公开(公告)号：US11998662B1

公开(公告)日：2024-06-04

申请号：US18448259

申请日：2023-08-11

申请人： Reprise Biomedical, Inc.

发明人： Jason Isenburg ,  Kyle Bettinger

IPC分类号： A61L27/56 ,  A61L27/36 ,  A61L27/54

CPC分类号： A61L27/56 ,  A61L27/3683 ,  A61L27/54 ,  A61L2300/404 ,  A61L2430/34

摘要： A method for augmenting a void or treating a wound in a body cavity involves applying a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized mammalian tissue or organ to the site of the void or body cavity. This application allows for cellular infiltration, integration, or remodeling of the surrounding body tissue into one or more vascular pathways of the scaffold. The scaffold is applied in a manner that ensures at least three surfaces of the scaffold make contact with the surrounding body tissue. The scaffold includes a plurality of pores, resulting in a surface area significantly larger than a poreless scaffold of the same outer dimensions. The method can also include placing milled fibers to any undermining or irregularities in the void or cavity before applying the scaffold.

公开(公告)号：US11998660B2

公开(公告)日：2024-06-04

申请号：US16795770

申请日：2020-02-20

申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN

发明人： Daniel John Kelly ,  Grainne Cunniffe ,  Henrique Almeida ,  Rajalakshmanan Eswaramoorthy ,  Conor Buckley ,  Pedro Jose Diaz Payno ,  David Browe

IPC分类号： A61L27/50 ,  A61L27/36 ,  A61L27/38 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58

CPC分类号： A61L27/3633 ,  A61L27/3612 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/40

摘要： A method for making a porous devitalised scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal comprises the steps of providing micronized extracellular matrix (ECM) tissue, mixing the micronized extracellular matrix with a liquid to provide a slurry, and freeze-drying the slurry to provide the porous scaffold. A porous scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal and comprising a porous freeze-dried matrix formed from micronised decellularised extracellular matrix tissue is also described.

公开(公告)号：US20240165046A1

公开(公告)日：2024-05-23

申请号：US18282545

申请日：2022-01-28

申请人： Aalto University Foundation sr

发明人： Jani Kuula ,  Eija Raussi-Lehto ,  Orlando Rojas ,  Rubina Ajdary ,  Tomi Mikkola

IPC分类号： A61K9/70 ,  A61K9/00 ,  A61K31/717 ,  A61L27/20 ,  A61L27/54

CPC分类号： A61K9/70 ,  A61K9/0024 ,  A61K31/717 ,  A61L27/20 ,  A61L27/54 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/22 ,  A61L2430/34

摘要： According to an example aspect of the present invention, there is provided a composition for use in the treatment of urinary or faecal incontinence, the composition comprising a nanostructured cellulosic material.

公开(公告)号：US11980534B2

公开(公告)日：2024-05-14

申请号：US16524473

申请日：2019-07-29

申请人： The Johns Hopkins University ,  Rensselaer Polytechnic Institute

发明人： Andres Hurtado ,  Ryan James Gilbert ,  Han Bing Wang ,  Jared M. Cregg ,  Michael E. Mullins ,  Martin Oudega

IPC分类号： A61F2/00 ,  A61L27/18 ,  A61L27/38 ,  A61L27/54 ,  D01D5/00 ,  D06M16/00 ,  A61F2/04

CPC分类号： A61F2/00 ,  A61F2/0063 ,  A61L27/18 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/54 ,  D01D5/0076 ,  D06M16/003 ,  A61F2/04 ,  A61L2300/254 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2430/32 ,  A61L2430/38 ,  A61L27/18 ,  C08L67/04

摘要： One aspect of the invention provides a three-dimensional scaffold including at least one layer of highly-aligned fibers. The at least one layer of highly-aligned fibers is curved in a direction substantially perpendicular to a general direction of the fibers. Another aspect of the invention provides a method for fabricating a three-dimensional scaffold. The method includes: electro spinning a plurality of fibers to produce at least one layer of highly-aligned fibers and forming the at least one layer of highly-aligned fibers into a three-dimensional scaffold without disturbing the alignment of the highly-aligned polymer fibers. A further aspect of the invention provides methods for using a three-dimensional scaffold to treat nerve or spinal cord injury.

公开(公告)号：US20240148643A1

公开(公告)日：2024-05-09

申请号：US18236215

申请日：2023-08-21

申请人： Allergan, Inc.

发明人： Michael R. Robinson ,  James A. Burke ,  Rhett M. Schiffman ,  Alazar N. Ghebremeskel

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K31/5575 ,  A61K47/10 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61K9/0051 ,  A61K9/0024 ,  A61K9/1647 ,  A61K31/5575 ,  A61K47/10 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

摘要： Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.

公开(公告)号：US11974794B2

公开(公告)日：2024-05-07

申请号：US17352096

申请日：2021-06-18

申请人： Ernesto A. Lee

发明人： Ernesto A. Lee

IPC分类号： A61B17/88 ,  A61L27/36 ,  A61L27/58 ,  A61F2/28 ,  A61L27/54

CPC分类号： A61B17/8825 ,  A61B17/8816 ,  A61L27/3608 ,  A61L27/58 ,  A61F2002/2835 ,  A61L27/54 ,  A61L2400/06 ,  A61L2430/02

摘要： A subperiosteal syringe assembly for storing, containing and delivering bone graft material to a location within the tissue of a jaw for use in a medical procedure. The syringe assembly has a lumen body that is maneuverable within the subperiosteal tissue to deposit bone graft material at the desired surgical site. Embodiments include a lumen body that has a flat shape, such as an elliptical shape. A plunger is provided to deliver the syringe contents. The syringe may be loaded with bone graft material, and some embodiments may be supplied pre-loaded with bone graft material. An end cap seals the open end of the lumen, and may function as a septum that may be punctured with a needle to introduce a liquid substance, such as a growth factor, into the lumen where the bone material is stored. The syringe may be designed to incorporate surgical navigation and laparoscopic systems.

公开(公告)号：US20240139379A1

公开(公告)日：2024-05-02

申请号：US18108395

申请日：2023-02-10

申请人： The Research Foundation for the State University of New York

发明人： Susan Sharfstein ,  Yubing Xie ,  Pujhitha Ramesh ,  James Castracane ,  Melinda Larsen ,  Nicholas Moskwa

IPC分类号： A61L27/52 ,  A61L27/26 ,  A61L27/38 ,  A61L27/54 ,  C08L5/04 ,  C08L89/06

CPC分类号： A61L27/52 ,  A61L27/26 ,  A61L27/3834 ,  A61L27/54 ,  C08L5/04 ,  C08L89/06 ,  A61L2300/414 ,  A61L2430/34

摘要： The present disclosure relates to compositions, apparatus and methods for generating one or more scaffolds, including: mixing a hydrogel material and/or an extracellular matrix (ECM) protein in an aqueous solvent to generate an aqueous process solution; and cryoelectrospinning the aqueous process solution onto a plurality of conductive probes extending from a conductive surface of a collector plate disposed within a process chamber under conditions sufficient to generate one or more scaffolds configured to mimic a preselected soft tissue decellularized extracellular matrix. Scaffold compositions are also provided having preselected or tuned characteristics. The scaffolds provide a promising stromal cell delivery vehicle for the remediation of fibrosis.

公开(公告)号：US20240139372A1

公开(公告)日：2024-05-02

申请号：US18450941

申请日：2023-08-16

申请人： Abbott Cardiovascular Systems, Inc

发明人： Ni Ding ,  Vincent James Gray

IPC分类号： A61L27/18 ,  A61L27/54

CPC分类号： A61L27/18 ,  A61L27/54 ,  A61L2420/06

摘要： Systems, methods, and apparatuses for depositing polymer and/or other layers onto surfaces of, for example, implantable medical devices. In some embodiments, the polymer and/or other coating layers are deposited via plasma polymerization deposition. In some embodiments, primer layers are deposited via plasma polymerization deposition. A coating layer can be formed over a primer layer. The deposited layers can be bioresorbable and/or bioabsorbable.

公开(公告)号：US11969524B2

公开(公告)日：2024-04-30

申请号：US18150454

申请日：2023-01-05

申请人： Ethicon, Inc.

发明人： Duan Li Ou ,  Christophe Vailhe ,  Frank R. Cichocki, Jr.

IPC分类号： A61L27/54 ,  A61L2/03 ,  A61L2/07 ,  A61L2/20 ,  A61L2/26 ,  A61L17/00 ,  A61L17/14 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  B05B7/16 ,  B05B12/08 ,  B05B15/00 ,  B05B17/06 ,  B05D1/02 ,  B05D3/04 ,  C09D5/14 ,  C09D7/20 ,  C09D7/62 ,  C09D183/04 ,  C10M107/50 ,  A61M11/00 ,  C10N30/16 ,  C10N40/00 ,  C10N50/08

CPC分类号： A61L27/54 ,  A61L2/03 ,  A61L2/07 ,  A61L2/20 ,  A61L2/26 ,  A61L17/005 ,  A61L17/145 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  B05B7/1606 ,  B05B7/1686 ,  B05B12/081 ,  B05B15/00 ,  B05B17/0615 ,  B05D1/02 ,  B05D3/0493 ,  C09D5/14 ,  C09D7/20 ,  C09D7/62 ,  C09D183/04 ,  C10M107/50 ,  A61L2202/181 ,  A61L2202/182 ,  A61L2300/202 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2420/06 ,  A61M11/005 ,  C10M2229/0445 ,  C10N2030/16 ,  C10N2040/50 ,  C10N2050/08

摘要： Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability and are readily applied in coating processes a low temperatures that do not deform the device. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

公开(公告)号：US11969349B2

公开(公告)日：2024-04-30

申请号：US17199920

申请日：2021-03-12

申请人： Collagen Matrix, Inc.

发明人： Shu-Tung Li ,  Hui-Chen Chen ,  Debbie Yuen

IPC分类号： A61F2/28 ,  A61F2/30 ,  A61L27/12 ,  A61L27/24 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61L27/12 ,  A61L27/24 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/54 ,  A61L27/58 ,  A61F2002/2839 ,  A61F2002/30016 ,  A61F2002/30062 ,  A61F2002/30293 ,  A61F2002/3092 ,  A61F2310/00371 ,  A61L2430/02 ,  A61L2430/06

摘要： An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.