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769 条记录 (耗时 0.047 秒)

    Substituted 1-amino-4-phenyl-dihydroisoquinolines, methods for the production thereof, use thereof as a medicament, and medicaments containing them
    41.
    发明授权
    Substituted 1-amino-4-phenyl-dihydroisoquinolines, methods for the production thereof, use thereof as a medicament, and medicaments containing them 有权
    取代的1-氨基-4-苯基 - 二氢异喹啉，其制备方法，作为药物的用途，以及含有它们的药物

    公开(公告)号：US08124621B2

    公开(公告)日：2012-02-28

    申请号：US12212301

    申请日：2008-09-17

    申请人： Hans-Jochen Lang ,  John Weston ,  Uwe Heinelt

    发明人： Hans-Jochen Lang ,  John Weston ,  Uwe Heinelt

    IPC分类号： C07D217/22 ,  A61K31/47

    CPC分类号： C07D217/22 ,  C07D401/10

    摘要： The present invention relates to compounds useful in the prevention or treatment of various disorders such as acute or chronic renal failure, for impairments of biliary function, for respiratory impairments such as snoring or sleep apneas or for stroke, and pharmaceutical compositions comprising them. More specifically, the compounds of the present invention comprises substituted 1-amino-4-phenyl-dihydroisoquinolines and their derivatives of formula I: Wherein the substituents R1-R11 are more specifically defined hereinbelow. The claimed compounds of the present invention also include their pharmaceutically acceptable salts and trifluoroacetates thereof as well as methods for their preparation and pharmaceutical delivery systems thereof.

    摘要翻译： 本发明涉及可用于预防或治疗诸如急性或慢性肾衰竭，胆汁功能障碍，呼吸障碍如打鼾或睡眠呼吸暂停或中风的各种疾病的化合物和包含它们的药物组合物。 更具体地，本发明的化合物包括取代的1-氨基-4-苯基 - 二氢异喹啉及其式I的衍生物：其中取代基R 1 -R 11在下文更具体地定义。 所要求保护的本发明化合物还包括其药学上可接受的盐和三氟乙酸盐以及其制备方法和药物递送系统。

    Heterodimers and methods of using them
    50.
    发明授权
    Heterodimers and methods of using them 有权
    异教徒和使用它们的方法

    公开(公告)号：US07605265B2

    公开(公告)日：2009-10-20

    申请号：US11625603

    申请日：2007-01-22

    申请人： Nancy Y Ip ,  Fanny Chui Fun Ip ,  Yueqing Hu ,  Yifan Han ,  Sookja Kim Chung

    发明人： Nancy Y Ip ,  Fanny Chui Fun Ip ,  Yueqing Hu ,  Yifan Han ,  Sookja Kim Chung

    IPC分类号： C07D219/12 ,  C07D217/22

    CPC分类号： C07D401/12

    摘要： Novel heterodimers of tetrahydroacridines and tetrahydroquinolinones are disclosed. The heterodimers are capable of acting as both acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists. The heterodimers may be used to improve cognitive defects via treatment or prevention in both humans and non-humans.

    摘要翻译： 公开了四氢吖啶和四氢喹啉酮的新型异二聚体。 异二聚体能够作为乙酰胆碱酯酶抑制剂和N-甲基-D-天冬氨酸（NMDA）受体拮抗剂。 异源二聚体可用于通过人和非人的治疗或预防来改善认知缺陷。