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    SILICONE POLYOXAMIDE AND SILICONE POLYOXAMIDE-HYDRAZIDE COPOLYMERS
    31.
    发明申请
    SILICONE POLYOXAMIDE AND SILICONE POLYOXAMIDE-HYDRAZIDE COPOLYMERS 有权
    硅氧烷聚酰胺和硅氧烷聚酰胺 - 氢化物共聚物

    公开(公告)号：US20110071270A1

    公开(公告)日：2011-03-24

    申请号：US12563311

    申请日：2009-09-21

    申请人： David S. HAYS ,  Richard G. HANSEN ,  Stephen A. JOHNSON ,  Benjamin J. BENDING ,  Kyle J. LINDSTROM

    发明人： David S. HAYS ,  Richard G. HANSEN ,  Stephen A. JOHNSON ,  Benjamin J. BENDING ,  Kyle J. LINDSTROM

    IPC分类号： C08G77/04 ,  C07C291/02

    CPC分类号： C07C251/66 ,  C08G77/455

    摘要： Silicone polyoxamide and silicone polyoxamide-hydrazide copolymers comprise at least two repeating units of formula I In this formula, each R1 is independently an alkyl, haloalkyl, aralkyl, alkenyl, aryl, or aryl substituted with an alkyl, alkoxy, or halo; each Y is independently an alkylene, aralkylene, or a combination thereof; each G is independently a bond or a divalent residue equal to a diamine of formula R3HN-G-NHR3 minus the two —NHR3 groups; each R3 is independently hydrogen or alkyl or R3 taken together with G and with the nitrogen to which they are both attached form a heterocyclic group; each n is independently an integer of 0 to 1500; each p is independently an integer of 1 to 10, and the average of p is 1.2 or greater; and each q is independently an integer of 1 or greater, and every q is not the same integer.

    摘要翻译： 硅氧烷聚酰胺和硅氧烷聚酰胺 - 酰肼共聚物包含至少两个式I的重复单元。在该式中，每个R 1独立地为烷基，卤代烷基，芳烷基，烯基，芳基或被烷基，烷氧基或卤素取代的芳基; 每个Y独立地是亚烷基，亚芳基或其组合; 每个G独立地是等于式R3HN-G-NHR3的二胺减去两个-NHR 3基团的键或二价残基; 每个R 3独立地为氢或烷基或R 3与G一起并与它们所连接的氮形成杂环基; 每个n独立地为0至1500的整数; 每个p独立地为1〜10的整数，p的平均值为1.2以上; 并且每个q独立地为1或更大的整数，并且每个q不是相同的整数。

    Process for the synthesis for alkoxy amines and their use in controlled radical polymerization
    34.
    发明申请
    Process for the synthesis for alkoxy amines and their use in controlled radical polymerization 审中-公开
    烷基胺合成方法及其在受控自由基聚合中的应用

    公开(公告)号：US20040002606A1

    公开(公告)日：2004-01-01

    申请号：US10464999

    申请日：2003-06-19

    发明人： Christophe Detrembleur ,  Thomas Grob ,  Rolf-Volker Meyer

    IPC分类号： C07D211/40 ,  C07C409/24 ,  C07C291/02

    CPC分类号： C07D295/24 ,  C07D211/94 ,  C08F4/00

    摘要： A one-pot process for the preparation of alkoxyamines conforming to formulae (I) or (II), preferably (I) 1 is disclosed. The process entails (1) reacting of an oxidizing agent (A) with a sterically hindered secondary amine of the general formula (III), 2 in a water-containing medium to form a reaction product and an aqueous phase, (2) removing of the aqueous phase, and (3) (adding to the reaction product a free-radical initiator (B) under conditions that promote the decomposition of the initiator to generate free radicals. Also disclosed is a process for polymerizing monomers, the process using the alkoxyamine prepared by the inventive process.

    摘要翻译： 公开了一种用于制备符合式（I）或（II），优选（I）的烷氧基​​胺的一锅法。 该方法需要（1）将氧化剂（A）与通式（III）的空间位阻仲胺反应在含水介质中以形成反应产物和水相，（2）除去 水相，和（3）（在促进引发剂分解以产生自由基的条件下向反应产物中加入自由基引发剂（B）。还公开了使单体聚合的方法，使用制备的烷氧基胺 通过本发明的方法。

    Production of solid tertiary amine oxides
    36.
    发明授权
    Production of solid tertiary amine oxides 失效
    固体叔胺氧化物的生产

    公开(公告)号：US6121490A

    公开(公告)日：2000-09-19

    申请号：US291164

    申请日：1999-04-14

    申请人： Hassan Y. Elnagar

    发明人： Hassan Y. Elnagar

    IPC分类号： C07C291/02 ,  C07C292/02

    CPC分类号： C07C291/02

    摘要： A process for producing tertiary amine oxide having two methyl or ethyl groups and one long chain primary aliphatic group in a stable, solid form is described. Aqueous 65-90% hydrogen peroxide and tertiary amine having two methyl or ethyl groups and one primary aliphatic hydrocarbyl group of 8-24 carbon atoms are mixed in proportions of ca. 1.1-1.3 moles of hydrogen peroxide per mole of tertiary amine in the presence of carbon dioxide and in the absence of organic solvent. When the conversion of the tertiary amine to tertiary amine oxide in the reaction mass has reached ca. 60-90%, the reaction mass is transferred to a separate vessel and the reaction mass is then allowed to solidify at a temperature of ca. 20-60.degree. C. The process makes possible the production of highly pure solid product without formation of any appreciable amounts of undesirable by-products. Also, the process is environmentally friendly, and the problems and expense associated with product workup, purification, crystallization, and waste product disposal are largely, if not entirely, avoided. Moreover, the solid storage stable products can be stored and shipped at significantly reduced costs as compared to liquid solutions. The products are useful in the manufacture of household and commercial laundry detergent formulations furnished in the form of powders or flakes.

    摘要翻译： 描述了具有稳定，固体形式的具有两个甲基或乙基和一个长链伯脂族基团的叔胺氧化物的方法。 具有两个甲基或乙基和一个8-24个碳原子的一个脂肪族脂族烃基的65-90％过氧化氢水溶液和叔胺以约 在二氧化碳存在下，在不存在有机溶剂的情况下，每摩尔叔胺使用1.1-1.3摩尔过氧化氢。 当反应物质中叔胺转化为叔胺氧化物达到约 60-90％，将反应物质转移到单独的容器中，然后使反应物质在约5℃的温度下固化。 20-60℃。该方法使得可以生产高纯度固体产品而不形成任何可观量的不合需要的副产物。 此外，该方法是环境友好的，与产品后处理，净化，结晶和废物处理相关的问题和费用在很大程度上（如果不是完全避免）。 此外，与液体溶液相比，可以以显着降低的成本储存和运输固体储存稳定的产品。 该产品可用于制造以粉末或薄片形式提供的家用和商业洗衣洗涤剂制剂。

    Spin trap nitronyl hindered phenols
    37.
    再颁专利
    Spin trap nitronyl hindered phenols 失效
    自旋阱硝基受阻酚

    公开(公告)号：USRE36594E

    公开(公告)日：2000-02-29

    申请号：US942494

    申请日：1997-10-02

    申请人： Edward G. Janzen ,  Allan L. Wilcox

    发明人： Edward G. Janzen ,  Allan L. Wilcox

    IPC分类号： A61K31/135 ,  C07C291/02 ,  C07C251/00 ,  A61K31/15 ,  C07C251/32

    CPC分类号： C07C291/02 ,  A61K31/135

    摘要： The invention is the use of nitronyl substituted hindered phenols as antioxidants in therapeutic applications. In the preferred embodiment the compositions have the general formula: ##STR1## Wherein R1 is hydrogen, an alkyl or an aryl and R2 is an alkyl or an aryl; R.sub.3 is an alkyl; and R.sub.4 is an alkyl. Further, the invention relates to novel compositions useful as antioxidants. The novel compounds include: 2,6-di-tert-butyl-4-(N-tert-octyl)nitronyl phenol (DBONP); 2,6-dimethyl-4-(N-tert-octyl)nitronyl phenol (DMONP); N-tert-octyl-C-phenyl nitrone (OPN).

    摘要翻译： 本发明是在治疗应用中使用硝基取代的受阻酚作为抗氧化剂。 在优选的实施方案中，组合物具有以下通式：其中R1是氢，烷基或芳基，R2是烷基或芳基; R3是烷基; R4是烷基。 此外，本发明涉及可用作抗氧化剂的新型组合物。 新型化合物包括：2,6-二叔丁基-4-（N-叔辛基）硝基苯酚（DBONP）; 2,6-二甲基-4-（N-叔辛基）硝基苯酚（DMONP）; N-叔辛基-C-苯基硝酮（OPN）。

    Spin trapping pharmaceutical compositions and methods for use thereof
    38.
    发明授权
    Spin trapping pharmaceutical compositions and methods for use thereof 失效
    旋转捕获药物组合物及其使用方法

    公开(公告)号：US6002001A

    公开(公告)日：1999-12-14

    申请号：US969344

    申请日：1997-11-28

    申请人： John M. Carney ,  Robert A. Floyd

    发明人： John M. Carney ,  Robert A. Floyd

    IPC分类号： A61K31/135 ,  A61K31/15 ,  A61K31/167 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  C07C291/02 ,  C07D279/10

    CPC分类号： A61K31/135 ,  A61K31/15 ,  A61K31/167 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  C07C291/02

    摘要： Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrroline N-oxide, (DMPO), .alpha.-(4-pyridyl-1-oxide)-N-tert-butylnitrone, (POBN), and (TEMPO) spin-trapping derivatives thereof. Examples of derivatives of PBN include halogenated derivatives, bifunctional derivatives, conjugates with drugs or targeting molecules, dimers and cyclodextran polymers of PBN. Many different disorders can be treated using these compounds, including diseases or disorders of the central and peripheral nervous systems, and disorders arising from ischemia, infection, inflammation, oxidation from exposure to radiation or cytotoxic compounds, as well as due to naturally occurring processes such as aging.

    摘要翻译： 现在已经发现旋转捕获组合物现在已被发现有效地治疗各种疾病，包括诸如由局部缺血，感染，炎症，暴露于辐射或细胞毒性化合物引起的疾病，不仅仅是中枢和周围神经系统，而是 外周器官疾病具有多种病因。 在优选的实施方案中，用于治疗缺血组织损伤的组合物在用于静脉内，口服，局部或鼻/肺部施用的合适的药物载体中含有PBN或其活性衍生物。 其他优选的自旋捕获剂包括5,5-二甲基吡咯啉N-氧化物（DMPO），α-（4-吡啶基-1-氧化物）-N-叔丁基硝酮，（POBN）和（TEMPO）自旋捕获 衍生物。 PBN衍生物的实例包括卤代衍生物，双官能衍生物，与药物或靶向分子的缀合物，二聚体和PBN的环糊精聚合物。 可以使用这些化合物治疗许多不同的病症，包括中枢和周围神经系统的疾病或病症，以及由缺血，感染，炎症，暴露于辐射或细胞毒性化合物的氧化引起的疾病，以及由于天然存在的过程 作为老化。

    Compositions stabilized with tertiary amine oxides
    39.
    发明授权
    Compositions stabilized with tertiary amine oxides 失效
    用叔胺氧化物稳定的组合物

    公开(公告)号：US5922794A

    公开(公告)日：1999-07-13

    申请号：US824675

    申请日：1997-03-26

    申请人： Vaikunth S. Prabhu ,  Roger W. Avakian

    发明人： Vaikunth S. Prabhu ,  Roger W. Avakian

    IPC分类号： C07C291/02 ,  C08K5/00 ,  C08K5/098 ,  C08K5/10 ,  C08K5/13 ,  C08K5/16 ,  C08K5/32 ,  C08K5/36 ,  C08K5/49 ,  C08L23/00 ,  C08L101/00 ,  C08K5/17

    CPC分类号： C08K5/32 ,  C08K5/005

    摘要： Thermoplastic resin composition are provided that comprise a thermoplastic resin or mixture thereof, a stabilizing amount of a stabilizer or mixture of stabilizers selected from the group consisting of the phenolic antioxidants, the 3-arylbenzofuranones, the hindered amine stabilizers, the ultraviolet light absorbers, the organic phosphorus compounds, the alkaline metal salts of fatty acids, the hydroxylamines, and the thiosynergists, and a stabilizing amount of a tertiary amine oxide. The compositions have improved stability against discoloration upon exposure to heating or to the combustion products of natural gas by the concomitant presence of an effective amount of a tertiary amine oxide.

    摘要翻译： 提供热塑性树脂组合物，其包含热塑性树脂或其混合物，稳定剂量的稳定剂或稳定剂混合物，其选自酚类抗氧化剂，3-芳基苯并呋喃酮，受阻胺稳定剂，紫外光吸收剂， 有机磷化合物，脂肪酸的碱金属盐，羟胺和硫代增效剂，以及稳定量的叔胺氧化物。 通过伴随有效量的叔胺氧化物的存在，组合物在暴露于加热或天然气的燃烧产物时具有改善的抗变色稳定性。