公开(公告)号：US20080233073A1

公开(公告)日：2008-09-25

申请号：US12055765

申请日：2008-03-26

申请人： Dominique Charmot ,  Han-Ting Chang ,  Mingjun Liu ,  Gerrit Klaerner

发明人： Dominique Charmot ,  Han-Ting Chang ,  Mingjun Liu ,  Gerrit Klaerner

IPC分类号： A61K31/74 ,  A61P3/00

CPC分类号： A61K31/78 ,  A61K9/14 ,  A61K9/1635 ,  A61K9/5026 ,  A61K9/5031 ,  A61K31/74 ,  A61K31/785 ,  A61K31/795 ,  A61K31/80 ,  A61K45/06 ,  C08F120/06 ,  C08F128/02 ,  Y10S514/838 ,  Y10S514/869 ,  Y10S514/87 ,  Y10S514/893

摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.

摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。

公开(公告)号：US07385012B2

公开(公告)日：2008-06-10

申请号：US10701385

申请日：2003-11-03

申请人： Han Ting Chang ,  Dominique Charmot ,  Samir Zard

发明人： Han Ting Chang ,  Dominique Charmot ,  Samir Zard

IPC分类号： C08F26/06 ,  C08K3/00

CPC分类号： C08F26/06

摘要： The present invention provides polymeric and pharmaceutical compositions comprising a polymer that contains vicinal amine moieties, referred to as polyvicinalamine polymers. The polyvicinalamines can be copolymers or homopolymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases, hyperphosphatemia, and the removal of bile acids, oxalates and iron from the gastrointestinal tract.

公开(公告)号：US20080021049A1

公开(公告)日：2008-01-24

申请号：US11579253

申请日：2005-05-03

申请人： Jerry Buysse ,  Dominique Charmot ,  Han-Ting Chang ,  Michael Cope ,  David Hui

发明人： Jerry Buysse ,  Dominique Charmot ,  Han-Ting Chang ,  Michael Cope ,  David Hui

IPC分类号： A61K31/404 ,  A61K31/195 ,  A61K31/381 ,  A61P3/00 ,  A61K31/519 ,  A61K31/40

CPC分类号： A61K31/785 ,  A23L33/10 ,  A61K31/195 ,  A61K31/381 ,  A61K31/40 ,  A61K31/404 ,  A61K31/405 ,  A61K31/519 ,  A61K31/66 ,  A61K31/74

摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a phospholipase A2 inhibitor having comprising a substituted organic compound having a fused five-member ring and six-member ring, such as indole-containing compounds.

摘要翻译： 本发明提供了治疗磷脂酶相关病症的方法和组合物。 特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。 该方法通常包括施用含有具有稠合的五元环和六元环的取代的有机化合物的磷脂酶A2抑制剂，例如含吲哚的化合物。

公开(公告)号：US20060257781A1

公开(公告)日：2006-11-16

申请号：US11300657

申请日：2005-12-12

申请人： Didier Benoit ,  Adam Safir ,  Han-Ting Chang ,  Dominique Charmot ,  Isao Nishimura ,  Akimasa Soyano ,  Kenji Okamoto ,  Yong Wang

发明人： Didier Benoit ,  Adam Safir ,  Han-Ting Chang ,  Dominique Charmot ,  Isao Nishimura ,  Akimasa Soyano ,  Kenji Okamoto ,  Yong Wang

IPC分类号： G03C1/00

CPC分类号： C08F220/18 ,  C08F20/18 ,  C08F220/28 ,  G03F7/0397

摘要： The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.

公开(公告)号：US20060122346A9

公开(公告)日：2006-06-08

申请号：US10877110

申请日：2004-06-25

申请人： Didier Benoit ,  Adam Safir ,  Han-Ting Chang ,  Dominique Charmot ,  Kenji Okamoto ,  Isao Nishimura ,  Yong Wang

发明人： Didier Benoit ,  Adam Safir ,  Han-Ting Chang ,  Dominique Charmot ,  Kenji Okamoto ,  Isao Nishimura ,  Yong Wang

IPC分类号： C08F2/00

CPC分类号： C08F220/30 ,  C08F2/38 ,  C08F20/30 ,  C08F220/18 ,  C08F293/005 ,  G03F7/0046 ,  G03F7/0397

摘要： The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.

摘要翻译： 本发明涉及通过活性自由基聚合技术制备光致抗蚀剂聚合物。 用作单体体积大的酯单体作为聚合组分。 链转移剂的使用包括在聚合工艺条件中。 描述了包含杂原子的聚合物末端基团的切割。

公开(公告)号：US20050165190A1

公开(公告)日：2005-07-28

申请号：US10980935

申请日：2004-11-03

申请人： Han Ting Chang ,  Dominique Charmot ,  Samir Zard

发明人： Han Ting Chang ,  Dominique Charmot ,  Samir Zard

IPC分类号： C08F26/06 ,  C11D1/00

CPC分类号： C08F26/06

摘要： The present invention provides polymeric and pharmaceutical compositions comprising a polymer that contains vicinal amine moieties, referred to as polyvicinalamine polymers. The polyvicinalamines can be copolymers or homopolymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases, hyperphosphatemia, and the removal of bile acids; oxalates and iron from the gastrointestinal tract.

摘要翻译： 本发明提供包含含有连位胺部分的聚合物的聚合物和药物组合物，称为聚酰胺胺聚合物。 聚酰胺可以是共聚物或均聚物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗肾脏疾病，高磷酸血症和去除胆汁酸; 草酸盐和铁从胃肠道。

公开(公告)号：US20050059779A1

公开(公告)日：2005-03-17

申请号：US10689775

申请日：2003-10-20

申请人： Han-Ting Chang ,  Dominique Charmot ,  Damian Hajduk ,  Manikandan Jayaraman ,  Florence Roger ,  Victor Nava-Salgado ,  Adam Safir

发明人： Han-Ting Chang ,  Dominique Charmot ,  Damian Hajduk ,  Manikandan Jayaraman ,  Florence Roger ,  Victor Nava-Salgado ,  Adam Safir

IPC分类号： C08F293/00 ,  C08L53/00

CPC分类号： C08F293/005

摘要： A method for controlling the size of the blocks in a bock copolymer having an olefinic block and a hydrophilic block is disclosed. The method results in block copolymers having novel properties, including the ability to increase the wetability of an olefinic substrate.

摘要翻译： 公开了一种用于控制具有烯烃嵌段和亲水嵌段的嵌段共聚物中嵌段的尺寸的方法。 该方法产生具有新特性的嵌段共聚物，包括增加烯烃基材的润湿性的能力。

公开(公告)号：US06596809B2

公开(公告)日：2003-07-22

申请号：US09910099

申请日：2001-07-20

申请人： Dominique Charmot ,  Manikandan Jayaraman ,  Han Ting Chang ,  Paul Mansky ,  Wilfried Blokzijl

发明人： Dominique Charmot ,  Manikandan Jayaraman ,  Han Ting Chang ,  Paul Mansky ,  Wilfried Blokzijl

IPC分类号： C08G6391

CPC分类号： C08B37/0087 ,  C08B3/22 ,  C08B15/00 ,  C08B37/0057 ,  C08F251/02 ,  C08G18/6484

摘要： Cellulosic polymers, copolymers and grafts, are disclosed that adhere to fibers and surfaces during an aqueous treatment process. The cellulosic polymers having grafts and/or co-blocks are prepared using living-type free radical polymerization techniques, which provides control over the degree of substitution and graft/co-block composition and structure. These cellulosic polymers allow for the modification of fibers and surfaces to provide a desired effect.

公开(公告)号：US06569969B2

公开(公告)日：2003-05-27

申请号：US09963172

申请日：2001-09-25

申请人： Dominique Charmot ,  Han Ting Chang

发明人： Dominique Charmot ,  Han Ting Chang

IPC分类号： C08F404

CPC分类号： C08F2/38

摘要： Control agents that have a nitrogen—nitrogen bond covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization of a wide variety of monomers. These control agents provide superior properties for control of the polymerization and/or the properties of the polymers obtained and/or the monomers that may be polymerized. In some embodiments, a bulky group is pendant off the activated thiocarbonyl portion of the control agents. Multifunctional control agents provide the opportunity for a variety of structurally unique polymers, including block copolymers, stars and hyper-branched polymers.

公开(公告)号：US06518364B2

公开(公告)日：2003-02-11

申请号：US09963235

申请日：2001-09-25

申请人： Dominique Charmot ,  Han Ting Chang ,  Peter Huefner ,  Yunxiao Li

发明人： Dominique Charmot ,  Han Ting Chang ,  Peter Huefner ,  Yunxiao Li

IPC分类号： C08F238

CPC分类号： C08F2/38

摘要： Heterogeneous (e.g., emulsion) polymerization systems include a control agent that has a nitrogen-nitrogen bond covalently bonded to a thiocarbonyl moiety for living-type free radical polymerization of a wide variety of monomers. These control agents provide superior properties for control of the polymerization and/or the properties of the polymers obtained and/or the monomers that may be polymerized. Multifunctional control agents provide the opportunity for a variety of structurally unique polymers, including block copolymers, stars and hyper-branched polymers.