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    Optically active ammonium salt compound, production intermediate thereof, and production method thereof
    1.
    发明授权
    Optically active ammonium salt compound, production intermediate thereof, and production method thereof 有权
    光学活性铵盐化合物及其制备方法及其制备方法

    公开(公告)号：US08367820B2

    公开(公告)日：2013-02-05

    申请号：US11817585

    申请日：2006-03-03

    Applicant: Keiji Maruoka ,  Yasushi Kubota

    Inventor： Keiji Maruoka ,  Yasushi Kubota

    IPC: C07D223/18

    CPC classification number: B01J31/0271 ,  C07B53/00 ,  C07B2200/07 ,  C07C22/04 ,  C07C25/18 ,  C07C33/46 ,  C07C43/225 ,  C07D223/18 ,  C07D487/10

    Abstract: Disclosed is an optically active quaternary ammonium salt compound represented by the formula (1) below. Also disclosed are a production intermediate of such an optically active quaternary ammonium salt compound, and a method for producing such an optically active quaternary ammonium salt compound. (1) (In the formula, R1, R2, R21, R3 and R4 respectively represent an alkyl group, an aryl group or the like; R5 and R6 respectively represent an alkyl group, an alkoxy group or the like; and X− represents an anion.)

    Abstract translation: 公开了由下式（1）表示的光学活性季铵盐化合物。 还公开了这种光学活性季铵盐化合物的制备中间体，以及这种光学活性季铵盐化合物的制造方法。 （1）（式中，R 1，R 2，R 21，R 3，R 4分别表示烷基，芳基等，R 5，R 6分别表示烷基，烷氧基等，X表示 阴离子）

    OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY, AND METHOD FOR PRODUCING ALPHA-AMINO ACID AND DERIVATIVE THEREOF BY USING THE SAME
    2.
    发明申请
    OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY, AND METHOD FOR PRODUCING ALPHA-AMINO ACID AND DERIVATIVE THEREOF BY USING THE SAME 审中-公开
    具有轴向不对称性的光学活性季铵盐，以及通过使用它们生产α-氨基酸及其衍生物的方法

    公开(公告)号：US20120101310A1

    公开(公告)日：2012-04-26

    申请号：US13338313

    申请日：2011-12-28

    Applicant: Keiji MARUOKA ,  Kenichiro Yamamoto ,  Yukifumi Nishimoto

    Inventor： Keiji MARUOKA ,  Kenichiro Yamamoto ,  Yukifumi Nishimoto

    IPC: C07C43/225

    CPC classification number: C07B53/00 ,  B01J31/0239 ,  B01J2231/46 ,  B01J2531/0266 ,  B01J2531/985 ,  C07B2200/07 ,  C07C43/225 ,  C07C249/02 ,  C07D223/18 ,  C07D487/04 ,  C07C251/24

    Abstract: The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an α-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt having axial asymmetry of the present invention is a chiral phase-transfer catalyst that has a simple structure and that can be produced in a smaller number of process steps. The compound of the present invention is very useful as a phase-transfer catalyst in the synthesis of an α-alkyl-α-amino acid and a derivative thereof as well as an α,α-dialkyl-α-amino acid and a derivative thereof. Therefore, the compound of the present invention can be used in the development of novel foods and pharmaceuticals.

    Abstract translation: 本发明公开了具有轴向不对称性的光学活性季铵盐和使用其制备α-氨基酸及其衍生物的方法。 具有本发明的轴向不对称性的光学活性季铵盐是手性相转移催化剂，其结构简单，可以以较少数量的工艺步骤生产。 本发明的化合物在α-烷基-α-氨基酸及其衍生物以及α，α-二烷基-α-氨基酸及其衍生物的合成中作为相转移催化剂是非常有用的 。 因此，本发明的化合物可用于开发新型食品和药物。

    SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION
    4.
    发明申请
    SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION 审中-公开
    作为ABETA蛋白质生产的抑制剂的替代的LACTAMS

    公开(公告)号：US20100048541A1

    公开(公告)日：2010-02-25

    申请号：US12561420

    申请日：2009-09-17

    Applicant: Qi HAN ,  Hong Liu ,  Richard E. Olson ,  Michael G. Yang

    Inventor： Qi HAN ,  Hong Liu ,  Richard E. Olson ,  Michael G. Yang

    IPC: A61K31/5513 ,  C07D243/24 ,  C07D401/04

    CPC classification number: C07D223/12 ,  C07D223/18 ,  C07D243/12 ,  C07D243/24 ,  C07D401/04

    Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

    Abstract translation: 本发明涉及式（I）的新型内酰胺：具有药物和生物影响性质，其药物组合物和使用方法。 这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ的生成，从而起到防止淀粉样蛋白的神经沉积的形成的作用。 更具体地说，本发明涉及与阿尔茨海默病和唐氏综合征等淀粉样蛋白生成相关的神经障碍的治疗。

    Photo radical generator, photo sensitive resin composition and article
    8.
    发明授权
    Photo radical generator, photo sensitive resin composition and article 有权
    光自由基发生器，感光树脂组合物及制品

    公开(公告)号：US07528205B2

    公开(公告)日：2009-05-05

    申请号：US10945697

    申请日：2004-09-21

    Applicant: Katsuya Sakayori

    Inventor： Katsuya Sakayori

    IPC: C08F2/48 ,  C08F2/46

    CPC classification number: C07D223/18 ,  C08F2/50 ,  C08F10/00 ,  C08F4/04

    Abstract: A photoradical generator which produces no low-molecular decomposition material but a radical during a photoradical generating process, does not generate a radical during a heating process, exists in a chemically stable state in a resulting product of a radical reaction such as a cured coating layer or the like, has high heat resistance, stability and preserving ability, and is excellent in compatibility or solubility is provided. The photoradical generator is comprised of a compound (a) having a seven-membered ring imide structure-containing group represented by the following formula (1), wherein, R1 to R8 respectively represent a hydrogen atom or a substituent and may be a cyclic structure in which they are bonded to each other.

    Abstract translation: 在光自由基产生过程中不产生低分子分解物质而不产生自由基的光自发生成器在加热过程中不产生自由基，在所得到的自由基反应产物如固化涂层中以化学稳定的状态存在 具有高的耐热性，稳定性和保存能力，并且具有优异的相容性或溶解性。 光自由基发生器由具有由下式（1）表示的含有7元环酰亚胺结构的基团的化合物（a）组成，其中，R 1〜R 8分别表示氢原子或取代基，可以是环状结构 其中它们彼此结合。

    LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
    9.
    发明申请
    LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION 审中-公开
    作为Abeta蛋白生产抑制剂的循环成分取代的LACTAMS

    公开(公告)号：US20090062256A1

    公开(公告)日：2009-03-05

    申请号：US12257809

    申请日：2008-10-24

    Applicant: Richard E. Olson

    Inventor： Richard E. Olson

    IPC: A61K31/55 ,  C07D243/24 ,  C07D487/04 ,  A61P25/28 ,  C07D487/14 ,  A61K31/5513

    CPC classification number: C07D223/12 ,  C07D223/16 ,  C07D223/18 ,  C07D243/14 ,  C07D243/24 ,  C07D243/26

    Abstract: This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

    Abstract translation: 本发明涉及具有式（I）的新型内酰胺：其药物组合物及其使用方法。 这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ肽的产生，从而起到防止淀粉样蛋白质神经沉积的形成的作用。 更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，例如阿尔茨海默病和唐氏综合征。

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