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公开(公告)号：US20210147510A1
公开(公告)日：2021-05-20
申请号：US16949078
申请日：2020-10-13
Applicant: Janssen Biotech, Inc.
Inventor： Rosa Cardoso , Michael Diem , Shalom Goldberg , Linus Hyun , Steven Jacobs , Donna Klein , Karyn O'Neil , Tracy Spinka-Doms
IPC: C07K14/78 , A61K51/08 , G01N33/574
Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US20200325210A1
公开(公告)日：2020-10-15
申请号：US16840479
申请日：2020-04-06
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Shalom Goldberg , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.
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公开(公告)号：US20140155325A1
公开(公告)日：2014-06-05
申请号：US14085340
申请日：2013-11-20
Applicant: Janssen Biotech, Inc.
Inventor： Anderson Mark , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
CPC classification number: C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US20210206825A1
公开(公告)日：2021-07-08
申请号：US17174524
申请日：2021-02-12
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC: C07K14/705 , C07K14/78 , C07K14/71 , C07K16/28 , C07K14/47
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US09725497B2
公开(公告)日：2017-08-08
申请号：US14086250
申请日：2013-11-21
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC: C07K19/00 , C07K14/78 , A61K45/06 , C07K16/28 , C07K14/705 , C07K14/71 , C07K14/47 , A61K38/00 , A61K39/00
CPC classification number: C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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Patent Agency Ranking
公开(公告)号：US09695228B2
公开(公告)日：2017-07-04
申请号：US14085340
申请日：2013-11-20
Applicant: Janssen Biotech, Inc.
Inventor： Anderson Mark , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC: C07K16/46 , A61K39/395 , C07K14/78 , A61K45/06 , C07K16/28 , C07K14/705 , C07K14/71 , C07K14/47 , A61K38/00 , A61K39/00
CPC classification number: C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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7.发明申请Prostate Specific Membrane Antigen (PSMA) Bispecific Binding Agents and Uses Thereof 审中-公开前列腺特异性膜抗原（PSMA）双特异性结合剂及其用途公开(公告)号：US20160347840A1
公开(公告)日：2016-12-01
申请号：US15148371
申请日：2016-05-06
Applicant: Janssen Biotech, Inc.
Inventor： Glenn Anderson , Rosa Cardoso , Michael Diem , Francois Gaudet , Shalom Goldberg , Benjamin Harman , Linus Hyun , Steven Jacobs , Donna Klein , Yingzhe Li , Jinquan Luo , Ronan McDaid , Jill Mooney , Jennifer Nemeth-Seay , Karyn O'Neil , Steven Pomerantz , Galla Chandra Rao , Tracy Spinka-Doms , Alexey Teplyakov , Leopoldo Luistro , Sheng-Jiun Wu
IPC: C07K16/28 , C07K14/78 , A61K45/06 , C07K16/30 , A61K39/395
CPC classification number: C07K16/2809 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K49/0045 , A61K49/0058 , A61K2039/505 , C07K14/78 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/70 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C12Y304/17021
Abstract: Provided herein are isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.
Abstract translation: 本文提供了分离的CD3×PSMA-双特异性抗原结合分子或其双特异性抗原结合片段，其中FN3结构域特异性结合人前列腺特异性膜抗原（PSMA）和第二抗原结合位点免疫特异性结合CD3。 还描述了能够编码所提供的融合蛋白的融合蛋白和相关多核苷酸，以及表达所提供的融合蛋白的细胞。 此外，描述了使用所提供的分离的CD3×PSMA-双特异性抗原结合分子或其双特异性抗原结合片段的方法。
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8.发明申请Prostate Specific Membrane Antigen Binding Fibronectin Type III Domains 审中-公开前列腺特异性膜抗原结合纤连蛋白III型结构域公开(公告)号：US20160326232A1
公开(公告)日：2016-11-10
申请号：US15148312
申请日：2016-05-06
Applicant: Janssen Biotech, Inc.
Inventor： Cardosa Rosa , Michael Diem , Shalom Goldberg , Linus Hyun , Steven Jacobs , Donna Klein , Karyn O'Neil , Tracy Spinka-Doms
IPC: C07K14/78 , G01N33/573 , A61K51/08
CPC classification number: C07K14/78 , A61K38/00 , A61K51/08 , G01N33/57434 , G01N2333/705
Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
Abstract translation: PSMA结合FN3结构域，它们的缀合物，编码分子的分离的核苷酸，载体，宿主细胞及其制备方法可用于治疗分子的产生以及疾病和病症的治疗和诊断。
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公开(公告)号：US12054534B2
公开(公告)日：2024-08-06
申请号：US16949078
申请日：2020-10-13
Applicant: Janssen Biotech, Inc.
Inventor： Rosa Cardoso , Michael Diem , Shalom Goldberg , Linus Hyun , Steven Jacobs , Donna Klein , Karyn O'Neil , Tracy Spinka-Doms
IPC: G01N33/574 , A61K51/08 , C07K14/78 , A61K38/00
CPC classification number: C07K14/78 , A61K51/08 , G01N33/57434 , A61K38/00 , G01N2333/705
Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US10954284B2
公开(公告)日：2021-03-23
申请号：US15637276
申请日：2017-06-29
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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