公开(公告)号：US11932680B2

公开(公告)日：2024-03-19

申请号：US17689869

申请日：2022-03-08

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07H21/04 ,  A61K49/00 ,  A61K51/08 ,  C07K14/78 ,  C12N5/02 ,  C12N15/74 ,  C12N15/87 ,  C12P21/06 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569 ,  G01N33/574 ,  G01N33/68

CPC classification number: C07K14/78 ,  A61K49/0002 ,  A61K51/088 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569 ,  G01N33/56966 ,  G01N33/574 ,  G01N33/57492 ,  G01N33/68 ,  G01N33/6887 ,  G01N2333/70517 ,  G01N2333/78

Abstract: Fibronectin type III domains (FN3) that specifically bind to CD8A, related polynucleotides capable of encoding CD8A-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, and detectably labeled FN3 domains are useful in therapeutic and diagnostic applications.

公开(公告)号：US20180162928A1

公开(公告)日：2018-06-14

申请号：US15840281

申请日：2017-12-13

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  C07K14/705 ,  C12N15/85 ,  A61P35/00

Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US20220259289A1

公开(公告)日：2022-08-18

申请号：US17732420

申请日：2022-04-28

Applicant: JANSSEN BIOTECH, INC

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  A61P35/00 ,  C12N15/85 ,  C07K14/705 ,  G01N33/68 ,  G01N33/574 ,  G01N33/53

Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US20210032312A1

公开(公告)日：2021-02-04

申请号：US16821064

申请日：2020-03-17

Applicant: Janssen Biotech, Inc.

Inventor： Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  G01N33/569 ,  G01N33/68 ,  G01N33/566 ,  A61K51/08 ,  G01N33/53 ,  A61K49/00 ,  G01N33/574

Abstract: Fibronectin type III domains (FN3) that specifically bind to CD8A, related polynucleotides capable of encoding CD8A-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, and detectably labeled FN3 domains are useful in therapeutic and diagnostic applications.

公开(公告)号：US20210040180A1

公开(公告)日：2021-02-11

申请号：US16820844

申请日：2020-03-17

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  A61P35/00 ,  C12N15/85 ,  C07K14/705 ,  G01N33/68 ,  G01N33/574 ,  G01N33/53

Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US20210024612A1

公开(公告)日：2021-01-28

申请号：US16801787

申请日：2020-02-26

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  A61P35/00 ,  C12N15/85 ,  C07K14/705 ,  C07K16/28 ,  C07K14/71

Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US10597438B2

公开(公告)日：2020-03-24

申请号：US15840281

申请日：2017-12-13

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/705 ,  C07K14/71 ,  C07K14/78 ,  A61P35/00 ,  C12N15/85 ,  C07K16/28 ,  A61K38/17

Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US12258385B2

公开(公告)日：2025-03-25

申请号：US17732420

申请日：2022-04-28

Applicant: JANSSEN BIOTECH, INC

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  A61P35/00 ,  C07K14/705 ,  C12N15/85 ,  G01N33/53 ,  G01N33/566 ,  G01N33/574 ,  G01N33/68 ,  A61K38/39 ,  C07K14/71

Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US20240301033A1

公开(公告)日：2024-09-12

申请号：US18436312

申请日：2024-02-08

Applicant: Janssen Biotech, Inc.

Inventor： Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  A61K49/00 ,  A61K51/08 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569 ,  G01N33/574 ,  G01N33/68

CPC classification number: C07K14/78 ,  A61K49/0002 ,  A61K51/088 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569 ,  G01N33/56966 ,  G01N33/574 ,  G01N33/57492 ,  G01N33/68 ,  G01N33/6887 ,  G01N2333/70517 ,  G01N2333/78

Abstract: Fibronectin type III domains (FN3) that specifically bind to CD8A, related polynucleotides capable of encoding CD8A-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, and detectably labeled FN3 domains are useful in therapeutic and diagnostic applications.

公开(公告)号：US11447539B2

公开(公告)日：2022-09-20

申请号：US16801787

申请日：2020-02-26

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/705 ,  C07K14/71 ,  C07K14/78 ,  A61P35/00 ,  C12N15/85 ,  C07K16/28 ,  A61K38/17 ,  A61K38/39

Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.