公开(公告)号：US20250019429A1

公开(公告)日：2025-01-16

申请号：US18892683

申请日：2024-09-23

Applicant: Janssen Biotech, Inc.

Inventor： Kristopher Barnthouse ,  Subinay Ganguly ,  Maarten Groeneveld ,  Manuel Lopez, JR. ,  Michael Nedved ,  Kevin D. Smith

IPC: C07K16/24

Abstract: Presented here are methods for producing a recombinant anti-TNF antibody having a heavy chain (HC) comprising SEQ ID NO:38 and a light chain (LC) comprising SEQ ID NO:37 and compositions comprising the recombinant anti-TNF antibody.

公开(公告)号：US20250011454A1

公开(公告)日：2025-01-09

申请号：US18703264

申请日：2022-10-19

Applicant: Janssen Biotech, Inc.

Inventor： Adam ZWOLAK ,  Jason HO ,  James TESTA, Jr. ,  Michael Riis HANSEN ,  Xiefan LIN-SCHMIDT ,  Ian WHITE ,  Sanjaya SINGH

IPC: C07K16/28 ,  C07K16/30

Abstract: Provided herein, in certain aspects, is a binding molecule comprising an antigen binding domain and an Fc region; wherein the antigen binding domain is monovalent and the Fc region comprises K248E and T437R mutations (RE mutations), wherein amino acid residue numbering is according to the EU numbering system; wherein the binding molecule has increased capability of hexamerization on a cell surface, and/or increased capability of engaging C1q.

公开(公告)号：US20240417693A1

公开(公告)日：2024-12-19

申请号：US18415550

申请日：2024-01-17

Applicant: Janssen Biotech, Inc.

Inventor： Sebastian Rieck ,  Alireza Rezania

IPC: C12N5/071 ,  A61K35/39 ,  C07K14/72 ,  C12Q1/6806

Abstract: The invention provides for methods of differentiating pancreatic endocrine cells into pancreatic beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A. These pancreatic beta cells may be obtained by step-wise differentiation of pluripotent stem cells. The pancreatic beta cells exhibit glucose-dependent mitochondrial respiration and glucose-stimulated insulin secretion similar to islet cells.

公开(公告)号：US20240409634A1

公开(公告)日：2024-12-12

申请号：US18691254

申请日：2022-09-12

Applicant: Janssen Biotech, Inc.

Inventor： Patrick John DOONAN ,  Sherry Lynn LA PORTE ,  Sanjaya SINGH ,  Paul Willem Henri lda PARREN ,  Sabrina Julia Louisa MERAT ,  Robertus Cornelis ROOVERS ,  Sara Mohamed A ELASHKAR ,  Ulrike PHILIPPAR

IPC: C07K16/28 ,  A61P35/02

Abstract: The invention relates to multispecific antibodies and pharmaceutical compositions comprising said antibodies, to processes for the preparation of said antibodies and to the use of said antibodies targeting CD33 and to their use in the treatment of diseases, e.g., cancer.

公开(公告)号：US20240409598A1

公开(公告)日：2024-12-12

申请号：US18579062

申请日：2022-07-14

Applicant: Janssen Biotech, Inc. ,  Protagonist Therapeutics, Inc.

Inventor： Stephanie A. Barros ,  Charles Hendrick ,  Santhosh Neelamkavil ,  Raymond J. Patch ,  Sandeep Somani ,  Chengzao Sun ,  Jing Zhang ,  Elisabetta Bianchi ,  Danila Branca ,  Roberto Costante ,  Raffaele Ingenito ,  Ashok Bhandari ,  Brian Frederick ,  James Daniel ,  Tran Trung Tran

IPC: C07K14/54 ,  A61K38/00

Abstract: The present invention relates to novel cyclic peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders. The inhibitor of an interleukin-23 receptor is cyclized by a disulfide bond between penicillamine, cysteine, homocysteine, or alpha methylcysteine residues at positions X4 and X9.

公开(公告)号：US12162951B2

公开(公告)日：2024-12-10

申请号：US17376830

申请日：2021-07-15

Applicant: Janssen Biotech, Inc.

Inventor： Zemeda Ainekulu ,  Qiang Chen ,  Ellen Chi ,  Wilson Edwards ,  Matt Husovsky ,  Ann Lacombe ,  Quynh Nguyen ,  Paul H. Kim ,  H. Mimi Zhou ,  John T. Lee

IPC: G01N33/53 ,  C07H21/04 ,  C07K1/22 ,  C07K16/42 ,  C12N5/02 ,  C12N15/00 ,  C12P21/06 ,  G01N33/68

Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a KL2B413 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include KL2B413.

公开(公告)号：US20240384002A1

公开(公告)日：2024-11-21

申请号：US18792966

申请日：2024-08-02

Applicant: Janssen Biotech, Inc.

Inventor： Vadim Dudkin ,  Shalom Goldberg ,  Michael J. McCauley ,  Kristen Wiley

IPC: C07K16/30 ,  A61K47/54 ,  A61K47/62 ,  A61K47/68 ,  C07K1/107

Abstract: Provided herein are methods for site-specific conjugation of glycan intact antibodies by a transglutaminase. According to particular embodiments, the reaction conditions are maintained or reduced to a low-ionic strength condition, which allows for efficient and fast conjugation without the need for antibody deglycosylation. Also described are pharmaceutical compositions and uses related to the conjugation method.

公开(公告)号：US20240360421A1

公开(公告)日：2024-10-31

申请号：US18630620

申请日：2024-04-09

Applicant: JANSSEN BIOTECH, INC.

Inventor： Iqbal S GREWAL ,  Rajkumar GANESAN ,  Sanjaya SINGH

IPC: C12N5/074 ,  A61K35/545 ,  C12N15/86

CPC classification number: C12N5/0696 ,  A61K35/545 ,  C12N15/86 ,  C12N2501/2315 ,  C12N2501/999 ,  C12N2502/1114

Abstract: Provided here in are methods of producing induced pluripotent stem cells (iPSCs) and isolated population of produced induced pluripotent stem cells (iPSCs). Also provided herein are methods of treating a subject in need thereof using the produced iPSCs or pharmaceutical compositions comprising the produced iPSCs.

公开(公告)号：US12129310B2

公开(公告)日：2024-10-29

申请号：US18122948

申请日：2023-03-17

Applicant: Janssen Biotech, Inc.

Inventor： Sanjaya Singh ,  Rajkumar Ganesan ,  Jun Chen ,  Iqbal S. Grewal

IPC: C07K16/42 ,  G01N33/68

CPC classification number: C07K16/42 ,  G01N33/6857 ,  C07K2317/14 ,  C07K2317/34

Abstract: Molecules, including antibodies and antigen-binding fragments thereof that specifically bind to a linker peptide, and methods of producing and using the described antibodies and antigen-binding fragments are presented herein. Also presented herein methods of generating antibodies that specifically bind to an immunorecessive epitope.

公开(公告)号：US20240327869A1

公开(公告)日：2024-10-03

申请号：US18744565

申请日：2024-06-14

Applicant: JANSSEN BIOTECH, INC.

Inventor： William Lloyd PERRY, III ,  Brian TOMKOWICZ

IPC: C12N15/86 ,  C12N7/00

CPC classification number: C12N15/86 ,  C12N7/00 ,  C12N2750/14121 ,  C12N2750/14151 ,  C12N2800/50 ,  C12N2830/36 ,  C12N2830/40 ,  C12N2830/42 ,  C12N2830/50

Abstract: Recombinant constructs, cells and means for improved production of Adeno-Associated Viruses (AAVs) are described. Also described are methods of using the constructs and cells to produce recombinant AAVs.