公开(公告)号：US20070238735A1

公开(公告)日：2007-10-11

申请号：US11802161

申请日：2007-05-21

申请人： David Garvey ,  Subhash Khanapure ,  Ramani Ranatunge ,  Stewart Richardson ,  Joseph Schroeder

发明人： David Garvey ,  Subhash Khanapure ,  Ramani Ranatunge ,  Stewart Richardson ,  Joseph Schroeder

IPC分类号： A61K31/495 ,  A61K31/415 ,  C07D213/00 ,  C07D241/10

CPC分类号： C07D213/55 ,  C07D213/50 ,  C07D231/12 ,  C07D231/14

摘要： The invention provides novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions and kits comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

摘要翻译： 本发明提供新型环氧合酶2（COX-2）选择性抑制剂和包含至少一种环加氧酶2（COX-2）选择性抑制剂的新型组合物和试剂盒，以及任选地，至少一种捐赠，转移或释放一氧化氮的化合物， 内源性合成一氧化氮，提高内源性内源性松弛因子水平，或是一氧化氮合成酶的底物和/或至少一种治疗剂。 本发明的新型环加氧酶2选择性抑制剂可以任选地亚硝化和/或亚硝化。 本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗和/或改善COX-2选择性抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾和/或呼吸毒性; 用于治疗和/或预防由环氧合酶-2水平升高引起的其他疾病; 并用于改善COX-2选择性抑制剂的心血管外形。

公开(公告)号：US20070155734A1

公开(公告)日：2007-07-05

申请号：US11705773

申请日：2007-02-14

申请人： Ramani Ranatunge ,  David Garvey ,  Stewart Richardson

发明人： Ramani Ranatunge ,  David Garvey ,  Stewart Richardson

IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/655 ,  A61K31/55 ,  A61K31/454 ,  A61K31/4196 ,  A61K31/4192 ,  A61K31/4164 ,  A61K31/415

CPC分类号： C07D231/12

摘要： The invention provides novel cyclooxygenase 2 (COX-2) selective inhibitors having at least one oxime group or hydrazone group and novel compositions and kits comprising at least one COX-2 selective inhibitor having at least one oxime group or hydrazone group, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention having at least one oxime group or hydrazone group can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

摘要翻译： 本发明提供具有至少一个肟基或腙基团的新型环加氧酶2（COX-2）选择性抑制剂，以及包含至少一种具有至少一个肟基或腙基团的COX-2选择性抑制剂的新组合物和试剂盒，任选地亚硝化和/ 或亚硝酰化，和任选地至少一种一氧化氮供体，和/或任选的至少一种治疗剂。 具有至少一个肟基或腙基团的本发明的新型环加氧酶2选择性抑制剂可任选被亚硝化和/或亚硝化。 本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗和/或改善COX-2选择性抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾和/或呼吸毒性; 用于治疗和/或预防由环氧合酶-2水平升高引起的其他疾病; 并用于改善COX-2选择性抑制剂的心血管外形。

公开(公告)号：US20060194861A1

公开(公告)日：2006-08-31

申请号：US11418187

申请日：2006-05-05

申请人： Ipul Bandarage ,  Richard Earl ,  Maiko Ezawa ,  Xinqin Fang ,  David Garvey ,  Subhash Khanapure ,  Ramani Ranatunge ,  Stewart Richardson ,  Joseph Schroeder ,  Cheri Stevenson ,  Shiow-Jyi Wey

发明人： Ipul Bandarage ,  Richard Earl ,  Maiko Ezawa ,  Xinqin Fang ,  David Garvey ,  Subhash Khanapure ,  Ramani Ranatunge ,  Stewart Richardson ,  Joseph Schroeder ,  Cheri Stevenson ,  Shiow-Jyi Wey

IPC分类号： C07D231/06 ,  A61K31/415

CPC分类号： C07D231/12 ,  C07D261/08 ,  C07D401/04

摘要： The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

摘要翻译： 本发明描述了新型环氧合酶2（COX-2）选择性抑制剂和包含至少一种环氧合酶2（COX-2）选择性抑制剂的新型组合物，以及任选地至少一种捐赠，转移或释放一氧化氮的化合物，刺激内源性合成 的一氧化氮，提高内源性内源性释放因子水平，或者是一氧化氮合酶的底物和/或至少一种治疗剂。 本发明还提供了包含至少一种COX-2选择性抑制剂，任选地亚硝基化和/或亚硝基化的新的试剂盒，以及任选的至少一种一氧化氮供体，和/或任选的至少一种治疗剂。 本发明的新型环加氧酶2选择性抑制剂可以任选地亚硝化和/或亚硝化。 本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗和/或改善COX-2选择性抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾和/或呼吸毒性; 用于治疗和/或预防由环氧合酶-2水平升高引起的其他疾病; 并用于改善COX-2选择性抑制剂的心血管外形。

公开(公告)号：US20060009431A1

公开(公告)日：2006-01-12

申请号：US11221901

申请日：2005-09-09

申请人： Richard Earl ,  David Garvey ,  Ricky Gaston ,  Chia-En Lin ,  Ramani Ranatunge ,  Stewart Richardson ,  Cheri Stevenson

发明人： Richard Earl ,  David Garvey ,  Ricky Gaston ,  Chia-En Lin ,  Ramani Ranatunge ,  Stewart Richardson ,  Cheri Stevenson

IPC分类号： A61K31/56 ,  A61K31/21

CPC分类号： C07J17/00 ,  C07J1/00 ,  C07J31/006 ,  C07J41/0044 ,  C07J43/00 ,  C07J43/003

摘要： The invention describes novel nitrosated and/or nitrosylated compounds of the invention, and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated compound of the invention, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one compound of the invention, that is optionally nitrosated and/or nitrosylated, and at least one nitric oxide donor compound and/or at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for treating cardiovascular diseases, for inhibiting platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device, for treating pathological conditions resulting from abnormal cell proliferation; transplantation rejections, autoimmune, inflammatory, proliferative, hyperproliferative or vascular diseases; for reducing scar tissue or for inhibiting wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis by administering at least one compound of the invention that is optionally nitrosated and/or nitrosylated, in combination with nitric oxide donors that are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions. The compounds of the invention are preferably estradiol compounds, troglitazone compounds, tranilast compounds, retinoic acid compounds, resveratol compounds, myophenolic acid compounds, acid compounds, anthracenone compounds and trapidil compounds.

摘要翻译： 本发明描述了本发明的新型亚硝化和/或亚硝基化化合物及其药学上可接受的盐，以及包含至少一种本发明的亚硝基化和/或亚硝化化合物和任选的至少一种一氧化氮供体化合物和/ 或至少一种治疗剂。 本发明还提供了包含至少一种本发明的化合物，其任选被亚硝化和/或亚硝基化的新化合物，以及至少一种一氧化氮供体化合物和/或至少一种治疗剂。 本发明的化合物和组合物也可以结合到基质上。 本发明还提供了治疗心血管疾病的方法，用于抑制由血液暴露于医疗器械引起的血小板聚集和血小板粘附，用于治疗由异常细胞增殖引起的病理状况; 移植排斥，自身免疫，炎症，增殖，过度增生或血管疾病; 用于减少瘢痕组织或抑制伤口收缩，特别是预防和/或治疗再狭窄的方法，通过给予至少一种任选地亚硝化和/或亚硝基化的本发明化合物与能够释放硝酸的一氧化氮供体组合 在生理条件下氧化或间接地将一氧化氮递送或转移到靶位点。 本发明的化合物优选为雌二醇化合物，曲格列酮化合物，曲尼司特化合物，视黄酸化合物，白藜芦醇化合物，肌醇酸化合物，酸化合物，蒽酮化合物和捕获剂化合物。

公开(公告)号：US08863621B2

公开(公告)日：2014-10-21

申请号：US13367305

申请日：2012-02-06

申请人： Allan Stewart Richardson

发明人： Allan Stewart Richardson

IPC分类号： B25B13/50 ,  E21B19/16

CPC分类号： E21B19/164

摘要： A power tong includes a rotor, driven by a primary drive, for spinning and torquing threaded connections of a tubular gripped in the rotor. A grip in the rotor grips the tubular. A serpentine member supplies power to actuate the grip. The serpentine member is driven by a secondary drive. The primary and secondary drives are mounted on a stator frame. The rotor is rotatably mounted to the stator frame and driven by the primary drive during continuous three hundred and sixty degrees of rotation. A fixed or backup jaw may also be mounted to the stator frame. Tubular grippers on the fixed jaw grip a first side of a tubular joint. The grip on the rotor grips the opposite side of the tubular joint. High torque low-rotational speed applied to the rotor torques the joint. Low torque high-rotational speed applied to the rotor spins the joint.

摘要翻译： 动力钳包括由主驱动器驱动的转子，用于旋转和扭转夹在转子中的管状物的螺纹连接。 转子中的把手握住管状物。 蛇形部件供电来驱动手柄。 蛇形构件由次驱动驱动。 主驱动器和次驱动器安装在定子架上。 转子可旋转地安装在定子架上，并在连续的360度旋转期间由主驱动器驱动。 固定或备用钳口也可以安装在定子框架上。 固定钳口上的管状夹持器夹紧管状接头的第一侧。 转子上的把手握住管状接头的相对侧。 施加到转子的高转矩低转速扭转接头。 施加在转子上的低转矩高转速旋转接头。

公开(公告)号：US20140283653A1

公开(公告)日：2014-09-25

申请号：US14296941

申请日：2014-06-05

申请人： Allan Stewart Richardson

发明人： Allan Stewart Richardson

IPC分类号： E21B19/16

CPC分类号： E21B19/164

摘要： A power tong includes a rotor, driven by a primary drive, for spinning and torquing threaded connections of a tubular gripped in the rotor. A grip in the rotor grips the tubular. A serpentine member supplies power to actuate the grip. The serpentine member is driven by a secondary drive. The primary and secondary drives are mounted on a stator frame. The rotor is rotatably mounted to the stator frame and driven by the primary drive during continuous three hundred and sixty degrees of rotation. A fixed or backup jaw may also be mounted to the stator frame. Tubular grippers on the fixed jaw grip a first side of a tubular joint. The grip on the rotor grips the opposite side of the tubular joint. High torque low-rotational speed applied to the rotor torques the joint. Low torque high-rotational speed applied to the rotor spins the joint.

摘要翻译： 动力钳包括由主驱动器驱动的转子，用于旋转和扭转夹在转子中的管状物的螺纹连接。 转子中的把手握住管状物。 蛇形部件供电来驱动手柄。 蛇形构件由次驱动驱动。 主驱动器和次驱动器安装在定子架上。 转子可旋转地安装在定子架上，并在连续的360度旋转期间由主驱动器驱动。 固定或备用钳口也可以安装在定子框架上。 固定钳口上的管状夹持器夹紧管状接头的第一侧。 转子上的把手握住管状接头的相对侧。 施加到转子的高转矩低转速扭转接头。 施加在转子上的低转矩高转速旋转接头。

公开(公告)号：US20120272792A1

公开(公告)日：2012-11-01

申请号：US13367305

申请日：2012-02-06

申请人： Allan Stewart Richardson

发明人： Allan Stewart Richardson

IPC分类号： E21B19/16

CPC分类号： E21B19/164

摘要： A power tong continuously rotates tubulars for spinning and torquing threaded connections. Continuous rotation is achieved through a rotating jaw having a grip that grips the tubular and continuously rotates with it. A serpentine supplies directly or indirectly power to actuate the grip. The serpentine is driven by a secondary drive mounted on a fixed frame. The rotating jaw is rotatably mounted to the fixed frame and driven during continuous three hundred and sixty degrees of rotation by a primary drive, mounted on the fixed frame. A fixed jaw may also be mounted to the frame. Tubular grippers on the fixed jaw grip a first side of a tubular joint. The grip on the rotating jaw grips the opposite second side of the tubular joint. High torque low-rotational speed applied to the rotating jaw torques the joint. Low torque high-rotational speed applied to the rotating jaw spins the joint.

摘要翻译： 动力钳连续旋转管子，用于旋转和扭转螺纹连接。 连续旋转是通过具有握持管的旋转夹爪实现的，并且与其一起旋转。 蛇纹石直接或间接地供电来驱动抓地力。 蛇形管由安装在固定框架上的辅助驱动器驱动。 旋转夹爪可旋转地安装在固定框架上，并通过安装在固定框架上的主驱动器连续转动360度。 固定夹爪也可以安装在框架上。 固定钳口上的管状夹持器夹紧管状接头的第一侧。 旋转钳口上的把手夹住管状接头的相对的第二侧。 施加到旋转夹爪的高转矩低转速扭转接头。 施加到旋转夹爪的低转矩高转速旋转接头。

公开(公告)号：US07566493B2

公开(公告)日：2009-07-28

申请号：US10257850

申请日：2001-04-20

申请人： Alexander Stewart Richardson ,  John Andrew Smyth

发明人： Alexander Stewart Richardson ,  John Andrew Smyth

IPC分类号： B32B5/16 ,  B32B27/00

CPC分类号： C09D7/69 ,  C08L1/02 ,  C09D7/65 ,  Y10T428/25 ,  Y10T428/253 ,  Y10T428/27 ,  Y10T428/273 ,  Y10T428/277 ,  Y10T428/2982 ,  Y10T428/31971 ,  Y10T428/31993

摘要： The invention relates to a coating composition comprising (i) a supporting medium, and (ii) a plurality of cellulose particles, having an average dry particle size of less than 10 μm, dispersed in the supporting medium, excluding aqueous coating compositions adapted for application to paper. The invention also relates to a coating composition comprising (i) a supporting medium, and (ii) a plurality of cellulose particles, having an average dry particle size of less than 10 μm, dispersed in the supporting medium in an amount of less than about 5 g/L. The coating compositions of the invention form coatings which have useful thermal properties.

摘要翻译： 本发明涉及一种涂料组合物，其包含（i）支撑介质和（ii）分散在支持介质中的平均干燥颗粒尺寸小于10um的多个纤维素颗粒，不包括适于施用的水性涂料组合物 到纸上 本发明还涉及一种涂料组合物，其包含（i）支撑介质和（ii）分散在载体介质中的少于约10μm的平均干燥颗粒尺寸小于10μm的多个纤维素颗粒 5 g / L。 本发明的涂料组合物形成具有有用的热性质的涂料。

公开(公告)号：US20070155781A1

公开(公告)日：2007-07-05

申请号：US11604677

申请日：2006-11-28

申请人： David Garvey ,  L. Letts ,  H. Renfroe ,  Stewart Richardson

发明人： David Garvey ,  L. Letts ,  H. Renfroe ,  Stewart Richardson

IPC分类号： A61K31/46 ,  C07D451/02

CPC分类号： C07D451/06 ,  C07C313/36 ,  C07D311/22 ,  C07D451/10 ,  C07D471/04 ,  C07J5/00 ,  C07J7/00 ,  C07J31/00 ,  C07J71/00 ,  C07J71/0031

摘要： Disclosed are (i) compounds of a steroid, a β-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production of NO or EDRF in vivo; (ii) compositions of steroids, β-agonists, anticholinergics, mast cell stabilizers and PDE inhibitors, which can optionally be substituted with at least one NO or NO2 moiety or a group which stimulates endogenous production of NO or EDRF in vivo, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO+) or nitroxyl (NO−), or as the neutral species, nitric oxide (NO.) or that stimulates endogenous production of NO or EDRF in vivo; and (iii) uses for them in preventing and/or treating respiratory disorders.

摘要翻译： 公开的是（i）直接或间接连接到NO或NO 2基团或基团上的基团的类固醇，β-激动剂，抗胆碱能药，肥大细胞稳定剂和磷酸二酯酶（PDE）抑制剂的化合物 其在体内刺激NO或EDRF的内源性产生; （ii）类固醇，β-激动剂，抗胆碱能药物，肥大细胞稳定剂和PDE抑制剂的组合物，其可任选地被至少一个NO或NO 2个部分取代，或刺激内源性产生NO 或EDRF，以及作为带电物质，即亚硝酸盐（硝酸）或硝酰基（NO +）的一氧化氮，或NOX + 作为中性物种，一氧化氮（NO））或者在体内刺激NO或EDRF的内源性产生; 和（iii）用于预防和/或治疗呼吸系统疾病。

公开(公告)号：US20050222243A1

公开(公告)日：2005-10-06

申请号：US11134358

申请日：2005-05-23

申请人： Richard Earl ,  Maiko Ezawa ,  Xinqin Fang ,  David Garvey ,  Ricky Gaston ,  Subhash Khanapure ,  L. Gordon Letts ,  Chia-En Lin ,  Ramani Ranatunga ,  Stewart Richardson ,  Joseph Schroeder ,  Cheri Stevenson ,  Shiow-Jyi Wey

发明人： Richard Earl ,  Maiko Ezawa ,  Xinqin Fang ,  David Garvey ,  Ricky Gaston ,  Subhash Khanapure ,  L. Gordon Letts ,  Chia-En Lin ,  Ramani Ranatunga ,  Stewart Richardson ,  Joseph Schroeder ,  Cheri Stevenson ,  Shiow-Jyi Wey

IPC分类号： C07D295/08 ,  A61K31/21 ,  A61K31/405 ,  A61K31/445 ,  A61K45/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/10 ,  A61P1/14 ,  A61P3/04 ,  A61P17/02 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07C203/04 ,  C07C205/40 ,  C07C205/56 ,  C07C219/10 ,  C07C229/42 ,  C07C235/08 ,  C07C235/12 ,  C07C235/34 ,  C07C235/42 ,  C07C237/08 ,  C07C243/28 ,  C07C271/16 ,  C07C271/64 ,  C07C291/02 ,  C07C311/17 ,  C07C317/18 ,  C07C317/32 ,  C07C317/46 ,  C07C323/12 ,  C07C327/28 ,  C07D209/18 ,  C07D209/28 ,  C07D211/22 ,  C07D211/56 ,  C07D493/04 ,  C07F9/40 ,  C07D209/20

CPC分类号： C07D493/04 ,  C07C291/02 ,  C07C311/17 ,  C07C317/18 ,  C07C323/12 ,  C07C327/28 ,  C07D209/18 ,  C07D211/22 ,  C07D211/56

摘要： The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

摘要翻译： 本发明描述了新型亚硝化非甾体抗炎药（NSAID）及其药学上可接受的盐，以及包含至少一种亚硝化NSAID的新组合物，以及任选地至少一种捐赠，转移或释放一氧化氮的化合物，刺激一氧化氮的内源性合成 升高内源性内源性松弛因子水平，或是一氧化氮合酶的底物和/或至少一种治疗剂。 本发明还提供了包含至少一种亚硝化NSAID和至少一种捐赠，转移或释放一氧化氮的化合物的新型组合物，提高内源性内皮衍生的舒张因子水平，刺激一氧化氮的内源性合成，或是一氧化氮的底物 合酶和/或至少一种治疗剂。 本发明还提供了包含至少一种亚硝化NSAID和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新型试剂盒。 本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗胃肠道疾病; 促进伤口愈合; 用于治疗和/或预防由使用非甾体抗炎化合物引起的胃肠道，肾脏和/或呼吸道毒性物质; 用于治疗炎性疾病状态和/或病症; 并用于治疗和/或预防眼科疾病和/或病症。