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    Polymeric proathocyanidin composition and application thereof
    1.
    发明申请
    Polymeric proathocyanidin composition and application thereof 有权

    公开(公告)号：US20220323484A1

    公开(公告)日：2022-10-13

    申请号：US17707818

    申请日：2022-03-29

    申请人： BELX BIO-PHARMACEUTICAL (TAIWAN) CORPORATION

    发明人： SHAU-FENG CHANG ,  I-HSIN CHUNG

    IPC分类号： A61K31/775 ,  A61K31/352 ,  A61P39/06 ,  A61P21/00

    摘要： The present invention relates to a pharmaceutical composition, which is characterized in that the composition comprises an effective amount of proanthocyanidin, the monomer units of the proanthocyanidin have the chemical formula of formula (I), and a pharmaceutically acceptable carrier or salt; wherein the proanthocyanidin is a polymeric proathocyanidin with a degree of polymerization ranging from 50-65. It has good antioxidant stress and can be used to treat or prevent brain diseases and aging-related diseases caused by excessive production of ROS, or to prevent and treat aging. It can also be used for the treatment and prevention of liver disease, tumor, sarcopenia and other diseases.

    Process for preparing synthetic soil-extract materials and medicaments based thereon
    5.
    发明授权
    Process for preparing synthetic soil-extract materials and medicaments based thereon 失效
    基于此制备合成土壤提取物材料和药物的方法

    公开(公告)号：US5945446A

    公开(公告)日：1999-08-31

    申请号：US798329

    申请日：1997-02-10

    申请人： Richard J. Laub

    发明人： Richard J. Laub

    IPC分类号： A61K9/02 ,  A01N65/00 ,  A61K9/08 ,  A61K9/12 ,  A61K9/20 ,  A61K9/72 ,  A61K31/765 ,  A61K31/775 ,  A61K35/14 ,  A61K35/16 ,  A61K36/00 ,  A61K38/00 ,  A61P3/04 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P43/00 ,  C08G61/00 ,  A61K31/35 ,  A61K35/78

    CPC分类号： A61K31/775 ,  A61K35/14 ,  A61K38/37 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10

    摘要： Phenolic polymers are prepared by dissolving one or more organic phenols along with sodium periodate in aqueous base at pH 8-11, and allowing the mixtures to stand between 35 and 80.degree. C. for a period of 30 minutes to 100 hours. One or more inorganic compounds or salts is added and the solution is allowed to stand at room temperature between 2 and 48 hours. Salt molecules as well as starting compounds and other low molecular-weight materials below about 500 to about 10,000 daltons are removed from the product solutions. Purified phenolic polymers are prepared in concentrated aqueous solution or in dried powder form in a final step if necessary. The resultant phenolic polymers exhibit physicochemical properties strongly resembling those of typical commercially-available natural soil extracts. The materials are active anti-viral and anti-microbial agents, and are effective in anti-viral amounts in blood product compositions, in methods for reducing or eliminating virus in blood products and in anti-viral and anti-microbial compositions for treating or preventing human or animal viral or microbial diseases.

    摘要翻译： 通过在pH 8-11下将一种或多种有机酚与高碘酸钠一起溶解在碱性水溶液中制备酚醛聚合物，并使混合物在35-80℃之间放置30分钟至100小时。 加入一种或多种无机化合物或盐，并将溶液在室温下放置2至48小时。 从产品溶液中除去盐分子以及起始化合物和低于约500至约10,000道尔顿的其它低分子量材料。 如果需要，在最终步骤中，将浓缩的水溶液或干燥粉末形式的纯化酚醛聚合物制备。 所得酚类聚合物显示出与典型的商业可得的天然土壤提取物类似的物理化学性质。 这些材料是活性抗病毒和抗微生物剂，并且在血液制品组合物中的抗病毒量，减少或消除血液制品中的病毒的方法和用于治疗或预防的抗病毒和抗微生物组合物中有效 人或动物病毒或微生物疾病。

    Cesium-specific phenolic ion exchange resin
    7.
    发明授权
    Cesium-specific phenolic ion exchange resin 失效
    铯特异性酚类离子交换树脂

    公开(公告)号：US5441991A

    公开(公告)日：1995-08-15

    申请号：US963965

    申请日：1992-10-21

    申请人： Jane P. Bibler ,  Richard M. Wallace

    发明人： Jane P. Bibler ,  Richard M. Wallace

    IPC分类号： B01J39/18 ,  A61K33/00 ,  A61K31/775

    CPC分类号： B01J39/185

    摘要： A phenolic, cesium-specific, cation exchange resin is prepared by neutralizing resorcinol with potassium hydroxide, condensing/polymerizing the resulting intermediate with formaldehyde, heat-curing the resulting polymer to effect cross-linking and grinding it to desired particle size for use. This resin will selectively and efficiently adsorb cesium ions in the presence of a high concentration of sodium ions with a low carbon to cesium ratio.

    摘要翻译： 通过用氢氧化钾中和间苯二酚来制备酚类，铯特异性阳离子交换树脂，将所得中间体与甲醛缩合/聚合，热固化所得聚合物以实现交联并将其研磨成所需的粒径以供使用。 这种树脂将在高浓度的钠离子存在下以低碳铯比选择性和有效地吸附铯离子。

    Polyamide-fixed biologically active protein
    8.
    发明授权
    Polyamide-fixed biologically active protein 失效
    聚酰胺固定生物活性蛋白

    公开(公告)号：US4182695A

    公开(公告)日：1980-01-08

    申请号：US878545

    申请日：1978-02-16

    申请人： Jurgen Horn ,  Winfried Albert ,  Hans-Georg Batz ,  Michael Nelbock-Hochstetter

    发明人： Jurgen Horn ,  Winfried Albert ,  Hans-Georg Batz ,  Michael Nelbock-Hochstetter

    IPC分类号： C08G69/00 ,  C08G69/48 ,  C08G69/50 ,  C08H1/00 ,  C12N11/08 ,  A61K31/765 ,  A61K31/775

    CPC分类号： C08G69/50 ,  C12N11/08 ,  Y10S530/816

    摘要： Biologically active protein compositions comprising protein or a protein substrate bound onto a polyamide of the general formula: ##STR1## in which R and R.sub.1, which may be the same or different, are polyamide residues bound onto the amido group,R.sub.2 is the residue of a compound which can be condensed with formaldehyde and which contains at least one further reactive group,R.sub.3 is the residue of a bi- or poly-functional protein reagent,n is 0 or 1, andP is a biologically active protein;these compositions are obtainable by the reaction of a polyamides with amounts, equimolar to one another, of formaldehyde and of a compound condensable with formaldehyde, in a solvent for polyamides, reacting the product thereby obtained with a bi- or poly-functional protein reagent and coupling the resulting reaction product with the biologically active protein or protein substrate.

    摘要翻译： 生物活性蛋白质组合物，其包含结合到以下通式的聚酰胺上的蛋白质或蛋白质底物：其中R和R 1可以相同或不同，是结合到酰胺基上的聚酰胺残基，R2是残基 可与甲醛缩合并含有至少一个其它反应性基团的化合物，R3是双功能或多功能蛋白质试剂的残基，n为0或1，P为生物活性蛋白; 这些组合物可以通过聚酰胺与等量的甲醛和与甲醛缩合的化合物的量与聚酰胺的溶剂反应，使由此获得的产物与双功能或多功能蛋白质试剂和 将所得反应产物与生物活性蛋白质或蛋白质底物偶联。