-
1.发明授权Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof 失效吲唑类，苯并噻唑类，苯并异噻唑类，苯并异恶唑类，吡唑并吡啶类，异噻唑啉类及其制备方法公开(公告)号：US08273891B2
公开(公告)日：2012-09-25
申请号：US12700936
申请日：2010-02-05
申请人： Richard Schumacher , Mihaela Diana Danca , Jianguo Ma , Brian Herbert , True Minh Nguyen , Wenge Xie , Ashok Tehim
发明人： Richard Schumacher , Mihaela Diana Danca , Jianguo Ma , Brian Herbert , True Minh Nguyen , Wenge Xie , Ashok Tehim
IPC分类号： C07D221/02 , C07D217/00
CPC分类号： C07D471/08
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译： 本发明一般涉及烟碱乙酰胆碱受体（nACh受体）的配体领域，nACh受体的活化以及与缺陷或功能异常的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状态的治疗。 此外，本发明涉及作为α7nACh受体亚型的配体的新化合物（例如吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
-
公开(公告)号：US08106066B2
公开(公告)日：2012-01-31
申请号：US11525213
申请日：2006-09-22
申请人： Richard Schumacher , Mihaela Diana Danca , Jianguo Ma , Brian Herbert , True Minh Nguyen , Wenge Xie , Ashok Tehim
发明人： Richard Schumacher , Mihaela Diana Danca , Jianguo Ma , Brian Herbert , True Minh Nguyen , Wenge Xie , Ashok Tehim
IPC分类号： A61K31/44 , C07D221/02 , C07D217/22
CPC分类号： C07D471/08
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
-
3.发明申请INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF 失效辛唑，苯并噻唑，苯并三唑，苯并咪唑，吡唑并吡啶，异亮氨酸，其制备及用途公开(公告)号：US20100137288A1
公开(公告)日：2010-06-03
申请号：US12700936
申请日：2010-02-05
申请人： Richard Schumacher , Mihaela Diana Danca , Jianguo Ma , Brian Herbert , True Minh Nguyen , Wenge Xie , Ashok Tehim
发明人： Richard Schumacher , Mihaela Diana Danca , Jianguo Ma , Brian Herbert , True Minh Nguyen , Wenge Xie , Ashok Tehim
IPC分类号： A61K31/551 , C07D453/02 , A61K31/439 , C07D471/04 , A61K31/437 , C07D513/04 , A61K31/4365 , C07D241/36 , A61K31/498 , C07D487/08 , A61P25/28 , A61P25/32 , A61P25/30 , A61P9/00 , A61P3/10 , A61P3/04 , A61P25/34
CPC分类号： C07D471/08
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译： 本发明一般涉及烟碱乙酰胆碱受体（nACh受体）的配体领域，nACh受体的活化以及与缺陷或功能异常的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状态的治疗。 此外，本发明涉及作为α7nACh受体亚型的配体的新化合物（例如吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
-
4.发明申请1H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF 审中-公开1H-INDAZOLES，BENZOTHIAZOLES，1,2-BENZOISOXAZOLES，1,2-BENZOISOTHIAZOLES AND AND CHROMONES AND Preparation and Preparation and公开(公告)号：US20090325939A1
公开(公告)日：2009-12-31
申请号：US12553538
申请日：2009-09-03
申请人： Wenge XIE , Brian Herbert , Richard A. Schumacher , Jianguo Ma , True Minh Nguyen , Carla Maria Gauss , Ashok Tehim
发明人： Wenge XIE , Brian Herbert , Richard A. Schumacher , Jianguo Ma , True Minh Nguyen , Carla Maria Gauss , Ashok Tehim
IPC分类号： A61K31/551 , C07D243/10 , A61P25/00
CPC分类号： C07D471/08 , C07D487/08
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译： 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及作为α7nAChR亚型的配体的新化合物（吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
-
5.发明申请Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof 失效吲唑类，苯并噻唑类，苯并异噻唑类，苯并异恶唑类，吡唑并吡啶类，异噻唑啉类及其制备方法公开(公告)号：US20070078147A1
公开(公告)日：2007-04-05
申请号：US11525213
申请日：2006-09-22
申请人： Richard Schumacher , Mihaela Danca , Jianguo Ma , Brian Herbert , True Minh Nguyen , Wenge Xie , Ashok Tehim
发明人： Richard Schumacher , Mihaela Danca , Jianguo Ma , Brian Herbert , True Minh Nguyen , Wenge Xie , Ashok Tehim
IPC分类号： C07D471/02 , A61K31/519 , A61K31/4745
CPC分类号： C07D471/08
摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译： 本发明一般涉及烟碱乙酰胆碱受体（nACh受体）的配体领域，nACh受体的活化以及与缺陷或功能异常的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状态的治疗。 此外，本发明涉及作为α7nACh受体亚型的配体的新化合物（例如吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
-
-
-
-
搜索结果
5 条记录 (耗时 0.024 秒)
