的苯乙烯改性马来酸酐配合物（SMMA）完成。 实际上，在聚合物内部形成纳米颗粒，在物理，化学，热学和机械性质上引起如此巨大的变化。 天然橡胶或EPDM的已知衍生物中没有一个示例显示了本发明中已经看到的性质。 聚合物的性质决定了新产品的最终用途。 如果聚合物是天然橡胶（NR），则所得到的新型聚合物可用于沥青改性。 它们与沥青相容，在沥青中融化，反应和分散，不需要特殊的混合设备。 所得组合物是均匀的，并且在高温和低温下表现出改善的沉降和流变性能。 如果聚合物是乙烯 - 丙烯二烯单体（EPDM），所生产的新型聚合物表现得像一个聪明的颗粒，并从油和水的混合物中选择性地吸收像油一样的污染物。

    Biocompatible crosslinked polymers with visualization agents
    53.
    发明授权
    Biocompatible crosslinked polymers with visualization agents 有权
    生物相容性交联聚合物与可视化试剂

    公开(公告)号：US07332566B2

    公开(公告)日：2008-02-19

    申请号：US11293892

    申请日：2005-12-02

    申请人： Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Peter G. Edelman

    发明人： Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Peter G. Edelman

    IPC分类号： C09F15/00 ,  C07K1/00 ,  C08G63/48 ,  A61K47/30

    CPC分类号： A61K47/34 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/74 ,  A61K47/42 ,  A61L24/106 ,  A61L27/18 ,  A61L27/50 ,  A61L31/06 ,  C07K14/75 ,  C08G63/08 ,  C08G63/912 ,  C08L89/00 ,  G06K7/10831 ,  G06K2207/1016 ,  C08L2666/02

    摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.

    摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子和亲核官能团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。 可交联剂可以与交联聚合物一起包含。

    Dendritic Polymers With Enhanced Amplification and Interior Functionality
    54.
    发明申请
    Dendritic Polymers With Enhanced Amplification and Interior Functionality 有权
    树枝状聚合物具有增强的放大和内部功能

    公开(公告)号：US20070298006A1

    公开(公告)日：2007-12-27

    申请号：US11630044

    申请日：2005-12-21

    申请人： Donald Tomalia ,  Douglas Swanson ,  Baohua Huang ,  Veera Pulgam ,  Sonke Svenson ,  Lori Reyna ,  Michael Zhuravel ,  Abhay Chauhan ,  Cordell DeMattei ,  Joseph Heinzelmann

    发明人： Donald Tomalia ,  Douglas Swanson ,  Baohua Huang ,  Veera Pulgam ,  Sonke Svenson ,  Lori Reyna ,  Michael Zhuravel ,  Abhay Chauhan ,  Cordell DeMattei ,  Joseph Heinzelmann

    IPC分类号： A61K31/785 ,  A61K31/74 ,  A61K47/30 ,  A61K48/00 ,  B05D3/12 ,  C08G63/48 ,  C08G65/329 ,  C08K3/04 ,  C08K3/22 ,  C12N15/87

    CPC分类号： C08G63/46 ,  A01N25/10 ,  A61K8/85 ,  A61K9/0019 ,  A61K9/5146 ,  A61Q15/00 ,  A61Q17/005 ,  C08G83/003 ,  H01M4/86 ,  H01M8/10 ,  Y02P70/56

    摘要： Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.

    摘要翻译： 公开了具有增强的扩增和内部功能的树枝状聚合物。 这些树枝状聚合物通过使用快速，反应性开环化学（或其他快速反应）结合使用分支细胞试剂以受控方式快速和精确地构建树突状结构，一代代，具有更清洁的化学，通常 单一产品，较低的试剂过量，较低的稀释水平，更高的容量方法，更容易缩放到商业尺寸，新的材料范围以及更低的成本。 制备的树枝状组合物具有新颖的内部功能，更高的稳定性（例如，热稳定性和较少的或没有反向的迈克尔反应），并且在较低的代次下达到包封表面密度。 出乎意料的是，多官能分支细胞试剂与多官能核心的这些反应不产生交联材料。 这种树枝状聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强剂，质子清除剂，聚合物，纳米尺寸单体，用于电子显微镜的校准标准品，制备尺寸选择性膜，以及用于在水性制剂中改性粘度的试剂 作为油漆。 当这些树枝状聚合物具有与其表面和/或内部相关的载体材料时，由于树枝状聚合物的独特特征，例如用于药物递送，转染和诊断，这些树枝状聚合物具有携带材料的附加性质。

    Nuclear molecular imaging contrast agent
    57.
    发明申请
    Nuclear molecular imaging contrast agent 审中-公开
    核分子成像对比剂

    公开(公告)号：US20070154390A1

    公开(公告)日：2007-07-05

    申请号：US11449764

    申请日：2006-06-09

    申请人： Huang Chien Liang ,  Hsin-Ell Wang ,  Chin-I Lin ,  Shian-Jy Wang

    发明人： Huang Chien Liang ,  Hsin-Ell Wang ,  Chin-I Lin ,  Shian-Jy Wang

    IPC分类号： A61K51/00 ,  A61K49/10 ,  C08G63/91 ,  C08G63/48

    CPC分类号： A61K51/065

    摘要： A nuclear molecular imaging contrast agent. The nuclear imaging contrast agent comprises a polymer according to the structure of wherein, P is and 1 is not less than 1; D is a C3-30 dendritic moiety having a plurality of oxygen residue; Z is a C3-20 moiety having a plurality of functional groups, wherein the functional groups comprise carbonyl, carboxyl, amine, ester, amide, or chelate group; L is a radioisotope or analyte-specific moiety ; m is not less than two ; and at least one X is an analyte-specific moiety; the other X can be hydrogen atom.

    摘要翻译： 核分子成像造影剂。 核成像造影剂包含根据其结构的聚合物，其中P为1且不小于1; D是具有多个氧残基的C3-30树枝状部分; Z是具有多个官能团的C3-20部分，其中官能团包括羰基，羧基，胺，酯，酰胺或螯合基团; L是放射性同位素或分析物特异性部分; m不小于2; 并且至少一个X是分析物特异性部分; 另外X可以是氢原子。

    Crosslinked polymer compositions
    59.
    发明授权
    Crosslinked polymer compositions 有权
    交联聚合物组合物

    公开(公告)号：US07151135B2

    公开(公告)日：2006-12-19

    申请号：US11078254

    申请日：2005-03-10

    申请人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

    发明人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

    IPC分类号： C08G63/48 ,  C08G63/91 ,  C08G69/48 ,  C08G77/00 ,  C08L89/00 ,  C08F283/00 ,  A61K47/48

    CPC分类号： A61L31/16 ,  A61L24/043 ,  A61L24/08 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/041 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/606 ,  C08B37/0075 ,  C08G65/329 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  Y10S623/90 ,  Y10S623/901 ,  C08L5/16 ,  C08L71/00

    摘要： Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

    摘要翻译： 提供的交联聚合物组合物包括含有共价结合到含有多个亲电子基团的第二合成聚合物的多个亲核基团的第一合成聚合物。 第一合成聚合物优选是已经被修饰以含有多个亲核基团的合成多肽或聚乙二醇，例如伯氨基（-NH 2）或硫醇（-SH）基团。 第二合成聚合物可以是亲水或疏水的合成聚合物，其包含或已被衍生化为含有两个或多个亲电基团，例如琥珀酰亚胺基。 组合物还可包括其它组分，例如天然存在的多糖或蛋白质（例如糖胺聚糖或胶原）和/或生物活性剂。 还公开了使用交联聚合物组合物来实现第一表面和第二表面之间的粘合的方法; 进行组织增生; 以防止手术粘连的形成; 并涂覆合成植入物的表面。

    Hydrophilic polymers with pendant functional groups and method thereof
    60.
    发明申请
    Hydrophilic polymers with pendant functional groups and method thereof 审中-公开

    公开(公告)号：US20060263328A1

    公开(公告)日：2006-11-23

    申请号：US11134820

    申请日：2005-05-19

    申请人： Sang Van ,  Lei Yu

    发明人： Sang Van ,  Lei Yu

    IPC分类号： A61K31/787 ,  C08G63/91 ,  C08G63/48

    CPC分类号： C08G69/26 ,  A61K47/595 ,  A61K47/60 ,  C08G69/02

    摘要： A polymer comprising a recurring unit of the formula (I) is described. In the formula (I), X is selected from the group consisting of —(CH2CH2O)m—CH2CH2— and —CH2CH2CH2O—(CH2CH2O)m—CH2CH2CH2—, wherein m is an integer in the range of 1 to 100; Y is selected from the group consisting of —C*HCH2—, —C*HCH2CH2—, —C*H—NHC(═O)—CH2CH2—, —C*H—NHC(═O)—CH2CH2CH2—, —CH2CH2N*CH2CH2—, —CH2CH2CH2N*CH2CH2CH2—, C2 to C20 alkyl, and C6 to C20 aryl, wherein C* and N* represent atoms to which Z is bonded; and Z is selected from the group consisting of —NHR1, —NH—C(═O)—(CH2)nC(═O)NR1R1, —NH—C(═O)—(CH2)nC(═O)OR1, —(CH2)nC(═O)NR1R2, —(CH2)nC(═O)OR1, —(CH2)nC(═O)SR1, and —(CH2)nNR1R2, wherein n is an integer in the range of 1 to 3, wherein R1 and R2 are each independently selected from the group consisting of hydrogen, C1 to C20 alkyl, C6 to C20 aryl, anticancer drugs, peptides, antibody fragment, lactose, galactose, mannose, transferrin, magnetic resonance imaging agents, succinimyl, and alkali metal.