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公开(公告)号：US20080221490A1
公开(公告)日：2008-09-11
申请号：US12043471
申请日：2008-03-06
申请人： Peter A. Zahos
发明人： Peter A. Zahos
CPC分类号： A61H23/0245 , A61B2017/00084 , A61B2017/00119 , A61B2017/00261 , A61B2090/065 , A61H2205/081 , A61N7/02
摘要： A method of repairing an intervertebral disc of a patient's body includes identifying a target area of the intervertebral disc. An ultrasound generator is placed proximate the target area and outside the patient's body. An area temperature at the target area is monitored. Ultrasonic energy is generated with the ultrasound generator within a predetermined energy range. The ultrasonic energy is adjusted in response to the area temperature exceeding a predetermined temperature range. An apparatus for repairing an intervertebral disc of a patient's body is also provided.
摘要翻译： 修复患者身体的椎间盘的方法包括识别椎间盘的目标区域。 将超声波发生器放置在目标区域附近和患者身体外部。 监视目标区域的面积温度。 超声发生器产生超声能量在预定的能量范围内。 响应于区域温度超过预定温度范围来调节超声波能量。 还提供了一种用于修复患者身体的椎间盘的装置。
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2.发明授权公开(公告)号：US08137688B2
公开(公告)日：2012-03-20
申请号：US12380469
申请日：2009-02-27
IPC分类号： C08G63/91 , C08G65/48 , A61K31/775
CPC分类号： A61K31/775 , A61L27/20 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/38 , C08B37/0069 , C08B37/0072 , C08L5/08 , C08L2205/02 , C12P19/04 , C08L2666/26
摘要： A synthetic nucleus pulposus is provided that is useful in treatment of degenerative disc disease, augmentation of a degenerate disc, and alleviation of back pain. In an embodiment the synthetic nucleus pulposus comprises hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages. The synthetic nucleus pulposus restores or improves the water-retention capability of the disc. A method of treating an intervertebral disc with the cross-linked hyaluronan macromolecules is also provided. A method of regenerative therapy to address loss of cells of nucleus pulposus of an intervertebral disc based on treatment with the cross-linked hyaluronan macromolecules and mesenchymal stem cells is also provided.
摘要翻译： 提供了一种合成髓核，可用于治疗退行性椎间盘疾病，增加退行性椎间盘，减轻背部疼痛。 在一个实施方案中，合成髓核包含已经通过二羟基苯基键交联的透明质酸大分子。 合成髓核恢复或提高椎间盘的保水能力。 还提供了用交联的透明质酸大分子治疗椎间盘的方法。 还提供了一种基于用交联透明质酸大分子和间充质干细胞治疗来解决椎间盘髓核的细胞损失的再生治疗方法。
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公开(公告)号：US08241336B2
公开(公告)日：2012-08-14
申请号：US12248978
申请日：2008-10-10
CPC分类号： A61B17/688 , A61B17/1695 , A61F2/2846 , A61F2002/30032 , A61F2013/00357 , A61F2250/003
摘要： Craniotomy closure systems comprising surgical fasteners and a protective covering over the dura are described for use in reattaching a skull flap removed from the skull of a patient during brain surgery. Methods of using the same are also described. Surgical strips optionally used in combination with the craniotomy closure systems are shaped to follow the perimeter contour of the skull flap. The craniotomy closure systems are designed to encourage bone growth and healing of the skull flap and they can be used to deliver medication and bone growth enhancement materials to the surgical site.
摘要翻译： 描述了包括手术紧固件和在硬脑膜上的保护性覆盖物的开颅闭合系统，用于重新附着在脑手术期间从患者的颅骨移除的颅骨瓣。 还描述了使用它们的方法。 任选地与开颅闭合系统组合使用的手术条被成形为跟随颅骨瓣的周边轮廓。 开颅闭合系统旨在促进颅骨瓣的骨生长和愈合，并且它们可用于将药物和骨生长增强材料递送至手术部位。
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4.发明申请公开(公告)号：US20090252700A1
公开(公告)日：2009-10-08
申请号：US12380469
申请日：2009-02-27
IPC分类号： A61K31/775 , C08G63/91 , C08G65/48 , C08B37/00 , A61P19/00
CPC分类号： A61K31/775 , A61L27/20 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/38 , C08B37/0069 , C08B37/0072 , C08L5/08 , C08L2205/02 , C12P19/04 , C08L2666/26
摘要： A synthetic nucleus pulposus is provided that is useful in treatment of degenerative disc disease, augmentation of a degenerate disc, and alleviation of back pain. In an embodiment the synthetic nucleus pulposus comprises hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages. The synthetic nucleus pulposus restores or improves the water-retention capability of the disc. A method of treating an intervertebral disc with the cross-linked hyaluronan macromolecules is also provided. A method of regenerative therapy to address loss of cells of nucleus pulposus of an intervertebral disc based on treatment with the cross-linked hyaluronan macromolecules and mesenchymal stem cells is also provided.
摘要翻译： 提供了一种合成髓核，可用于治疗退行性椎间盘疾病，增加退行性椎间盘，减轻背部疼痛。 在一个实施方案中，合成髓核包含已经通过二羟基苯基键交联的透明质酸大分子。 合成髓核恢复或提高椎间盘的保水能力。 还提供了用交联的透明质酸大分子治疗椎间盘的方法。 还提供了一种基于用交联透明质酸大分子和间充质干细胞治疗来解决椎间盘髓核的细胞损失的再生治疗方法。
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公开(公告)号：US08088084B2
公开(公告)日：2012-01-03
申请号：US12043471
申请日：2008-03-06
申请人： Peter A. Zahos
发明人： Peter A. Zahos
CPC分类号： A61H23/0245 , A61B2017/00084 , A61B2017/00119 , A61B2017/00261 , A61B2090/065 , A61H2205/081 , A61N7/02
摘要： A method of repairing an intervertebral disc of a patient's body includes identifying a target area of the intervertebral disc. An ultrasound generator is placed proximate the target area and outside the patient's body. An area temperature at the target area is monitored. Ultrasonic energy is generated with the ultrasound generator within a predetermined energy range. The ultrasonic energy is adjusted in response to the area temperature exceeding a predetermined temperature range. An apparatus for repairing an intervertebral disc of a patient's body is also provided.
摘要翻译： 修复患者身体的椎间盘的方法包括识别椎间盘的目标区域。 将超声波发生器放置在目标区域附近和患者身体外部。 监视目标区域的面积温度。 超声发生器产生超声能量在预定的能量范围内。 响应于区域温度超过预定温度范围来调节超声波能量。 还提供了一种用于修复患者身体的椎间盘的装置。
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公开(公告)号：US20100094428A1
公开(公告)日：2010-04-15
申请号：US12248978
申请日：2008-10-10
CPC分类号： A61B17/688 , A61B17/1695 , A61F2/2846 , A61F2002/30032 , A61F2013/00357 , A61F2250/003
摘要： Craniotomy closure systems comprising surgical fasteners and a protective covering over the dura are described for use in reattaching a skull flap removed from the skull of a patient during brain surgery. Methods of using the same are also described. Surgical strips optionally used in combination with the craniotomy closure systems are shaped to follow the perimeter contour of the skull flap. The craniotomy closure systems are designed to encourage bone growth and healing of the skull flap and they can be used to deliver medication and bone growth enhancement materials to the surgical site.
摘要翻译： 描述了包括手术紧固件和在硬脑膜上的保护性覆盖物的开颅闭合系统，用于重新附着在脑手术期间从患者的颅骨移除的颅骨瓣。 还描述了使用它们的方法。 任选地与开颅闭合系统组合使用的手术条被成形为跟随颅骨瓣的周边轮廓。 开颅闭合系统旨在促进颅骨瓣的骨生长和愈合，并且它们可用于将药物和骨生长增强材料递送至手术部位。
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7.发明申请Method of treating a subject suffering from degenerative disc disease using a matrix metalloprotease inhibitor 有权使用基质金属蛋白酶抑制剂治疗患有退行性椎间盘疾病的受试者的方法公开(公告)号：US20070190149A1
公开(公告)日：2007-08-16
申请号：US11707315
申请日：2007-02-16
申请人： Peter A. Zahos
发明人： Peter A. Zahos
IPC分类号： A61K9/14
CPC分类号： A61K31/155 , A61K31/198 , A61K38/4886
摘要： The present invention provides a method for treating a vertebrate subject suffering from a degenerative disc disease by administering an inhibitor of a matrix metalloprotease (MMP) to the subject in an amount effective to treat the subject.
摘要翻译： 本发明提供一种通过以有效治疗受试者的量向对象施用基质金属蛋白酶（MMP）的抑制剂来治疗患有退行性椎间盘疾病的脊椎动物受试者的方法。
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8.发明授权Method of treating a subject suffering from degenerative disc disease using a matrix metalloprotease inhibitor 有权使用基质金属蛋白酶抑制剂治疗患有退行性椎间盘疾病的受试者的方法公开(公告)号：US08828977B2
公开(公告)日：2014-09-09
申请号：US11707315
申请日：2007-02-16
申请人： Peter A. Zahos
发明人： Peter A. Zahos
IPC分类号： A61K31/65 , A61K31/164
CPC分类号： A61K31/155 , A61K31/198 , A61K38/4886
摘要： The present invention provides a method for treating a vertebrate subject suffering from a degenerative disc disease by administering an inhibitor of a matrix metalloprotease (MMP) to the subject in an amount effective to treat the subject.
摘要翻译： 本发明提供一种通过以有效治疗受试者的量向对象施用基质金属蛋白酶（MMP）的抑制剂来治疗患有退行性椎间盘疾病的脊椎动物受试者的方法。
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