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公开(公告)号：US20240352073A1
公开(公告)日：2024-10-24
申请号：US18579033
申请日：2022-07-14
Applicant: Janssen Biotech, Inc. , Protagonist Therapeutics, Inc.
Inventor： Stephanie A. Barros , Charles Hendrick , Santhosh Neelamkavil , Raymond J. Patch , Sandeep Somani , Chengzao Sun , Jing Zhang , Elisabetta Bianchi , Danila Branca , Roberto Costante , Raffaele Ingenito , Ashok Bhandari , Brian Frederick , Tran Trung Tran , Jie Zhang
Abstract: The present invention relates to novel bicyclic peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.
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2.发明授权
公开(公告)号：US12018057B2
公开(公告)日：2024-06-25
申请号：US17149544
申请日：2021-01-14
Applicant: Janssen Biotech, Inc. , Protagonist Therapeutics, Inc.
Inventor： Chengzao Sun , Brian Troy Frederick , Sandeep Somani , Ashok Bhandari , Raymond Patch , Stephanie Barros , Raffaele Ingenito , Roberto Costante , Danila Branca , Elisabetta Bianchi
CPC classification number: C07K14/4703 , A61K47/60 , A61K38/00
Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
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3.发明申请
公开(公告)号：US20220402983A1
公开(公告)日：2022-12-22
申请号：US17149544
申请日：2021-01-14
Applicant: Janssen Biotech, Inc. , Protagonist Therapeutics, Inc.
Inventor： Chengzao Sun , Brian Troy Frederick , Sandeep Somani , Ashok Bhandari , Raymond Patch , Stephanie Barros , Raffaele Ingenito , Roberto Costante , Danila Branca , Elisabetta Bianchi
Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
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公开(公告)号：US20240409598A1
公开(公告)日：2024-12-12
申请号：US18579062
申请日：2022-07-14
Applicant: Janssen Biotech, Inc. , Protagonist Therapeutics, Inc.
Inventor： Stephanie A. Barros , Charles Hendrick , Santhosh Neelamkavil , Raymond J. Patch , Sandeep Somani , Chengzao Sun , Jing Zhang , Elisabetta Bianchi , Danila Branca , Roberto Costante , Raffaele Ingenito , Ashok Bhandari , Brian Frederick , James Daniel , Tran Trung Tran
Abstract: The present invention relates to novel cyclic peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders. The inhibitor of an interleukin-23 receptor is cyclized by a disulfide bond between penicillamine, cysteine, homocysteine, or alpha methylcysteine residues at positions X4 and X9.
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5.发明申请
公开(公告)号：US20210261622A1
公开(公告)日：2021-08-26
申请号：US17149509
申请日：2021-01-14
Applicant: Janssen Biotech, Inc. , Protagonist Therapeutics, Inc.
Inventor： Chengzao Sun , Brian Troy Frederick , Sandeep Somani , Gregory Thomas Bourne , Raymond Patch , Ashok Bhandari , Raffaele Ingenito , Roberto Costante , Danila Branca , Elisabetta Bianchi
IPC: C07K7/64
Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
