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公开(公告)号：US12291797B2
公开(公告)日：2025-05-06
申请号：US17932117
申请日：2022-09-14
Applicant: Janssen Biotech, Inc.
Inventor： Steven Jacobs , Karyn O'Neil
Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
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公开(公告)号：US20210147510A1
公开(公告)日：2021-05-20
申请号：US16949078
申请日：2020-10-13
Applicant: Janssen Biotech, Inc.
Inventor： Rosa Cardoso , Michael Diem , Shalom Goldberg , Linus Hyun , Steven Jacobs , Donna Klein , Karyn O'Neil , Tracy Spinka-Doms
IPC: C07K14/78 , A61K51/08 , G01N33/574
Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US20210040180A1
公开(公告)日：2021-02-11
申请号：US16820844
申请日：2020-03-17
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
IPC: C07K14/78 , A61P35/00 , C12N15/85 , C07K14/705 , G01N33/68 , G01N33/574 , G01N33/53
Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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公开(公告)号：US20210024612A1
公开(公告)日：2021-01-28
申请号：US16801787
申请日：2020-02-26
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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公开(公告)号：US10597438B2
公开(公告)日：2020-03-24
申请号：US15840281
申请日：2017-12-13
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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Patent Agency Ranking
公开(公告)号：US20160083436A1
公开(公告)日：2016-03-24
申请号：US14842218
申请日：2015-09-01
Applicant: Janssen Biotech, Inc.
Inventor： Steven Jacobs
IPC: C07K14/315
CPC classification number: C07K14/315 , C07K14/001 , C07K14/31 , C07K14/47 , C07K2319/01 , C07K2319/31
Abstract: Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in controlling the half-life of therapeutic molecules for patients.
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公开(公告)号：US20160039909A1
公开(公告)日：2016-02-11
申请号：US14921589
申请日：2015-10-23
Applicant: Janssen Biotech, Inc.
Inventor： Steven Jacobs , Karyn O'Neil
IPC: C07K14/78
Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
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公开(公告)号：US12054534B2
公开(公告)日：2024-08-06
申请号：US16949078
申请日：2020-10-13
Applicant: Janssen Biotech, Inc.
Inventor： Rosa Cardoso , Michael Diem , Shalom Goldberg , Linus Hyun , Steven Jacobs , Donna Klein , Karyn O'Neil , Tracy Spinka-Doms
IPC: G01N33/574 , A61K51/08 , C07K14/78 , A61K38/00
CPC classification number: C07K14/78 , A61K51/08 , G01N33/57434 , A61K38/00 , G01N2333/705
Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US11833190B2
公开(公告)日：2023-12-05
申请号：US17153229
申请日：2021-01-20
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Steven Jacobs , Karyn O'Neil , Thomas Rutkoski
CPC classification number: A61K38/39 , A61K47/549 , C07K14/78 , C07K16/18 , C07K16/40 , G01N33/68 , A61K2039/505 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70 , G01N2333/765 , G01N2333/78
Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.
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公开(公告)号：US20230071749A1
公开(公告)日：2023-03-09
申请号：US17932117
申请日：2022-09-14
Applicant: Janssen Biotech, Inc.
Inventor： Steven Jacobs , Karyn O'Neil
Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
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