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1.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 失效核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法公开(公告)号：US07714100B2
公开(公告)日：2010-05-11
申请号：US11978203
申请日：2007-10-29
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
IPC分类号： A61K38/00
CPC分类号： C07K14/705 , C07H21/04 , C07K16/18 , C07K2317/34 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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2.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 失效新型核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法公开(公告)号：US20080193941A1
公开(公告)日：2008-08-14
申请号：US11978203
申请日：2007-10-29
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Avalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Avalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
CPC分类号： C07K14/705 , C07H21/04 , C07K16/18 , C07K2317/34 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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公开(公告)号：US20180321225A1
公开(公告)日：2018-11-08
申请号：US15967719
申请日：2018-05-01
申请人： Mohamed Zayed , Clay Semenkovich
发明人： Mohamed Zayed , Clay Semenkovich
IPC分类号： G01N33/50 , G01N33/49 , G01N33/573
CPC分类号： G01N33/5091 , A61K31/444 , C12Y203/01085 , G01N33/492 , G01N33/573 , G01N2800/042 , G01N2800/324 , G01N2800/325 , G01N2800/326 , G01N2800/327 , G01N2800/328 , G01N2800/52 , G01N2800/56
摘要： Among the various aspects of the present disclosure is the provision of a method of detection, treatment, and monitoring of cardiovascular disease or a foot wound by detection of a novel biomarker, Fatty Acid Synthase (FAS).
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4.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 有权新型核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法公开(公告)号：US20060172311A1
公开(公告)日：2006-08-03
申请号：US11043824
申请日：2005-01-27
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
CPC分类号： G01N33/6893 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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5.发明申请Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Cardiac Disease 审中-公开新型核苷酸和氨基酸序列及其用于诊断心脏病的测定及方法公开(公告)号：US20100248270A1
公开(公告)日：2010-09-30
申请号：US12623957
申请日：2009-11-23
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
CPC分类号： C07K14/705 , C07H21/04 , C07K16/18 , C07K2317/34 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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6.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 有权核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法公开(公告)号：US07345142B2
公开(公告)日：2008-03-18
申请号：US11043824
申请日：2005-01-27
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
IPC分类号： A61K38/00
CPC分类号： G01N33/6893 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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