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    Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers
    44.
    发明授权
    Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers 有权
    腹膜内施用的纳米载体，其基于癌症的炎症环境释放其治疗负荷

    公开(公告)号：US09532949B2

    公开(公告)日：2017-01-03

    申请号：US14233527

    申请日：2012-07-18

    Applicant: Reema Zeineldin

    Inventor： Reema Zeineldin

    IPC: A61K9/51 ,  A61K9/127 ,  A61K31/704 ,  A61K9/00

    CPC classification number: A61K9/127 ,  A61K9/0019 ,  A61K9/5115 ,  A61K9/5153 ,  A61K31/704 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907 ,  Y10S977/911

    Abstract: In one embodiment, the invention provides a new design of nanocarrier compositions that release their therapeutic load specifically at intraperitoneal cancers' site. These nanocarriers are administered intraperitoneally and comprise a plurality of porous nanoparticulates that (a) are loaded with one or more pharmaceutically-active agents alone or in combination with imaging agents thus providing a theranostic value and (b) that are encapsulated by and that support a lipid bilayer which is disrupted upon contact with a reactive oxygen species generated within the environment of the cancer. In other embodiments, the invention provides methods of treatment and pharmaceutical compositions comprising nanocarriers as described herein.

    Abstract translation: 在一个实施方案中，本发明提供纳米载体组合物的新设计，其特别在腹膜内癌症部位释放其治疗负荷。 这些纳米载体被腹膜内施用并且包含多个多孔纳米颗粒，其（a）单独或与成像剂组合加载一种或多种药物活性剂，从而提供神经元值，并且（b）被包囊并支持 脂质双层在与癌症环境中产生的活性氧物质接触时被破坏。 在其它实施方案中，本发明提供了治疗方法和包含如本文所述的纳米载体的药物组合物。

    Cathode catalysts for fuel cell application derived from polymer precursors
    45.
    发明授权
    Cathode catalysts for fuel cell application derived from polymer precursors 有权
    用于燃料电池应用的阴极催化剂衍生自聚合物前体

    公开(公告)号：US09502719B2

    公开(公告)日：2016-11-22

    申请号：US14126565

    申请日：2012-06-15

    Applicant: Alexey Serov ,  Barr Halevi ,  Michael Robson ,  Wendy Patterson ,  Kateryna Artyushkova ,  Plamen B Atanassov

    Inventor： Alexey Serov ,  Barr Halevi ,  Michael Robson ,  Wendy Patterson ,  Kateryna Artyushkova ,  Plamen B Atanassov

    IPC: B01J27/00 ,  B01J27/24 ,  H01M4/90 ,  H01M4/86

    CPC classification number: H01M4/9091 ,  H01M4/90 ,  H01M2004/8689 ,  Y02E60/50

    Abstract: A method of preparing M-N—C catalysts utilizing a sacrificial support approach and inexpensive and readily available polymer precursors as the source of nitrogen and carbon is disclosed. Exemplary polymer precursors include those that do not form complexes with iron, but which do complex with silica, for example, polyetheleneimine (PEI), Poly(2-ethyl-2-oxazoline), Poly(acrylamide-co-diallyldimethylammonium chloride), Poly(melamine-co-formaldehyde), Poly[[6-[(1,1,3,3-tetramethylbutyl)amino]-s-triazine-2,4-diyl]-[(2,2,6,6-tetramethyl-4-piperidyl)imino]-hexamethylene-[(2,2,6,6-tetramethyl-4-piperidyl)imino] and the like.

    Abstract translation: 公开了一种使用牺牲支撑方法制备M-N-C催化剂的方法，并且公开了廉价且容易获得的聚合物前体作为氮和碳的来源。 示例性聚合物前体包括不与铁形成络合物但与二氧化硅络合的那些，例如聚乙烯亚胺（PEI），聚（2-乙基-2-恶唑啉），聚（丙烯酰胺 - 共二烯丙基二甲基氯化铵），聚 （三聚氰胺 - 共 - 甲醛），聚[[6 - [（1,1,3,3-四甲基丁基）氨基] -s-三嗪-2,4-二基] - [（2,2,6,6-四甲基 -4-哌啶基）亚氨基] - 六亚甲基 - [（2,2,6,6-四甲基-4-哌啶基）亚氨基]等。

    Signal propagation biomolecules, devices and methods
    46.
    发明授权
    Signal propagation biomolecules, devices and methods 有权
    信号传播生物分子，装置和方法

    公开(公告)号：US09476090B2

    公开(公告)日：2016-10-25

    申请号：US14283993

    申请日：2014-05-21

    Applicant: STC.UNM

    Inventor： Carl Brown, III ,  Steven Wayde Graves ,  Darko Stefanovic ,  Matthew Richard Lakin

    IPC: C07H21/04 ,  C12Q1/68 ,  C07H21/02

    CPC classification number: C12Q1/6816 ,  C12Q2521/345 ,  C12Q2525/301 ,  C12Q2565/1015

    Abstract: This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains. A first domain acts as a toehold for an input DNA logic gate to initiate binding to an SCS biomolecule. A second domain acts as a substrate recognition sequence for an upstream DNA logic gate. A third domain acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate. A fourth domain acts as an effector sequence to alter the state of the output logic gate. A fifth domain acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.

    Abstract translation: 本公开描述了结构化多核苷酸，包括结构化多核苷酸的装置和涉及结构化多核苷酸和/或装置的方法。 通常，结构化多核苷酸包括五个结构域。 第一个域用作输入DNA逻辑门的始发点，以启动与SCS生物分子的结合。 第二个域用作上游DNA逻辑门的底物识别序列。 第三个域用作输出DNA逻辑门的脚注，以启动SCS生物分子与门的结合。 第四个域用作效应序列来改变输出逻辑门的状态。 第五结构域充当笼状序列，以将效应序列锁定在无活性状态，直到输入门结合结构化多核苷酸。

    SYSTEM AND METHODS FOR MANAGING CONGESTIVE HEART FAILURE
    48.
    发明申请
    SYSTEM AND METHODS FOR MANAGING CONGESTIVE HEART FAILURE 审中-公开
    用于管理心绞痛失败的系统和方法

    公开(公告)号：US20160171174A1

    公开(公告)日：2016-06-16

    申请号：US14907426

    申请日：2014-08-15

    Applicant: STC.UNM

    Inventor： Glen H. Murata

    IPC: G06F19/00 ,  G06F17/30

    CPC classification number: G06F16/283 ,  G16H10/20 ,  G16H50/20 ,  G16H50/70

    Abstract: The invention is a multi-purpose system and methods that focuses on the prevention of congestive heart failure (CHF) exacerbations by identifying the population at risk, examining their use of medications that optimize ventricular function, tracking weight changes through different phases of illness, and retrieving vital sign and laboratory data needed for treatment intensification.

    Abstract translation: 本发明是一种多用途系统和方法，其重点是通过识别处于危险中的人群来预防充血性心力衰竭（CHF）恶化，检查其使用优化心室功能的药物，通过不同疾病阶段跟踪体重变化，以及 检索治疗强化所需的生命体征和实验室数据。

    Polymer Scaffold Degradation Control Via Chemical Control
    49.
    发明申请
    Polymer Scaffold Degradation Control Via Chemical Control 审中-公开
    通过化学控制的聚合物支架降解控制

    公开(公告)号：US20160152766A1

    公开(公告)日：2016-06-02

    申请号：US14956521

    申请日：2015-12-02

    Applicant: Elizabeth L Dirk ,  Shawn Dirk ,  Kirsten Cicotte

    Inventor： Elizabeth L Dirk ,  Shawn Dirk ,  Kirsten Cicotte

    IPC: C08G63/52

    CPC classification number: C08G63/52 ,  C08F222/10

    Abstract: A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.

    Abstract translation: 描述适合用作生物相容性构建体的多种聚合物和共聚物，以及作为非限制性具体实例的可降解组织支架的形成以及用于合成这些聚合物和共聚物的方法。 聚合物和共聚物的降解速率明显快于适用于相同用途的前述聚合物的降解速率。 还描述了具有能够通过选择所得共聚物中单体的特定化学计量来微调降解速率的合成途径的共聚物。 本公开还提供了一种用于马来酰氯的新型合成路线，其产生适用于本文所述共聚物合成方法的单体。

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