公开(公告)号：US4739034A

公开(公告)日：1988-04-19

申请号：US865020

申请日：1986-05-20

Applicant: Andrew A. Lindley

Inventor： Andrew A. Lindley

IPC: C08G69/00 ,  C07D223/18 ,  C08G69/26 ,  C08G69/40 ,  C08G69/42 ,  C08G69/46 ,  C08K7/02 ,  C08L77/00

CPC classification number: C08G69/26 ,  C07D223/18 ,  Y10T428/31721 ,  Y10T428/31725

Abstract: Polyamides containing in-chain aromatic groups, particularly diphenyl groups. Such polyamides may be prepared by reacting an alpha-omega-hydrocarbyl bis(biphenyl-2,2.sup.1 -dicarboxylmide) with a diamine and are useful as the matrix in fibre-reinforced composites.

Abstract translation: 含有链内芳族基团，特别是二苯基的聚酰胺。 这样的聚酰胺可以通过使α-ω-烃基双（联苯-2,21-二羧基）与二胺反应制备，并且可用作纤维增强复合材料中的基体。

公开(公告)号：US4434100A

公开(公告)日：1984-02-28

申请号：US206939

申请日：1980-11-14

Applicant: Heinz W. Gschwend

Inventor： Heinz W. Gschwend

IPC: C07D213/61 ,  C07D223/18 ,  C07D263/10 ,  C07D263/14 ,  C07D411/04 ,  A61K31/38

CPC classification number: C07D263/10 ,  C07D213/61 ,  C07D223/18 ,  C07D263/14

Abstract: 7-Aryl-5H-dibenz[c,e]azepines, e.g., those of the formula ##STR1## wheren: Ar'=phenyl, furyl, thienyl, pyridyl or phenyl subst. by alkyl, OH, alkoxy, halo or CF.sub.3 ;R'=halo or CF.sub.3N-oxides or salts thereof are anxiolytic, tranquilizing and anti-convulsant agents.

Abstract translation: 7-芳基-5H-二苯并[c，e]吖庚因，例如下式的那些：其中：Ar'=苯基，呋喃基，噻吩基，吡啶基或苯基。 烷基，OH，烷氧基，卤素或CF 3; R'=卤素或CF 3 N-氧化物或其盐是抗焦虑，镇定和抗惊厥剂。

公开(公告)号：US3821201A

公开(公告)日：1974-06-28

申请号：US17038471

申请日：1971-08-09

Applicant: MERCK & CO INC

Inventor： PESSOLANO A ,  WITZEL B ,  SHEN T ,  GRAHAM P ,  CLARK R

IPC: C07D223/18 ,  C07D41/08

CPC classification number: C07D223/18 ,  Y10S514/916

Abstract: Novel substituted-dibenzo(c,e)azepin-5-ones. The dibenzo(c, e)azepin-5-ones disclosed herein are potent anti-inflammatory, anti-pyretic and analgesic agents. Also included herein are pharmaceutical compositions containing said dibenzo(c,e)azepin-5one compounds as an active ingredient, and methods of treating inflammation, fever and pain in patients by administering said compounds. Further encompassed is 6,7-dihydro-5H-dibenzo(c, e)azepin-5-one possessing novel anti-inflammatory, anti-pyretic and analgesic activities.

公开(公告)号：US20180273483A1

公开(公告)日：2018-09-27

申请号：US15950065

申请日：2018-04-10

Applicant: Inception 3, Inc.

Inventor： Thomas Jon Seiders ,  Catherine Yuling Lee ,  Yiwei Li

IPC: C07D223/20 ,  A61K9/00 ,  A61K47/34 ,  A61K47/38 ,  A61K47/36 ,  A61K47/10 ,  A61K47/32 ,  A61K47/02 ,  A61P27/16

CPC classification number: C07D223/20 ,  A61K9/0046 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61P27/16 ,  C07B2200/13 ,  C07D223/18

Abstract: The present disclosure provides crystalline Compound I and crystalline Compound II, pharmaceutical compositions comprising one of said crystalline compounds suitable for intratympanic administration, and methods for treating otic disorders using the crystalline compounds and the pharmaceutical compositions.

公开(公告)号：US20130131337A1

公开(公告)日：2013-05-23

申请号：US13705506

申请日：2012-12-05

Applicant: NIPPON SODA CO., LTD.

Inventor： Keiji MARUOKA ,  Yasushi KUBOTA

IPC: B01J31/02

CPC classification number: B01J31/0271 ,  C07B53/00 ,  C07B2200/07 ,  C07C22/04 ,  C07C25/18 ,  C07C33/46 ,  C07C43/225 ,  C07D223/18 ,  C07D487/10

Abstract: An optically active bisbenzyl compound or a racemic bisbenzyl compound represented by formula (2) that has axial chirality. An optically active azepine derivative or a racemic azepine derivative represented by formula (3). Methods of producing an optically active quaternary ammonium salt compound represented by formula (8).

Abstract translation: 由式（2）表示的具有轴向手性的光学活性双苄基化合物或外消旋双苄基化合物。 光学活性吖庚因衍生物或由式（3）表示的外消旋吖庚因衍生物。 制备由式（8）表示的光学活性季铵盐化合物的方法。

公开(公告)号：US08258302B2

公开(公告)日：2012-09-04

申请号：US12162553

申请日：2007-01-31

Applicant: Hisatoshi Uehara

Inventor： Hisatoshi Uehara

IPC: C07D217/00 ,  C07D217/22 ,  A01N43/42 ,  A61K31/47

CPC classification number: C07C249/12 ,  C07C249/02 ,  C07D217/26 ,  C07D221/12 ,  C07D223/16 ,  C07D223/18 ,  C07C251/24 ,  C07C251/48

Abstract: It is an object of the present invention to provide 2-iminocarboxylic acid derivatives, and a practically suitable industrial method for producing benzazepinones in a short process under mild conditions. The present invention provides a method for producing a benzazepinone or a salt thereof, which comprises opening a ring of an isoquinoline derivative and subsequently converting the thus generated amine into a benzazepinone through lactamization reaction.

Abstract translation: 本发明的目的是提供2-亚氨基羧酸衍生物，以及在温和条件下在短时间内生产苯并氮杂酮的实际合适的工业方法。 本发明提供一种苯并氮杂酮或其盐的制备方法，其包括打开异喹啉衍生物的环，随后通过内酰胺化反应将由此产生的胺转化为苯并氮杂酮。

公开(公告)号：US08252952B2

公开(公告)日：2012-08-28

申请号：US13338601

申请日：2011-12-28

Applicant: Keiji Maruoka ,  Kenichiro Yamamoto ,  Yukifumi Nishimoto

Inventor： Keiji Maruoka ,  Kenichiro Yamamoto ,  Yukifumi Nishimoto

IPC: C07C229/06

CPC classification number: C07B53/00 ,  B01J31/0239 ,  B01J2231/46 ,  B01J2531/0266 ,  B01J2531/985 ,  C07B2200/07 ,  C07C43/225 ,  C07C249/02 ,  C07D223/18 ,  C07D487/04 ,  C07C251/24

Abstract: The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an α-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt having axial asymmetry of the present invention is a chiral phase-transfer catalyst that has a simple structure and that can be produced in a smaller number of process steps. The compound of the present invention is very useful as a phase-transfer catalyst in the synthesis of an α-alkyl-α-amino acid and a derivative thereof as well as an α,α-dialkyl-α-amino acid and a derivative thereof. Therefore, the compound of the present invention can be used in the development of novel foods and pharmaceuticals.

Abstract translation: 本发明公开了具有轴向不对称性的光学活性季铵盐和使用其制备α-氨基酸及其衍生物的方法。 具有本发明的轴向不对称性的光学活性季铵盐是手性相转移催化剂，其结构简单，可以以较少数量的工艺步骤生产。 本发明的化合物在α-烷基-α-氨基酸及其衍生物以及α，α-二烷基-α-氨基酸及其衍生物的合成中作为相转移催化剂是非常有用的 。 因此，本发明的化合物可用于开发新型食品和药物。

公开(公告)号：US08110680B2

公开(公告)日：2012-02-07

申请号：US12443588

申请日：2007-09-13

Applicant: Keiji Maruoka ,  Kenichiro Yamamoto ,  Yukifumi Nishimoto

Inventor： Keiji Maruoka ,  Kenichiro Yamamoto ,  Yukifumi Nishimoto

IPC: C07D223/18

CPC classification number: C07B53/00 ,  B01J31/0239 ,  B01J2231/46 ,  B01J2531/0266 ,  B01J2531/985 ,  C07B2200/07 ,  C07C43/225 ,  C07C249/02 ,  C07D223/18 ,  C07D487/04 ,  C07C251/24

Abstract: The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an α-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt having axial asymmetry of the present invention is a chiral phase-transfer catalyst that has a simple structure and that can be produced in a smaller number of process steps. The compound of the present invention is very useful as a phase-transfer catalyst in the synthesis of an α-alkyl-α-amino acid and a derivative thereof as well as an α,α-dialkyl-α-amino acid and a derivative thereof. Therefore, the compound of the present invention can be used in the development of novel foods and pharmaceuticals.

公开(公告)号：US20110207937A1

公开(公告)日：2011-08-25

申请号：US13051052

申请日：2011-03-18

Applicant: Xiaodong LI ,  Andrew Patron ,  Catherine Tachdjian ,  Hong Xu ,  Qing Li ,  Alexey Pronin ,  Guy Servant ,  Lan Zhang ,  Thomas Brady ,  Vincent Darmohusodo ,  Melissa Arellano ,  Victor Selchau ,  Brett Weylan Ching ,  Donald S. Karanewsky ,  Paul Brust ,  Jing Ling ,  Wen Zhao ,  Chad Priest

Inventor： Xiaodong LI ,  Andrew Patron ,  Catherine Tachdjian ,  Hong Xu ,  Qing Li ,  Alexey Pronin ,  Guy Servant ,  Lan Zhang ,  Thomas Brady ,  Vincent Darmohusodo ,  Melissa Arellano ,  Victor Selchau ,  Brett Weylan Ching ,  Donald S. Karanewsky ,  Paul Brust ,  Jing Ling ,  Wen Zhao ,  Chad Priest

IPC: C07D413/14 ,  C07D413/06

CPC classification number: C07C311/17 ,  A23L27/86 ,  A61K8/46 ,  A61K8/466 ,  A61K8/4933 ,  A61K8/494 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/4986 ,  A61K31/135 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/60 ,  A61K31/704 ,  A61K45/06 ,  A61Q11/00 ,  C07C233/73 ,  C07C311/04 ,  C07C311/13 ,  C07C311/16 ,  C07C311/18 ,  C07C311/19 ,  C07C311/20 ,  C07C311/21 ,  C07C311/29 ,  C07C311/46 ,  C07C323/49 ,  C07C335/16 ,  C07C335/18 ,  C07D213/42 ,  C07D213/71 ,  C07D217/08 ,  C07D223/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  C07D333/20 ,  C07D333/34 ,  A61K2300/00

Abstract: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

Abstract translation: 本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。 此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。 此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

公开(公告)号：US07759388B2

公开(公告)日：2010-07-20

申请号：US12253060

申请日：2008-10-16

Applicant: Nobuyasu Suzuki ,  Toshihiko Yoshimura ,  Hiroyuki Izawa ,  Kazuyuki Sagi ,  Shingo Makino ,  Eiji Nakanishi ,  Masahiro Murata ,  Takashi Tsuji

Inventor： Nobuyasu Suzuki ,  Toshihiko Yoshimura ,  Hiroyuki Izawa ,  Kazuyuki Sagi ,  Shingo Makino ,  Eiji Nakanishi ,  Masahiro Murata ,  Takashi Tsuji

IPC: A61K31/4035 ,  C07D209/48

CPC classification number: C07D207/452 ,  A61K31/395 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4412 ,  A61K31/45 ,  A61K31/472 ,  A61K31/48 ,  A61K31/4985 ,  A61K31/55 ,  C07D207/38 ,  C07D209/46 ,  C07D209/48 ,  C07D209/52 ,  C07D209/66 ,  C07D209/76 ,  C07D211/88 ,  C07D217/24 ,  C07D217/26 ,  C07D221/14 ,  C07D221/20 ,  C07D223/10 ,  C07D223/18 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the α 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which α 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

Abstract translation: 特定的苯丙氨酸衍生物或其药学上可接受的盐对α4整联蛋白具有拮抗作用，因此可用作治疗剂或其中α4整联蛋白依赖性粘附过程参与疾病如疾病的疾病的治疗剂或预防剂， 类风湿关节炎，炎性肠病，系统性红斑狼疮，多发性硬化症，Sjögren综合征，哮喘，牛皮癣，过敏，糖尿病，心血管疾病，动脉硬化，再狭窄，肿瘤增生，肿瘤转移和移植排斥。