公开(公告)号：US09782774B2

公开(公告)日：2017-10-10

申请号：US14463865

申请日：2014-08-20

Applicant: Daktari Diagnostics, Inc.

Inventor： Lee Zamir ,  Aaron Oppenheimer ,  Lutz Weber

IPC: B01L3/00

CPC classification number: B01L3/502738 ,  B01L3/502723 ,  B01L3/502776 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  Y10T436/2575

Abstract: This document provides methods and devices for metering fluids. In some cases, the methods and devices include intersecting channels that include capillary-stop geometries at each intersection point that guides the fluids on a desired path, which is controlled by the opening and closing of valves. For example, a metering channel can intersect a loading channel and intersect an outflow channel and a metering portion can be defined by the geometry of the metering channel between the intersection points.

公开(公告)号：US09757722B2

公开(公告)日：2017-09-12

申请号：US14741114

申请日：2015-06-16

Applicant: PANASONIC HEALTHCARE HOLDINGS CO., LTD.

Inventor： Tomohiro Kijima

IPC: B01L3/00 ,  G01N21/07 ,  G01N33/02 ,  G01N35/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/15 ,  A61B5/157 ,  G01N35/04

CPC classification number: B01L3/502 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/157 ,  B01L3/5021 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/06 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2300/046 ,  B01L2300/047 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  G01N21/07 ,  G01N33/02 ,  G01N35/00029 ,  G01N2035/00237 ,  G01N2035/0449 ,  Y10T436/111666

Abstract: An analyzing device has a main body and is configured to draw a sample liquid from a spot application section of the main body and transfer the sample liquid to a measurement chamber via a microchannel structure formed inside the main body by a centrifugal force. The spot application section has an inlet. The analyzing device includes a supplying capillary channel formed within the spot application section. The supplying capillary channel has an end connected to the inlet of the spot application section. The analyzing device also includes a holding chamber connected to another end of the supplying capillary channel and having a thickness sized to generate a capillary force to move the sample liquid. The holding chamber is formed between a first side wall and a second side wall. The first side wall and the second side wall define the holding chamber.

公开(公告)号：US09731297B2

公开(公告)日：2017-08-15

申请号：US13343834

申请日：2012-01-05

Applicant: Eli N. Glezer ,  Stephen Higgins ,  Sandor Kovacs ,  Sudeep Kumar ,  Kenneth Page ,  Kristian Roth ,  George Sigal

Inventor： Eli N. Glezer ,  Stephen Higgins ,  Sandor Kovacs ,  Sudeep Kumar ,  Kenneth Page ,  Kristian Roth ,  George Sigal

IPC: C12M1/40 ,  C12Q1/68 ,  B01L7/00 ,  B01L3/00

CPC classification number: B01L7/525 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2200/146 ,  B01L2200/16 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/0694 ,  C12Q1/686

Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20170219614A1

公开(公告)日：2017-08-03

申请号：US15500481

申请日：2015-07-28

Applicant: DOUGLAS SCIENTIFIC, LLC

Inventor： DARREN LYNN COOK ,  ERIC GUY JOHNSON ,  NATHAN LUTHER WESTAD ,  ANDREW RICHARD HAUG ,  JAMES HENRY KONYNENBELT ,  GRANT EDWARD MAASJO ,  JARED WHITTIER PATTERSON ,  BRENT CONRAD URKE ,  RYAN JOHN ZITZMANN ,  CHAD STEVEN SMITH

IPC: G01N35/00 ,  B01L3/00 ,  G01N35/04 ,  C12Q1/68 ,  G01N35/10 ,  B01L7/00

CPC classification number: G01N35/00009 ,  B01L3/502 ,  B01L3/50851 ,  B01L7/52 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2200/14 ,  B01L2300/021 ,  B01L2300/0627 ,  B01L2300/0812 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/1827 ,  C12Q1/686 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2035/00148 ,  G01N2035/00346 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00445 ,  G01N2035/0405 ,  G01N2035/0422 ,  G01N2035/0425 ,  G01N2035/0465

Abstract: An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.

公开(公告)号：US20170203022A1

公开(公告)日：2017-07-20

申请号：US15474849

申请日：2017-03-30

Applicant: NXSTAGE MEDICAL, INC.

Inventor： Jeffrey H. BURBANK ,  James M. BRUGGER

IPC: A61M1/16 ,  B65B3/28 ,  B65B55/04 ,  F16L55/07 ,  B01D61/14 ,  C02F1/44 ,  B01L3/00 ,  B65B3/30 ,  A61M1/34

CPC classification number: A61M1/1668 ,  A61J1/05 ,  A61J1/1468 ,  A61J1/1475 ,  A61J1/2003 ,  A61M1/14 ,  A61M1/1656 ,  A61M1/167 ,  A61M1/1672 ,  A61M1/1674 ,  A61M1/28 ,  A61M1/3413 ,  A61M1/342 ,  A61M1/3462 ,  A61M39/1011 ,  A61M39/288 ,  A61M2205/273 ,  B01D61/14 ,  B01D61/142 ,  B01D61/145 ,  B01D63/00 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2300/0681 ,  B01L2300/0864 ,  B65B3/28 ,  B65B3/30 ,  B65B55/04 ,  C02F1/444 ,  C02F2103/026 ,  F16K7/068 ,  F16L55/00 ,  F16L55/07 ,  Y10T137/8593

Abstract: A system that fills multiple containers includes a filter with an inlet port and multiple outlet ports. The outlet ports are pre-attached to containers by respective filling lines of each container. Each container has an interior and each of the respective filling lines is connected to a respective container interior. All of the respective filling lines are sealed to the outlet ports and the containers such that the container interiors are isolated from an external environment except the inlet port, via the filter, forming a combined interior volume which is sterile. The system can produce batches of multiple sterile containers with sterile medicament in the containers.

公开(公告)号：US09707561B2

公开(公告)日：2017-07-18

申请号：US15038024

申请日：2014-11-19

Applicant: Randox Laboratories Ltd.

Inventor： Jonathan Matear ,  Robson Pang ,  Stuart Jackson ,  David Sloan

IPC: G01N35/10 ,  G01N35/04 ,  F04B9/04 ,  B01L3/00 ,  G01N1/38 ,  G01N35/00

CPC classification number: B01L3/50273 ,  B01L3/502715 ,  B01L3/527 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  F04B9/042 ,  G01N35/00029 ,  G01N35/1002 ,  G01N2035/00148 ,  G01N2035/0486

Abstract: There is provided an assay fluid delivery system comprising an array of fluid reservoirs (62), each of which is selectively actuatable to deliver a respective fluid to a fluid channel structure; and a fluid delivery control system (50) comprising a plurality of reciprocally mounted actuators, each associated with a respective reservoir and being movable between a retracted position and an actuating position at which it causes fluid to be delivered from the corresponding reservoir, a plurality of cams (22) with different profiles mounted on a common, rotatable cam shaft (6), each cam being engaged with a respective one of the actuators whereby rotation of the cams causes movement of the corresponding actuators between the retracted and actuating positions, and a motor coupled to the cam shaft for rotating the cam shaft, wherein the cams are shaped relative to one another so as to cause the corresponding actuators to actuate the reservoirs in a predetermined sequence and for predetermined respective times.

公开(公告)号：US09687842B2

公开(公告)日：2017-06-27

申请号：US14370053

申请日：2012-01-20

Applicant: Saburo Ito

Inventor： Saburo Ito

IPC: B01L3/02 ,  G01N1/40

CPC classification number: B01L3/0275 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/0681 ,  B01L2300/0858 ,  B01L2400/0605 ,  B01L2400/0616 ,  B01L2400/0633 ,  G01N2001/4088

Abstract: A suction tip includes a tip opening, a tubular passage provided with a first selector configured to permit the passage of non-selection subjects included in a collection of subjects sucked through the tip opening, and a capture portion provided on a side of the tubular passage downstream of the first selector in a suction direction of the collection of subjects and configured to capture the non-selection subjects. The capture portion includes a passage hole configured to permit the passage of the non-selection subjects and a storage portion configured to store the non-selection subjects having passed through.

公开(公告)号：US09649628B2

公开(公告)日：2017-05-16

申请号：US14781569

申请日：2014-04-01

Applicant: GILSON SAS

Inventor： Bruno Dudek

IPC: B01L3/02

CPC classification number: B01L3/0224 ,  B01L3/0227 ,  B01L2200/0605 ,  B01L2400/0478

Abstract: A device for controlling pipetting and adjusting a volume to be sampled, including a pipetting control member; rotary actuating means coupled to the control member; a linking member slidably mounted on the actuating means, the linking member being connected to a piston; volume adjusting means; rotary means defining, for the linking member, a spiral-shaped guiding path, the rotary means being coupled to the adjusting means so that their actuation causes a rotation of the means about a second axis which the guiding path is centered, this rotation leading to a displacement of the linking member along the path, and to a sliding of the member relative to the actuating means.

公开(公告)号：US20170128938A9

公开(公告)日：2017-05-11

申请号：US14689508

申请日：2015-04-17

Applicant: CYTONOME/ST, LLC

Inventor： John R. Gilbert ,  Sebastian Böhm ,  Manish Deshpande

IPC: B01L3/00 ,  F16K99/00

CPC classification number: B01L3/502746 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2400/06 ,  B01L2400/082 ,  F16K99/0019 ,  F16K99/0061 ,  F16K2099/0084

Abstract: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.

公开(公告)号：US20170121659A1

公开(公告)日：2017-05-04

申请号：US15403944

申请日：2017-01-11

Applicant: President and Fellows of Harvard College

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Daniel Levner ,  Guy Thompson ,  Hubert Geisler ,  Jose Fernandez-Alcon ,  Donald E. Ingber

IPC: C12M3/06 ,  C12M1/34 ,  C12M3/00 ,  B01L3/00

CPC classification number: C12M23/16 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y15/00 ,  C12M21/08 ,  C12M33/12 ,  C12M41/00 ,  C12M41/40 ,  C12M41/46 ,  G01N33/5005

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.