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公开(公告)号：US10662235B2
公开(公告)日：2020-05-26
申请号：US15629090
申请日：2017-06-21
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Alastair King , Steven Jacobs , Shalom Goldberg , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.
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2.发明申请公开(公告)号：US20140155326A1
公开(公告)日：2014-06-05
申请号：US14086250
申请日：2013-11-21
Applicant: Janssen Biotech, Inc.
Inventor： Anderson Mark , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
CPC classification number: C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
Abstract translation: 单特异性和双特异性EGFR和/或c-Met FN3结构域分子，编码分子的分离的核苷酸，载体，宿主细胞及其制备方法可用于治疗分子的产生以及疾病和病症的治疗和诊断。
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公开(公告)号：US11466082B2
公开(公告)日：2022-10-11
申请号：US16418420
申请日：2019-05-21
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Francois Gaudet , Ronan McDaid , Priyanka Nair-Gupta
Abstract: Anti-CD33 antibodies and antigen-binding fragments thereof and anti-CD33/anti-CD3 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
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公开(公告)号：US20210147510A1
公开(公告)日：2021-05-20
申请号：US16949078
申请日：2020-10-13
Applicant: Janssen Biotech, Inc.
Inventor： Rosa Cardoso , Michael Diem , Shalom Goldberg , Linus Hyun , Steven Jacobs , Donna Klein , Karyn O'Neil , Tracy Spinka-Doms
IPC: C07K14/78 , A61K51/08 , G01N33/574
Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US20210040180A1
公开(公告)日：2021-02-11
申请号：US16820844
申请日：2020-03-17
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
IPC: C07K14/78 , A61P35/00 , C12N15/85 , C07K14/705 , G01N33/68 , G01N33/574 , G01N33/53
Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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Patent Agency Ranking
公开(公告)号：US20210024612A1
公开(公告)日：2021-01-28
申请号：US16801787
申请日：2020-02-26
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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公开(公告)号：US10597438B2
公开(公告)日：2020-03-24
申请号：US15840281
申请日：2017-12-13
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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公开(公告)号：US20190382481A1
公开(公告)日：2019-12-19
申请号：US16418420
申请日：2019-05-21
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Francois Gaudet , Ronan McDaid , Priyanka Nair-Gupta
Abstract: Anti-CD33 antibodies and antigen-binding fragments thereof and anti-CD33/anti-CD3 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
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公开(公告)号：US20220259289A1
公开(公告)日：2022-08-18
申请号：US17732420
申请日：2022-04-28
Applicant: JANSSEN BIOTECH, INC
Inventor： Michael Diem , Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
IPC: C07K14/78 , A61P35/00 , C12N15/85 , C07K14/705 , G01N33/68 , G01N33/574 , G01N33/53
Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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公开(公告)号：US20210206825A1
公开(公告)日：2021-07-08
申请号：US17174524
申请日：2021-02-12
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC: C07K14/705 , C07K14/78 , C07K14/71 , C07K16/28 , C07K14/47
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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