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公开(公告)号：US20110091454A1
公开(公告)日：2011-04-21
申请号：US12701651
申请日：2010-02-08
申请人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad S. Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad S. Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , A61P35/00
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
摘要翻译： 提供多肽序列和多核苷酸序列。 还提供了关于这些序列的这些序列和用途的注释信息。
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公开(公告)号：US20100322938A1
公开(公告)日：2010-12-23
申请号：US12863864
申请日：2009-01-22
申请人： Yossef Kliger , Ofer Levy , Itamar Borukhov , Assaf Wool , Ehud Schreiber , Anat Amir , Zurit Levine , Zohar Tiran , Anat Oren , Amir Toporik
发明人： Yossef Kliger , Ofer Levy , Itamar Borukhov , Assaf Wool , Ehud Schreiber , Anat Amir , Zurit Levine , Zohar Tiran , Anat Oren , Amir Toporik
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C07H21/04 , A61P25/28
CPC分类号： C07K14/775 , A61K38/00
摘要： Clusterin-derived peptides or homologues or derivatives thereof, pharmaceutical compositions including the same, methods of manufacturing the peptides, homologues, derivatives thereof and compositions including the same, and methods of treating conditions including administering the peptides, homologues, derivatives thereof and compositions including the same, are provided. Also provided are nucleotide sequences encoding the peptides, homologues, derivatives thereof and compositions including the same, antibodies directed to epitopes thereof and fusion proteins including the same
摘要翻译： 来自Clusterin的肽或其同系物或衍生物，包含其的药物组合物，制备肽的方法，同系物，其衍生物和包含其的组合物，以及治疗包括给予所述肽，同系物，衍生物和包括 相同，被提供。 还提供了编码肽，同系物，其衍生物和包含其的组合物的核苷酸序列，针对其表位的抗体和包含其的融合蛋白
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43.发明申请Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Cardiac Disease 审中-公开新型核苷酸和氨基酸序列及其用于诊断心脏病的测定及方法公开(公告)号：US20100248270A1
公开(公告)日：2010-09-30
申请号：US12623957
申请日：2009-11-23
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
CPC分类号： C07K14/705 , C07H21/04 , C07K16/18 , C07K2317/34 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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44.发明授权公开(公告)号：US07758862B2
公开(公告)日：2010-07-20
申请号：US12088210
申请日：2006-10-03
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/20 , C07K2319/30
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
摘要翻译： 提供了作为c-Met的剪接变体，肝细胞生长因子的受体和编码其的多核苷酸的新型多肽。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。
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45.发明申请Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Lung Cancer 审中-公开新型核苷酸和氨基酸序列及其用于肺癌诊断的方法及方法公开(公告)号：US20100068736A1
公开(公告)日：2010-03-18
申请号：US12557253
申请日：2009-09-10
申请人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad S. Cojocaru , Michal Ayalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
发明人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad S. Cojocaru , Michal Ayalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
IPC分类号： G01N33/53 , C07K2/00 , C07K16/00 , G01N33/574
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。
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公开(公告)号：US07678769B2
公开(公告)日：2010-03-16
申请号：US11781905
申请日：2007-07-23
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
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47.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer 失效核苷酸和氨基酸序列，以及其用于诊断肺癌的测定和方法公开(公告)号：US07667001B1
公开(公告)日：2010-02-23
申请号：US11978554
申请日：2007-10-30
申请人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad S. Cojocaru , Michal Avalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
发明人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad S. Cojocaru , Michal Avalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
IPC分类号： C07K16/00
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。
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公开(公告)号：US20080182299A1
公开(公告)日：2008-07-31
申请号：US11978204
申请日：2007-10-29
申请人： Gad S. Colocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
发明人： Gad S. Colocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
CPC分类号： G01N33/74 , C07K14/58 , G01N2800/324 , G01N2800/325 , Y10T436/143333
摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.
摘要翻译： 新型BNP变体。 根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。
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49.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 有权核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法公开(公告)号：US07345142B2
公开(公告)日：2008-03-18
申请号：US11043824
申请日：2005-01-27
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
IPC分类号： A61K38/00
CPC分类号： G01N33/6893 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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50.发明申请Novel thrombospondin-1 polynucleotides encoding variant thrombospondin-1 polypeptides and methods using same 审中-公开编码变体血小板反应蛋白-1多肽的新型血小板反应蛋白-1多核苷酸及其使用方法公开(公告)号：US20070219125A1
公开(公告)日：2007-09-20
申请号：US11709841
申请日：2007-02-23
申请人： Gad Cojocaru , Zurit Levine , Michal Ayalon-Soffer , Amir Toporik , Sarah Pollock , Galit Rotman , Merav Beiman
发明人： Gad Cojocaru , Zurit Levine , Michal Ayalon-Soffer , Amir Toporik , Sarah Pollock , Galit Rotman , Merav Beiman
IPC分类号： A61K38/36 , C07H21/04 , C07K14/745 , C07K16/36 , C12N5/10
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and phamaceutical compositions which can be used to treat various disorders such as cancer and retinopathies, using the polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于治疗各种疾病如癌症和视网膜病变的方法和药物组合物，使用本发明的多肽和多核苷酸。
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