公开(公告)号：US10654913B2

公开(公告)日：2020-05-19

申请号：US16032691

申请日：2018-07-11

Applicant: Janssen Biotech, Inc.

Inventor： Steven Jacobs ,  Karyn O'Neil

IPC: C40B40/10 ,  C07K14/78 ,  C40B50/06 ,  C40B40/08

Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

公开(公告)号：US10280200B2

公开(公告)日：2019-05-07

申请号：US15710385

申请日：2017-09-20

Applicant: Janssen Biotech, Inc.

Inventor： Steven Jacobs

IPC: C07K14/00 ,  C07K14/31 ,  C07K14/47 ,  C07K14/315

Abstract: Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in controlling the half-life of therapeutic molecules for patients.

公开(公告)号：US20180162929A1

公开(公告)日：2018-06-14

申请号：US15840303

申请日：2017-12-13

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  C07K14/705 ,  C12N15/85 ,  A61P35/00

Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US20180162927A1

公开(公告)日：2018-06-14

申请号：US15839915

申请日：2017-12-13

Applicant: Janssen Biotech, Inc.

Inventor： Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  G01N33/569 ,  G01N33/68

Abstract: Fibronectin type III domains (FN3) that specifically bind to CD8A, related polynucleotides capable of encoding CD8A-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, and detectably labeled FN3 domains are useful in therapeutic and diagnostic applications.

公开(公告)号：US20180009854A1

公开(公告)日：2018-01-11

申请号：US15710385

申请日：2017-09-20

Applicant: Janssen Biotech, Inc.

Inventor： Steven Jacobs

IPC: C07K14/315 ,  C07K14/31 ,  C07K14/00 ,  C07K14/47

CPC classification number: C07K14/315 ,  C07K14/001 ,  C07K14/31 ,  C07K14/47 ,  C07K2319/01 ,  C07K2319/31

Abstract: Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in controlling the half-life of therapeutic molecules for patients.

公开(公告)号：US20170348397A1

公开(公告)日：2017-12-07

申请号：US15611296

申请日：2017-06-01

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs ,  Karyn O'Neil ,  Thomas Rutkoski

IPC: A61K38/39 ,  C07K16/40 ,  C07K14/78 ,  C07K16/18

CPC classification number: A61K38/39 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/78 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/94 ,  C07K2318/20 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/70

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.

公开(公告)号：US20160041182A1

公开(公告)日：2016-02-11

申请号：US14822335

申请日：2015-08-10

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs

IPC: G01N33/68

CPC classification number: G01N33/6845 ,  C12N15/1044 ,  C40B30/04 ,  C40B40/08 ,  C40B50/06 ,  G01N2333/78

Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US09234029B2

公开(公告)日：2016-01-12

申请号：US14033994

申请日：2013-09-23

Applicant: Janssen Biotech, Inc.

Inventor： Steven Jacobs

IPC: A61K49/00 ,  C07K14/00 ,  C40B50/00 ,  C40B40/08 ,  C40B40/02 ,  C40B30/04 ,  C07K14/78 ,  C12N15/10 ,  A61K38/00

CPC classification number: C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C07K16/18 ,  C07K2318/20 ,  Y02A50/473

Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US20140155325A1

公开(公告)日：2014-06-05

申请号：US14085340

申请日：2013-11-20

Applicant: Janssen Biotech, Inc.

Inventor： Anderson Mark ,  Ricardo Attar ,  Michael Diem ,  Linus Hyun ,  Steven Jacobs ,  Alastair King ,  Donna Klein ,  Sheri Moores ,  Karyn O'Neil ,  Kristen Picha

IPC: C07K14/78 ,  A61K45/06 ,  A61K38/39

CPC classification number: C07K14/78 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/70

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US20140018519A1

公开(公告)日：2014-01-16

申请号：US14033994

申请日：2013-09-23

Applicant: Janssen Biotech, Inc.

Inventor： Steven Jacobs

IPC: C07K14/78

CPC classification number: C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C07K16/18 ,  C07K2318/20 ,  Y02A50/473

Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用表现出增强的热和化学稳定性，同时呈现六个可修饰的环结构域，其可被工程化以形成能够结合靶标的结合配偶体，用于诊断和/或治疗组合物，方法和装置中的应用。