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    Antimicrobial compounds
    35.
    发明授权
    Antimicrobial compounds 失效
    抗菌化合物

    公开(公告)号：US07385086B2

    公开(公告)日：2008-06-10

    申请号：US10764451

    申请日：2004-01-27

    申请人： Craig A. Townsend ,  James D. Dick ,  Gary R. Pasternack ,  Francis P. Kuhajda ,  Nicole M. Parrish

    发明人： Craig A. Townsend ,  James D. Dick ,  Gary R. Pasternack ,  Francis P. Kuhajda ,  Nicole M. Parrish

    IPC分类号： C07C317/00 ,  C07C317/02 ,  C07C317/04 ,  C07C317/06 ,  C07C317/08

    CPC分类号： C40B40/04 ,  C07C311/06 ,  C07C317/44

    摘要： This invention provides compounds and methods for treating, with said compound, a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SOn-Z-CO—Y, where R is an alkyl groups having 6-20 carbon atoms, unsaturated hydrocarbon groups having 6-20 carbon atoms, or alkyl groups having 6-20 carbon atoms interrupted by at least one aromatic ring; Z is —CH2—, —CH2CH2—, —NH—NH—, —O—, ——NH—, —O—NH—, —CH2—NH—, —CH2—O—, —NH—O—, —NH—CH2—, —O—CH2—, and —CH═CH—; Y is —NH2, —O—CH2—C6H5, —CO—CO—O—CH3, and —O—CH3; and n is 1 or 2. It has been discovered that these compounds treat microbially-based infections caused by corynebacteria, nocardiae, rhodococcus, and mycobacteria. These compounds may be used to treat mycobacterial cells, such as Mycobacteria tuberculosis, drug resistant M. tuberculosis, M. avium intracellulare, M. leprae, M. paratuberculosis, and pathogenic Mycobacteria sp.

    摘要翻译： 本发明提供了通过向动物施用含有具有式R-SO n -Z-CO-Y的化合物的药物组合物，通过向所述化合物处理分枝杆菌感染的化合物和方法，其中R 是具有6-20个碳原子的烷基，具有6-20个碳原子的不饱和烃基或具有6-20个碳原子的烷基被至少一个芳环中断; Z是-CH 2 - ， - CH 2 CH 2 - ， - NH-NH-， - O - ， - NH-， -O-NH-，-CH 2 -NH-，-CH 2 -O-，-NH-O-，-NH-CH 2， -O - CH 2 - 和-CH-CH-; Y是-NH 2，-O-CH 2 -C 6 H 5，-CO-CO- O-CH 3，和-O-CH 3; 已发现这些化合物治疗由棒状杆菌，诺卡氏菌，罗红球菌和分枝杆菌引起的基于微生物的感染。 这些化合物可用于治疗分枝杆菌细胞，例如结核分枝杆菌，耐药性结核分枝杆菌，胞内分枝杆菌，麻疯病，副结核分枝杆菌和致病性分枝杆菌属。