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    N-(5-((ARYL OR HETEROARYL)METHYLOXY)PENTYL)-SUBSTITUTED IMINOSUGARS AS INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE
    43.
    发明申请
    N-(5-((ARYL OR HETEROARYL)METHYLOXY)PENTYL)-SUBSTITUTED IMINOSUGARS AS INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE 审中-公开

    公开(公告)号：US20170226058A1

    公开(公告)日：2017-08-10

    申请号：US15129815

    申请日：2015-03-23

    Applicant: ACADEMISCH MEDISCH CENTRUM ,  UNIVERSITEIT LEIDEN

    Inventor： Herman Steven OVERKLEEFT ,  Stan VAN BOECKEL ,  Johannes Maria Franciscus Gerardus AERTS ,  Amar GHISAIDOOBE ,  Richard VAN DEN BERG

    IPC: C07D211/40

    CPC classification number: C07D211/40 ,  A61P3/00 ,  C07D211/46

    Abstract: Deoxynojirimycin and deoxygalactonojirimycin derivatives according to the present invention are N-alkylated D-galacto, D-gluco- or L-ido-deoxynojirimycin with a linear methyloxypentyl group bearing various sidegroups and a non-fused bicyclic aromatic group (“X”) on the methyloxy-carbon. These compounds display an increased inhibitory potency towards GCS, and/or an increased inhibitory potency towards GBA2, and/or a decreased inhibitory potency towards GBA1, relative to known deoxynojirimycin derivatives of the same (D-gluco, L-ido or D-galacto) configuration. Therefore, compounds of the present invention are effective in the treatment of diseases which are associated with an irregular level of cytosolic or lysosomal glucosylceramide and/or higher glycosphingolipids, such as a lysosomal storage disorder, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Sandhoff disease, GM1 gangliosidosis, Sialidosis, Niemann Pick disease type C and AMRF, or a symptom of one of the diseases collectively classed as metabolic syndrome, such as obesity, insulin resistance, hyperlipidemia, hypercholesterolemia, polycystic kidney disease, type II diabetes and chronic inflammation, or a neurodenegerative disorder, such as Parkinson disease or Lewy-body dementia.

    METHOD AND DEVICE FOR RECEIVING A DROPLET
    45.
    发明申请
    METHOD AND DEVICE FOR RECEIVING A DROPLET 有权
    用于接收滴液的方法和装置

    公开(公告)号：US20160139090A1

    公开(公告)日：2016-05-19

    申请号：US14898833

    申请日：2014-06-19

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Jan-Williem SCHOONEN ,  Peter LINDENBURG ,  Paul VULTO ,  Thomas HANKEMEIER

    IPC: G01N30/12 ,  G01N30/72 ,  G01N30/06 ,  G01N30/64

    CPC classification number: G01N30/12 ,  G01N1/28 ,  G01N1/34 ,  G01N1/4022 ,  G01N30/06 ,  G01N30/463 ,  G01N30/64 ,  G01N30/7233

    Abstract: The present invention relates to a droplet receiver, comprising a receptacle for receiving a droplet, a fluid conduit connected at a first end thereof to the droplet receptacle thereby providing a course within which the droplet received in the droplet receptacle moves, the conduit at its distal end in communication with a reservoir,and a fluid layer wetting the internal walls of the receptacle and conduit in such a way as permit reception of the droplet without loss of the received droplet due to wetting of the internal receptacle and conduit walls.

    Abstract translation: 本发明涉及一种液滴接收器，包括用于接收液滴的容器，在其第一端处连接到液滴容器的流体导管，从而提供容纳在液滴容器中的液滴移动的过程，其远端处的导管 与储存器连通，并且液体层以允许接收液滴而不会由于内部容器和导管壁的润湿而损失所接收的液滴的方式润湿容器和导管的内壁。

    THIN FILM FORMATION
    46.
    发明申请
    THIN FILM FORMATION 审中-公开
    薄膜形成

    公开(公告)号：US20150017344A1

    公开(公告)日：2015-01-15

    申请号：US14375699

    申请日：2013-01-29

    Applicant: Universiteit Leiden

    Inventor： Guocai Dong ,  Richard Van Rijn

    IPC: C23C16/46 ,  C23C16/455 ,  C23C16/56 ,  C23C16/26 ,  C23C16/02

    CPC classification number: C23C16/463 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/184 ,  C01B32/186 ,  C23C16/0227 ,  C23C16/26 ,  C23C16/45519 ,  C23C16/45557 ,  C23C16/56

    Abstract: A method of forming a graphene film (20) on one or more surfaces (10) of a copper-containing substrate (12) comprising the steps of: (i) heating a copper-containing substrate (12) defining one or more surfaces (10) to an exposure temperature; (ii) exposing the substrate (12) to a carbon-containing precursor gas at the exposure temperature for a predetermined period of time to dissolve carbon atoms into the substrate (12) and saturate the substrate (12) with carbon atoms; and (iii) cooling the substrate (12) so as to segregate the dissolved carbon atoms (16) from the substrate (12) to form a graphene film (20) on the or each surface (10) of the substrate (12); wherein the method further includes the step of selecting the copper-containing substrate (12) on the basis of its thickness to control the depth of the graphene film (20) formed on the or each surface (10) of the substrate (12) on cooling the substrate (12) so as to segregate the dissolved carbon atoms from the substrate (12).

    Abstract translation: 一种在含铜衬底（12）的一个或多个表面（10）上形成石墨烯膜（20）的方法，包括以下步骤：（i）加热限定一个或多个表面的含铜衬底（12） 10）暴露温度; （ii）在暴露温度下将基板（12）暴露于含碳前体气体预定时间段以将碳原子溶解到基底（12）中并用碳原子使基底（12）饱和; 和（iii）冷却所述衬底（12）以便将所述溶解的碳原子（16）与所述衬底（12）分离，以在所述衬底（12）的所述表面（10）上形成石墨烯膜（20）。 其中所述方法还包括基于其厚度来选择含铜衬底（12）的步骤，以控制形成在衬底（12）的每个表面（10）上的石墨烯膜（20）的深度 冷却所述基板（12）以使所述溶解的碳原子与所述基板（12）分离。

    C2,5'-disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and pharmaceutical compositions containing them
    47.
    发明申请
    C2,5'-disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and pharmaceutical compositions containing them 失效
    C2,5'-二取代的和N6，C2,5'-三取代的腺苷衍生物和含有它们的药物组合物

    公开(公告)号：US20040127452A1

    公开(公告)日：2004-07-01

    申请号：US10653464

    申请日：2003-09-03

    Applicant: UNIVERSITEIT LEIDEN ,  CAN-FITE BIOPHARMA LTD.

    Inventor： Erica Van Tilburg ,  Ad Ijzerman

    IPC: A61K031/7076 ,  C07H019/16

    CPC classification number: C07H19/16

    Abstract: The present invention concerns novel C2,5null-disubstituted and N6,C2,5null-trisubstituted adenosine derivatives and their different uses. These adenosine derivatives were found to be potent adenosine receptor agonists and thus are of a therapeutic value in the treatment and prophylaxis of diseases and disorders affected by adenosine receptor agonists.

    Abstract translation: 本发明涉及新的C2,5'-二取代和N6，C2,5'-三取代的腺苷衍生物及其不同用途。 发现这些腺苷衍生物是有效的腺苷受体激动剂，因此在治疗和预防受腺苷受体激动剂影响的疾病和病症方面具有治疗价值。

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