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公开(公告)号：US08957063B2
公开(公告)日：2015-02-17
申请号：US12867970
申请日：2009-02-19
Applicant: Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , Monika Ermann , Innocent Mushi
Inventor： Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , Monika Ermann , Innocent Mushi
IPC: A61K31/397 , A61K31/54 , A61K31/5377 , A61K31/4523 , A61K31/4427 , A61K31/44 , A61K31/42 , A61K31/4196 , C07D279/12 , C07D413/00 , C07D413/02 , C07D211/68 , C07D401/02 , C07D405/02 , C07D213/02 , C07D261/06 , C07D261/16 , C07D213/75 , C07D405/12 , C07D413/12
CPC classification number: C07D261/16 , C07D213/75 , C07D405/12 , C07D413/12
Abstract: Compounds which modulate the CB2 receptor are disclosed. The compounds are useful for treating CB2 receptor-mediated diseases such as pain.
Abstract translation: 公开了调节CB2受体的化合物。 该化合物可用于治疗CB2受体介导的疾病如疼痛。
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公开(公告)号：US08846936B2
公开(公告)日：2014-09-30
申请号：US13809607
申请日：2011-07-18
Applicant: Eugene Richard Hickey , Doris Riether , Monika Ermann
Inventor： Eugene Richard Hickey , Doris Riether , Monika Ermann
IPC: C07D213/72 , C07D213/78 , C07D261/04 , C07D261/14 , C07D231/00 , A01N43/40 , A01N43/80 , A61K31/44 , A61K31/42 , C07D277/46 , C07D285/135 , C07D213/74 , C07D413/12 , C07D261/18 , C07D231/38
CPC classification number: C07D285/135 , C07D213/74 , C07D231/38 , C07D261/14 , C07D261/18 , C07D277/46 , C07D413/12
Abstract: Compounds of formula (I) and formula (II) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
Abstract translation: 公开了式（I）和式（II）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US08829034B2
公开(公告)日：2014-09-09
申请号：US13022866
申请日：2011-02-08
Applicant: Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David Thomson , Renee M. Zindell , Nigel Blumire , Chandana Parke , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Malcolm Taylor
Inventor： Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David Thomson , Renee M. Zindell , Nigel Blumire , Chandana Parke , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Malcolm Taylor
IPC: C07D409/04 , C07D309/02 , A61K31/351 , A61K31/42 , C07D261/12 , C07D217/22 , C07D277/82 , C07D309/04 , C07D277/46 , C07C317/44 , C07D213/75 , C07D417/12 , C07D407/12 , C07D405/12 , C07D413/12 , C07D215/38 , C07D403/12 , C07D231/40
CPC classification number: C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
Abstract: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
Abstract translation: 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US08735430B2
公开(公告)日：2014-05-27
申请号：US13627149
申请日：2012-09-26
Applicant: Alessandra Bartolozzi , Eugene Richard Hickey , Doris Riether , Lifen Wu , Renee M. Zindell , Nigel James Blumire , Monika Ermann , Edward Thomas Glenn , Someina Khor , Przemyslaw Zawadzki
Inventor： Alessandra Bartolozzi , Eugene Richard Hickey , Doris Riether , Lifen Wu , Renee M. Zindell , Nigel James Blumire , Monika Ermann , Edward Thomas Glenn , Someina Khor , Przemyslaw Zawadzki
IPC: C07D261/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
CPC classification number: C07D413/12 , C07D261/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
Abstract: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
Abstract translation: 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US08629157B2
公开(公告)日：2014-01-14
申请号：US13141105
申请日：2009-12-15
Applicant: Angela Berry , Rajashekhar Betageri , Eugene Richard Hickey , Someina Khor , Doris Riether , Lifen Wu , Renee M. Zindell
Inventor： Angela Berry , Rajashekhar Betageri , Eugene Richard Hickey , Someina Khor , Doris Riether , Lifen Wu , Renee M. Zindell
IPC: A61K31/506 , A61K31/4439 , A61K31/426 , A61K31/427 , A61K31/421 , A61K31/422 , A61K31/433 , A61K31/4245 , C07D417/12 , C07D417/14 , C07D413/12 , C07D413/14 , C07D401/04
CPC classification number: C07D417/12 , C07D207/16 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain (I).
Abstract translation: 公开了调节CB2受体的化合物。 根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛（I）。
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Patent Agency Ranking
公开(公告)号：US20130184315A1
公开(公告)日：2013-07-18
申请号：US13809607
申请日：2011-07-18
Applicant: Eugene Richard Hickey , Doris Riether , Monika Ermann
Inventor： Eugene Richard Hickey , Doris Riether , Monika Ermann
IPC: C07D285/135 , C07D277/46 , C07D261/14 , C07D261/18 , C07D213/74 , C07D231/38
CPC classification number: C07D285/135 , C07D213/74 , C07D231/38 , C07D261/14 , C07D261/18 , C07D277/46 , C07D413/12
Abstract: Compounds of formula (I) and formula (II) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
Abstract translation: 公开了式（I）和式（II）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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7.发明申请公开(公告)号：US20120010184A1
公开(公告)日：2012-01-12
申请号：US13238054
申请日：2011-09-21
Applicant: Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
Inventor： Alessandra BARTOLOZZI , Angela BERRY , Eugene Richard HICKEY , Markus OSTERMEIER , Doris RIETHER , Achim SAUER , David Smith THOMSON , Lifen WU , Renee M. ZINDELL , Patricia AMOUZEGH , Nigel James BLUMIRE , Stephen Peter EAST , Monika ERMANN , Someina KHOR , Innocent MUSHI
IPC: A61K31/422 , A61K31/433 , A61K31/428 , A61K31/426 , A61K31/42 , A61K31/4196 , C07D401/12 , C07D285/135 , C07D417/12 , C07D413/12 , C07D249/14 , C07D261/14 , C07D403/12 , A61P29/00 , A61K31/454
CPC classification number: C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
Abstract: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
Abstract translation: 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US07935715B2
公开(公告)日：2011-05-03
申请号：US11781336
申请日：2007-07-23
Applicant: Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David S. Thomson , Monika Ermann , James Edward Jenkins , Innocent Mushi , Malcolm Taylor , Christopher Francis Palmer , Nigel Blumire
Inventor： Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David S. Thomson , Monika Ermann , James Edward Jenkins , Innocent Mushi , Malcolm Taylor , Christopher Francis Palmer , Nigel Blumire
IPC: C07D213/75 , C07D403/12 , A61K31/44 , A61P29/00 , A61P37/00 , C07C317/44 , C07C215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D405/12 , C07D407/12
CPC classification number: C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
Abstract: Compound of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
Abstract translation: 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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9.发明授权公开(公告)号：US06649642B2
公开(公告)日：2003-11-18
申请号：US10278546
申请日：2002-10-23
Applicant: Younes Bekkali , Eugene Richard Hickey , Weimin Liu , David S. Thomson
Inventor： Younes Bekkali , Eugene Richard Hickey , Weimin Liu , David S. Thomson
IPC: A61K314184
CPC classification number: C07D295/185 , C07B2200/07 , C07C255/31 , C07C2601/02 , C07C2601/14 , C07C2601/18 , C07C2602/20 , C07D207/16 , C07D211/66 , C07D403/06 , C07D405/04 , C07D409/06
Abstract: Disclosed are novel succinate derivative compounds of the formula(I)/(Ia): wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.
Abstract translation: 公开了式（I）/（Ia）的新型琥珀酸酯衍生物化合物：其中R1，R2，R3，R4，R5，R6，R7，X和A如本文所定义。 该化合物可用作半胱氨酸蛋白酶的抑制剂。 还公开了使用方法和制备这些化合物的方法。
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公开(公告)号：US08362039B2
公开(公告)日：2013-01-29
申请号：US13217480
申请日：2011-08-25
Applicant: Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Markus Ostermeier , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
Inventor： Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Markus Ostermeier , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
IPC: A61K31/4525 , A61K31/4196 , A61K31/422 , A61K31/433
CPC classification number: C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
Abstract: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
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