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    Compositions and methods to treat urinary incontinence
    2.
    发明申请
    Compositions and methods to treat urinary incontinence 有权
    治疗尿失禁的组成和方法

    公开(公告)号：US20090274678A1

    公开(公告)日：2009-11-05

    申请号：US12387256

    申请日：2009-04-30

    申请人： Anthony Calabro ,  Aniq B. Darr ,  Firouz Daneshgari

    发明人： Anthony Calabro ,  Aniq B. Darr ,  Firouz Daneshgari

    IPC分类号： A61K38/44 ,  A61K38/39 ,  A61P13/00 ,  A61K33/40

    CPC分类号： A61K38/39 ,  A61L31/044 ,  A61L2400/06

    摘要： A method is disclosed for treatment of urinary incontinence. The method includes the steps of providing to a person or animal, in the vicinity of a pubo-urethral ligament of the person or animal, a composition including collagen macromolecules that have hydroxyphenyl side groups substituted thereon, which are reacted to form dihydroxyphenyl linkages. In an embodiment, the collagen macromolecules are gelatin macromolecules. In another embodiment, the hydroxyphenyl side groups are tyramine side groups and the dihydroxyphenyl linkages are dityramine linkages. The composition can be injected into a space between a urethra and a pubis of the person or animal wherein the pubo-urethral ligament is disposed in the space. The method is advantageous, for example, based on being minimally invasive.

    摘要翻译： 公开了一种治疗尿失禁的方法。 该方法包括以下步骤：向人或动物在人或动物的尿道韧带附近提供包含其上被羟基苯基侧基取代的胶原大分子的组合物，其被反应以形成二羟基苯基键。 在一个实施方案中，胶原大分子是明胶大分子。 在另一个实施方案中，羟基苯基侧基是酪胺侧基，二羟基苯基键是二联苯胺键。 组合物可以注射到尿道和人或动物的耻骨之间的空间中，其中尿道 - 尿道韧带设置在该空间中。 该方法是有利的，例如，基于微创。

    Hydroxyphenyl cross-linked macromolecular network and applications thereof
    4.
    发明授权
    Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
    羟基苯基交联大分子网络及其应用

    公开(公告)号：US07368502B2

    公开(公告)日：2008-05-06

    申请号：US11198803

    申请日：2005-08-05

    申请人： Anthony Calabro ,  Richard A. Gross ,  Aniq B. Darr

    发明人： Anthony Calabro ,  Richard A. Gross ,  Aniq B. Darr

    IPC分类号： C08L89/00 ,  C08G63/48

    CPC分类号： A61L27/52 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61L27/14 ,  C08G63/81 ,  C08G73/02 ,  C08J3/075 ,  C08L101/14

    摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH. In a preferred embodiment, the macromolecular network is made up of tyramine-substituted hyaluronan molecules that are linked by dityramine bonds to provide a stable, coherent hydrogel with desired physical properties. A method of preparing such a network is also provided.

    摘要翻译： 提供二羟基苯基交联的大分子网络，其可用于人造或组织工程应用，例如人造或合成软骨。 通过首先提供多胺或多羧酸盐大分子（沿着分子长度分别具有多个胺或羧酸基团）制备网络，使该高分子与具有游离羧酸基团的羟基苯基化合物反应 多胺或游离的伯胺基，并且通过碳二亚胺介导的反应途径将羟基苯基化合物取代到大分子上以提供羟基苯基取代的大分子。 然后通过在温度和pH值的代谢条件下分别连接到不同大分子上的两个羟基苯基之间的酶催化的二聚反应将该大分子连接到其它这样的大分子。 在优选的实施方案中，大分子网络由酪胺取代的透明质酸分子组成，其通过二苯胺键连接以提供具有所需物理性质的稳定的，连贯的水凝胶。 还提供了一种制备这种网络的方法。

    Methods to treat urinary incontinence
    5.
    发明授权
    Methods to treat urinary incontinence 有权
    治疗尿失禁的方法

    公开(公告)号：US08410180B2

    公开(公告)日：2013-04-02

    申请号：US12387256

    申请日：2009-04-30

    申请人： Anthony Calabro ,  Aniq B. Darr ,  Firouz Daneshgari

    发明人： Anthony Calabro ,  Aniq B. Darr ,  Firouz Daneshgari

    IPC分类号： A61K47/30

    CPC分类号： A61K38/39 ,  A61L31/044 ,  A61L2400/06

    摘要： A method is disclosed for treatment of urinary incontinence. The method includes the steps of providing to a person or animal, in the vicinity of a pubo-urethral ligament of the person or animal, a composition including collagen macromolecules that have hydroxyphenyl side groups substituted thereon, which are reacted to form dihydroxyphenyl linkages. In an embodiment, the collagen macromolecules are gelatin macromolecules. In another embodiment, the hydroxyphenyl side groups are tyramine side groups and the dihydroxyphenyl linkages are dityramine linkages. The composition can be injected into a space between a urethra and a pubis of the person or animal wherein the pubo-urethral ligament is disposed in the space. The method is advantageous, for example, based on being minimally invasive.

    摘要翻译： 公开了一种治疗尿失禁的方法。 该方法包括以下步骤：向人或动物在人或动物的尿道韧带附近提供包含其上被羟基苯基侧基取代的胶原大分子的组合物，其被反应以形成二羟基苯基键。 在一个实施方案中，胶原大分子是明胶大分子。 在另一个实施方案中，羟基苯基侧基是酪胺侧基，二羟基苯基键是二联苯胺键。 组合物可以注射到尿道和人或动物的耻骨之间的空间中，其中尿道 - 尿道韧带设置在该空间中。 该方法是有利的，例如，基于微创。

    Hydroxyphenyl cross-linked macromolecular network and applications thereof
    8.
    发明授权
    Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
    羟基苯基交联大分子网络及其应用

    公开(公告)号：US08137688B2

    公开(公告)日：2012-03-20

    申请号：US12380469

    申请日：2009-02-27

    申请人： Peter A. Zahos ,  Anthony Calabro ,  Aniq B. Darr ,  Richard A. Gross

    发明人： Peter A. Zahos ,  Anthony Calabro ,  Aniq B. Darr ,  Richard A. Gross

    IPC分类号： C08G63/91 ,  C08G65/48 ,  A61K31/775

    CPC分类号： A61K31/775 ,  A61L27/20 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/38 ,  C08B37/0069 ,  C08B37/0072 ,  C08L5/08 ,  C08L2205/02 ,  C12P19/04 ,  C08L2666/26

    摘要： A synthetic nucleus pulposus is provided that is useful in treatment of degenerative disc disease, augmentation of a degenerate disc, and alleviation of back pain. In an embodiment the synthetic nucleus pulposus comprises hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages. The synthetic nucleus pulposus restores or improves the water-retention capability of the disc. A method of treating an intervertebral disc with the cross-linked hyaluronan macromolecules is also provided. A method of regenerative therapy to address loss of cells of nucleus pulposus of an intervertebral disc based on treatment with the cross-linked hyaluronan macromolecules and mesenchymal stem cells is also provided.

    摘要翻译： 提供了一种合成髓核，可用于治疗退行性椎间盘疾病，增加退行性椎间盘，减轻背部疼痛。 在一个实施方案中，合成髓核包含已经通过二羟基苯基键交联的透明质酸大分子。 合成髓核恢复或提高椎间盘的保水能力。 还提供了用交联的透明质酸大分子治疗椎间盘的方法。 还提供了一种基于用交联透明质酸大分子和间充质干细胞治疗来解决椎间盘髓核的细胞损失的再生治疗方法。