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公开(公告)号：US07342083B2
公开(公告)日：2008-03-11
申请号：US10980935
申请日：2004-11-03
申请人： Han Ting Chang , Dominique Charmot , Samir Zard
发明人： Han Ting Chang , Dominique Charmot , Samir Zard
IPC分类号： C08F12/28
CPC分类号： C08F26/06
摘要： The present invention provides polymeric and pharmaceutical compositions comprising a polymer that contains vicinal amine moieties, referred to as polyvicinalamine polymers. The polyvicinalamines can be copolymers or homopolymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases, hyperphosphatemia, and the removal of bile acids, oxalates and iron from the gastrointestinal tract.
摘要翻译： 本发明提供包含含有连位胺部分的聚合物的聚合物和药物组合物，称为聚酰胺胺聚合物。 聚酰胺可以是共聚物或均聚物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗肾脏疾病，高磷血症，以及从胃肠道中除去胆汁酸，草酸盐和铁。
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公开(公告)号：US07385012B2
公开(公告)日：2008-06-10
申请号：US10701385
申请日：2003-11-03
申请人： Han Ting Chang , Dominique Charmot , Samir Zard
发明人： Han Ting Chang , Dominique Charmot , Samir Zard
CPC分类号： C08F26/06
摘要： The present invention provides polymeric and pharmaceutical compositions comprising a polymer that contains vicinal amine moieties, referred to as polyvicinalamine polymers. The polyvicinalamines can be copolymers or homopolymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases, hyperphosphatemia, and the removal of bile acids, oxalates and iron from the gastrointestinal tract.
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公开(公告)号：US20050165190A1
公开(公告)日：2005-07-28
申请号：US10980935
申请日：2004-11-03
申请人： Han Ting Chang , Dominique Charmot , Samir Zard
发明人： Han Ting Chang , Dominique Charmot , Samir Zard
CPC分类号： C08F26/06
摘要： The present invention provides polymeric and pharmaceutical compositions comprising a polymer that contains vicinal amine moieties, referred to as polyvicinalamine polymers. The polyvicinalamines can be copolymers or homopolymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases, hyperphosphatemia, and the removal of bile acids; oxalates and iron from the gastrointestinal tract.
摘要翻译： 本发明提供包含含有连位胺部分的聚合物的聚合物和药物组合物，称为聚酰胺胺聚合物。 聚酰胺可以是共聚物或均聚物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗肾脏疾病，高磷酸血症和去除胆汁酸; 草酸盐和铁从胃肠道。
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公开(公告)号：US07459502B2
公开(公告)日：2008-12-02
申请号：US10965044
申请日：2004-10-13
申请人： Eric Connor , Dominique Charmot , Han Ting Chang , Florence Roger , Gerrit Klearner , Son Hoai Nguyen
发明人： Eric Connor , Dominique Charmot , Han Ting Chang , Florence Roger , Gerrit Klearner , Son Hoai Nguyen
IPC分类号： C08F26/06
CPC分类号： A61K31/785 , C08L39/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译： 描述了阴离子结合聚合物。 阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。 在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不可用于高于聚合物的靶离子MW的一定百分比的非相互作用溶质。 在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。 还描述了药物组合物，使用方法和试剂盒。
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公开(公告)号：US20080107737A1
公开(公告)日：2008-05-08
申请号：US11577194
申请日：2005-05-11
申请人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
发明人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
IPC分类号： A61K9/14 , A61K31/785 , A61P43/00 , C08F26/04
CPC分类号： A61K31/785 , C08F26/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供包含交联的胺聚合物的聚合物和药物组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗肾脏疾病和高磷酸血症。
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6.发明授权Control agents for living-type free radical polymerization, methods of polymerizing and polymers with same 失效活性自由基聚合的控制剂，聚合方法和与其相同的聚合物公开(公告)号：US06841624B2
公开(公告)日：2005-01-11
申请号：US10406982
申请日：2003-04-03
申请人： Dominique Charmot , Han Ting Chang , Yunxiao Li , Peter Huefner
发明人： Dominique Charmot , Han Ting Chang , Yunxiao Li , Peter Huefner
IPC分类号： C07D231/10 , C07C337/02 , C07C337/04 , C07D285/125 , C08F2/00 , C08F2/38 , C08F4/00 , C08F4/04 , C08F8/00
CPC分类号： C08F2/38
摘要： Control agents that have a nitrogen-nitrogen bond covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization of a wide variety of monomers. These control agents provide superior properties for control of the polymerization and/or the properties of the polymers obtained and/or the monomers that may be polymerized. In some embodiments, a bulky group is pendant off the activated thiocarbonyl portion of the control agents. Multifunctional control agents provide the opportunity for a variety of structurally unique polymers, including block copolymers, stars and hyper-branched polymers.
摘要翻译： 提供了与硫代羰基部分共价连接的氮 - 氮键的对照试剂，用于各种单体的活性自由基聚合。 这些控制剂提供了用于控制聚合的优异性质和/或所获得的聚合物和/或可被聚合的单体的性质。 在一些实施方案中，大体积基团从控制剂的活化的硫代羰基部分脱落。 多功能控制剂为各种结构独特的聚合物，包括嵌段共聚物，恒星和超支化聚合物提供了机会。
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公开(公告)号：US08282960B2
公开(公告)日：2012-10-09
申请号：US10813872
申请日：2004-03-30
申请人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
CPC分类号： A61K9/5031 , A61K9/5026 , A61K9/5047
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
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公开(公告)号：US07776319B2
公开(公告)日：2010-08-17
申请号：US11095760
申请日：2005-03-30
申请人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
发明人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
IPC分类号： A61K31/74 , A61K31/765 , A61K31/785 , A61K9/14 , A61P3/12 , A61P9/12 , A61P13/12
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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9.发明授权公开(公告)号：US07754199B2
公开(公告)日：2010-07-13
申请号：US11734152
申请日：2007-04-11
申请人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
发明人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
CPC分类号： C08G73/02 , C08G73/0206
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供包含交联的胺聚合物的聚合物和药物组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗肾脏疾病和高磷酸血症。
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公开(公告)号：US07556799B2
公开(公告)日：2009-07-07
申请号：US11096209
申请日：2005-03-30
申请人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael J. Cope , Mingjun Liu , Futian Liu , Jerry M. Buysse
发明人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael J. Cope , Mingjun Liu , Futian Liu , Jerry M. Buysse
CPC分类号： A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K45/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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