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![Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C](/abs-image/US/2015/04/07/US08999975B2/abs.jpg.150x150.jpg)
1.发明授权Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C 有权取代的组织蛋白酶C的N- [1-氰基-2-（苯基）乙基] -2-氮杂双环[2.2.1]庚烷-3-甲酰胺抑制剂公开(公告)号：US08999975B2
公开(公告)日：2015-04-07
申请号：US13615781
申请日：2012-09-14
申请人： Marc Grundl , Thorsten Oost , Alexander Pautsch , Stefan Peters , Doris Riether , Wolfgang Wienen
发明人： Marc Grundl , Thorsten Oost , Alexander Pautsch , Stefan Peters , Doris Riether , Wolfgang Wienen
IPC分类号： C07D209/52 , A61K31/416 , A61K31/4178 , A61K31/437 , C07D519/00 , A61K31/538 , A61K31/4709 , C07D495/04 , A61K31/4725 , A61K31/536 , C07D401/14 , A61K31/551 , A61K31/501 , A61K31/4439 , A61K31/4365 , A61K31/404 , A61K45/06 , A61K31/506 , A61K31/4184 , A61K31/454 , C07D401/12 , C07D471/04 , A61K31/4155 , A61K31/4192 , C07D413/12 , A61K31/4035 , A61K31/428 , A61K31/423 , A61K31/403 , C07D405/12 , C07D471/08 , C07D487/04 , A61K31/496 , A61K31/497 , C07D403/12 , C07D417/12 , A61K31/4985 , A61K31/4245 , A61K31/517
CPC分类号： C07D209/52 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/4245 , A61K31/428 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/536 , A61K31/538 , A61K31/551 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D495/04 , C07D519/00
摘要： The present invention is directed to compounds of Formula I: wherein R1, R2 and n are described herein. These compounds and their pharmaceutically acceptable salts thereof are inhibitors of Cathepsin C.
摘要翻译： 本发明涉及式I化合物：其中R1，R2和n在本文中描述。 这些化合物及其药学上可接受的盐是组织蛋白酶C的抑制剂
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公开(公告)号：US08889670B2
公开(公告)日：2014-11-18
申请号：US13147432
申请日：2010-02-16
申请人： Alessandra Bartolozzi , Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , Lifen Wu , Renee M. Zindell
发明人： Alessandra Bartolozzi , Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , Lifen Wu , Renee M. Zindell
IPC分类号： A61K31/4545 , C07D211/60 , C07D401/12 , C07D405/04 , C07D413/12 , C07D417/12 , C07D417/14
CPC分类号： C07D413/12 , C07D211/60 , C07D401/12 , C07D405/04 , C07D417/12 , C07D417/14
摘要： Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了调节CB2受体的化合物。 根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US08575201B2
公开(公告)日：2013-11-05
申请号：US13237112
申请日：2011-09-20
申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin W. Liu , Pui Leng Loke , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin W. Liu , Pui Leng Loke , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号： C07D413/14
摘要： The present invention relates to compounds of formula (I) and (IA): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）和（IA）化合物及其药学上可接受的盐，其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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4.发明授权公开(公告)号：US08383615B2
公开(公告)日：2013-02-26
申请号：US13376203
申请日：2010-06-08
IPC分类号： A61K31/397 , C07D413/14 , C07D417/14 , C07D405/04
CPC分类号： C07D405/06 , C07D405/04 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Compounds of the formula (I), (II) and (III) which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了调节CB2受体的式（I），（II）和（III）的化合物。 根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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5.发明授权公开(公告)号：US08349871B2
公开(公告)日：2013-01-08
申请号：US13238054
申请日：2011-09-21
申请人： Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
发明人： Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
IPC分类号： A61K31/454 , A61K31/4196 , A61K31/422 , A61K31/42 , A61K31/427 , C07D401/12 , C07D285/135 , C07D261/14 , C07D249/14 , C07D277/46 , C07D277/62
CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US08299111B2
公开(公告)日：2012-10-30
申请号：US12956322
申请日：2010-11-30
申请人： Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David S. Thomson , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Nigel Blumire
发明人： Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David S. Thomson , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Nigel Blumire
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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7.发明申请公开(公告)号：US20120142666A1
公开(公告)日：2012-06-07
申请号：US13376203
申请日：2010-06-08
IPC分类号： A61K31/397 , C07D413/14 , C07D417/14 , C07D405/04 , A61K31/422 , A61K31/433 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/541 , A61P11/00 , A61P37/00 , A61P21/00 , A61P37/08 , A61P9/00 , A61P17/00 , A61P13/12 , A61P1/16 , A61P1/00 , A61P27/02 , A61P27/16 , A61P1/02 , A61P25/00 , A61P7/00 , A61P35/00 , A61P5/00 , A61P29/00 , A61P9/10 , A61P9/04 , C07D405/06
CPC分类号： C07D405/06 , C07D405/04 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Compounds of the formula (I), (II) and (III) which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了调节CB2受体的式（I），（II）和（III）的化合物。 根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US08178568B2
公开(公告)日：2012-05-15
申请号：US13002659
申请日：2009-06-24
申请人： John Regan , Doris Riether
发明人： John Regan , Doris Riether
IPC分类号： A61K31/422 , A61K31/4015 , A61K31/4025 , C07D207/12
CPC分类号： C07D413/04 , C07D261/14 , C07D285/08 , C07D401/04 , C07D403/04 , C07D413/12 , C07D413/14 , C07D417/04
摘要： Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了调节CB2受体的化合物。 根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US07928103B2
公开(公告)日：2011-04-19
申请号：US12444919
申请日：2007-10-15
IPC分类号： A61K31/535 , C07D413/00
CPC分类号： C07D265/30 , C07D413/06 , C07D413/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物是CB2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号：US20110071127A1
公开(公告)日：2011-03-24
申请号：US12956322
申请日：2010-11-30
申请人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher Francis PALMER , Nigel BLUMIRE
发明人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher Francis PALMER , Nigel BLUMIRE
IPC分类号： A61K31/5377 , C07D261/14 , A61K31/42 , C07D213/70 , A61K31/4402 , C07C321/28 , A61K31/216 , C07D277/36 , A61K31/426 , C07D413/12 , A61K31/4439 , C07D309/08 , A61K31/351 , C07D417/14 , C07D413/14 , A61P29/00 , A61P1/00 , A61P25/28 , A61P35/00 , A61P37/06
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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