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公开(公告)号：US09827332B2
公开(公告)日：2017-11-28
申请号：US14940512
申请日：2015-11-13
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Jeff Lynn Ellsworth , Kenechi Ejebe , Justin Guild , Matthias John , Paul Hatala , Atanu Roy , Jason P. Schrum , Susan Whoriskey , Kristy M. Wood
IPC分类号： C12N15/85 , A61K47/48 , A61K48/00 , A61K31/7115 , A61K9/127 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , C07K14/47 , A61K38/17 , A61K38/45 , C07K14/005 , C07K14/435 , C07K14/485 , C07K14/505 , C07K14/62 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/88 , C12N9/00 , C12N15/11 , C12N15/52 , C12N15/87 , C12P13/04 , C12P21/00 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , C07K14/525 , C07K14/56 , A61K9/14 , A61K31/7088 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US09827328B2
公开(公告)日：2017-11-28
申请号：US15055940
申请日：2016-02-29
发明人： Hung T. Khong
IPC分类号： A61K38/38 , A61K31/337 , A61P35/00 , A61K47/48 , A61K38/19 , A61K45/06 , A61K31/436 , A61K31/675 , A61K31/704
CPC分类号： A61K47/643 , A61K31/337 , A61K31/436 , A61K31/675 , A61K31/704 , A61K38/193 , A61K45/06 , A61K47/6929 , A61K2300/00
摘要： The present invention relates to methods and compositions for the treatment of cancer. Some embodiments include methods of treating cancer comprising administering a chemotherapeutic agent associated with albumin, administering a second chemotherapeutic agent; and administering a third chemotherapeutic agent.
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53.发明授权公开(公告)号：US09814760B2
公开(公告)日：2017-11-14
申请号：US14878400
申请日：2015-10-08
申请人： ModernaTX, Inc.
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： C07H21/02 , C12N15/85 , A61K38/17 , C07K14/47 , C07K14/62 , A61K48/00 , A61K31/7115 , C12N9/88 , A61K9/127 , C12N15/11 , C07K14/705 , C07K14/505 , C07K14/535 , C12N9/64 , C12N9/10 , C12N9/00 , C12N9/42 , C12N15/87 , C12P13/04 , A61K38/45 , C07K14/005 , C12N9/16 , C12N9/24 , C12N15/52 , C07K14/435 , C12P21/00 , C07K14/485 , C07K14/475 , C07K14/495 , C07K14/525 , C07K14/54 , C07K14/56 , C07K14/61 , C07K14/745 , C07K16/28 , C07K16/40 , C12N9/02 , C12N9/12 , C12N9/68 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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54.发明授权公开(公告)号：US09801863B2
公开(公告)日：2017-10-31
申请号：US15347587
申请日：2016-11-09
发明人： Sanford Markowitz , Amar Desai , Stanton Gerson , Joseph Ready
IPC分类号： A61K31/4365 , A61K38/19 , A61K31/495
CPC分类号： A61K31/4365 , A61K31/495 , A61K38/193
摘要： A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
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公开(公告)号：US09750803B2
公开(公告)日：2017-09-05
申请号：US15230736
申请日：2016-08-08
发明人： Darrell J. Irvine , Jaehyun Moon
IPC分类号： A61K39/385 , A61K9/127 , A61K39/015 , A61K39/39 , A61K39/21 , A61K47/48 , C07K14/005 , C12N15/88 , A61K39/12 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/45 , A61K39/395 , A61K39/00
CPC分类号： A61K39/385 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/217 , A61K38/45 , A61K39/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/39 , A61K39/39533 , A61K47/6811 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6018 , C07K14/005 , C12N15/88 , C12N2740/15034 , C12N2740/16234 , C12Y207/10001 , Y02A50/412
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
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56.发明授权公开(公告)号：US09724368B2
公开(公告)日：2017-08-08
申请号：US14102295
申请日：2013-12-10
发明人： Misako Nakashima , Koichiro Iohara
CPC分类号： A61K35/28 , A61C5/50 , A61K35/32 , A61K38/193 , A61L27/3633 , A61L27/3834 , A61L27/3865 , A61L2430/12 , C12N5/0664 , A61K2300/00
摘要： Disclosed is a root canal filler for non-extracted tooth which causes no internal resorption or external resorption in a tooth with complete root formation, shows no odontoclast, and contributes to the regeneration of a dental tissue in which odontoblasts are smoothly aligned on the dentin wall. After pulpectomy or enlargement/cleaning of an infected root canal, a root canal filler for non-extracted tooth, which comprises tooth pulp stem cells and an extracellular matrix, is inserted into the apical side of the root canal of the non-extracted tooth. The tooth pulp stem cells may be, for example, dental pulp CXCR4-positive cells. It is preferred to attach, to the crown side of the root canal, migration factor(s) including at least one factor selected from among a cell migration factor, a cell proliferation factor, a neurotrophic factor and an angiogenic factor.
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57.发明申请公开(公告)号：US20170216265A1
公开(公告)日：2017-08-03
申请号：US15347587
申请日：2016-11-09
发明人： Sanford Markowitz , Amar Desai , Stanton Gerson , Joseph Ready
IPC分类号： A61K31/4365 , A61K31/495 , A61K38/19
CPC分类号： A61K31/4365 , A61K31/495 , A61K38/193
摘要： A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
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公开(公告)号：US20170204390A1
公开(公告)日：2017-07-20
申请号：US15407589
申请日：2017-01-17
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
IPC分类号： C12N9/52 , A61K39/395 , A61K38/27 , A61K38/30 , A61K38/17 , A61K38/19 , C07K14/51 , C07K14/50 , C07K16/18 , C07K14/61 , C07K14/475 , C07K14/495 , C07K14/71 , C07K14/535 , C07K14/49 , C07K14/485 , A61K38/18
CPC分类号： C12N9/52 , A61K8/4913 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/99 , A61K38/00 , A61K38/179 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/193 , A61K38/27 , A61K38/29 , A61K38/30 , A61K39/3955 , A61K39/44 , A61K47/64 , A61K2039/505 , A61K2039/6031 , A61K2800/57 , A61Q7/00 , A61Q7/02 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12Y304/24003
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号：US20170198061A1
公开(公告)日：2017-07-13
申请号：US15320679
申请日：2015-06-20
申请人： Stephen D. Gillies
发明人： Stephen D. Gillies
IPC分类号： C07K16/42 , A61K39/395 , A61K38/19 , C07K14/535
CPC分类号： C07K16/4216 , A61K38/193 , A61K39/12 , A61K39/39566 , A61K2039/505 , A61K2039/6056 , C07K14/535 , C07K16/1018 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C12N2760/16134
摘要： The disclosure relates to anti-idiotypic antibodies and related influenza virus vaccines.
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公开(公告)号：US09675641B2
公开(公告)日：2017-06-13
申请号：US14638676
申请日：2015-03-04
发明人： Louis M. Pelus , Jonathan Hoggatt , Pratibha Singh
IPC分类号： C12N5/00 , C12N15/00 , C12N15/63 , A61K48/00 , A61K35/14 , A61K31/00 , C12N5/0789 , A61K31/395 , A61K31/405 , A61K31/5415 , A61K35/28 , A61K35/50 , A61K35/51 , A61K38/19 , C12N9/02 , A61K31/4035 , A61K31/4196 , C12N5/16 , C12N15/86 , A61K35/12
CPC分类号： A61K35/14 , A61K31/00 , A61K31/395 , A61K31/4035 , A61K31/405 , A61K31/4196 , A61K31/5415 , A61K35/28 , A61K35/50 , A61K35/51 , A61K38/193 , A61K2035/124 , C12N5/0647 , C12N5/16 , C12N9/0083 , C12N15/63 , C12N15/86 , C12N2501/02 , C12Y114/99001
摘要： This disclosure is directed to the methods of enhancing hematopoietic stem cells (HSPC) and progenitor cell (HSPC) engraftment procedure. Treatment in vivo of a HSPC donor with compounds that reduce PGE2 biosynthesis or PGE2 receptor antagonists alone, or in combination with other hematopoietic mobilization agents such as AMD3100 and G-CSF, increases the circulation of available HSPCs. Compounds that reduce the cellular synthesis of PGE2 include non-steroidal anti-inflammatory compounds such as indomethacin. Treatment ex vivo of HSPC with an effective amount of PGE2 or at least one of its derivatives such as 16,16-dimethyl prostaglandin E2 (dmPGE2), promotes HSPC engraftment. Similar methods may also be used to increase viral-mediated gene transduction efficacy into HSPC.
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