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31.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of breast cancer 审中-公开新的核苷酸和氨基酸序列，以及其用于诊断乳腺癌的测定和方法公开(公告)号：US20060183131A1
公开(公告)日：2006-08-17
申请号：US11043842
申请日：2005-01-27
申请人： Amir Toporik , Dvir Dahary , Rotem Sorek , Sarah Pollock , Zurit Levine , Pinchas Akiva , Alexander Diber , Amit Novik , Osnat Sella-Tavor , Michal Ayalon-Soffer , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Naomi Keren , Maxim Shklar
发明人： Amir Toporik , Dvir Dahary , Rotem Sorek , Sarah Pollock , Zurit Levine , Pinchas Akiva , Alexander Diber , Amit Novik , Osnat Sella-Tavor , Michal Ayalon-Soffer , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Naomi Keren , Maxim Shklar
CPC分类号： G01N33/57415 , C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
摘要翻译： 乳腺癌的新型标记物既敏感又准确。 这些标志物在乳腺癌中特异性地过表达，与正常的乳腺组织相反。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与乳腺癌的可能诊断相关的信息。 本发明的标记物单独或组合显示乳腺癌与非癌状态之间的高度差异检测。
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32.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 有权新型核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法公开(公告)号：US20060172311A1
公开(公告)日：2006-08-03
申请号：US11043824
申请日：2005-01-27
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
CPC分类号： G01N33/6893 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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33.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer 有权新型核苷酸和氨基酸序列，以及其用于诊断前列腺癌的测定和方法公开(公告)号：US20060051774A1
公开(公告)日：2006-03-09
申请号：US11043806
申请日：2005-01-27
申请人： Dvir Dahary , Sarah Pollock , Zurit Levine , Rotem Sorek , Michal Ayalon-Soffer , Pinchas Akiva , Amir Toporik , Osnat Sella-Tavor , Shirley Sameah-Greenwald
发明人： Dvir Dahary , Sarah Pollock , Zurit Levine , Rotem Sorek , Michal Ayalon-Soffer , Pinchas Akiva , Amir Toporik , Osnat Sella-Tavor , Shirley Sameah-Greenwald
CPC分类号： C07K14/705 , C07K14/47 , C07K14/82 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57434
摘要： Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as opposed to normal prostate tissue and/or BPH. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of prostate cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between prostate cancer and non-cancerous states.
摘要翻译： 前列腺癌的新型标记既灵敏又准确。 此外，这些标记能够区分前列腺癌和良性前列腺增生（“BPH”）。 与正常的前列腺组织和/或BPH相反，这些标记物在前列腺癌中过度表达。 这些标记物在患者样品中单独或组合的测量提供了诊断者可以与前列腺癌的可能诊断相关的信息。 本发明的标记物单独或组合显示前列腺癌与非癌状态之间的高度差异检测。
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公开(公告)号：US09428586B2
公开(公告)日：2016-08-30
申请号：US13512921
申请日：2010-11-30
申请人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
发明人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
IPC分类号： A61K39/395 , C07K16/30 , C07K16/40 , C12N15/113 , C12N9/24
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
摘要： The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
摘要翻译： 在至少一些方面，本发明是肝素酶的剪接变体，以及诊断试剂盒和使用方法，以及基于其的治疗剂和使用方法以及与其特异性结合的抗体。
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公开(公告)号：US20120301475A1
公开(公告)日：2012-11-29
申请号：US13512921
申请日：2010-11-30
申请人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
发明人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
IPC分类号： C07K16/40 , G01N33/573 , G01N33/574 , A61N5/00 , A61K39/395 , A61P35/00 , A61P35/02 , C12N5/20 , C12Q1/70
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
摘要： The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
摘要翻译： 在至少一些方面，本发明是肝素酶的剪接变体，以及诊断试剂盒和使用方法，以及基于其的治疗剂和使用方法以及与其特异性结合的抗体。
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公开(公告)号：US20120129776A1
公开(公告)日：2012-05-24
申请号：US11901939
申请日：2007-09-18
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
IPC分类号： A61K38/08 , C07K14/47 , C07K7/08 , C07K2/00 , C07H21/00 , A61K48/00 , C07K16/18 , A61P9/12 , A61P9/00 , A61P9/10 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P3/00 , A61P11/00 , A61P17/02 , A61P19/08 , A61P13/02 , A61P15/00 , A61P7/00 , A61P37/00 , A61P35/00 , A61P13/12 , A61P17/14 , A61P21/00 , A61P9/04 , C07K19/00 , A61P7/02 , A61K38/17 , C07K7/06
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体活化相关的疾病。
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公开(公告)号：US07939634B2
公开(公告)日：2011-05-10
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，使用本发明的新型多肽和多核苷酸作为诊断标记。
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38.发明申请HEPATOCYTE GROWTH FACTOR RECEPTOR SPLICE VARIANTS AND METHODS OF USING SAME 审中-公开肝细胞生长因子受体拮抗剂变异体及其使用方法公开(公告)号：US20100183573A1
公开(公告)日：2010-07-22
申请号：US12709269
申请日：2010-02-19
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran , Dvir Dahary , Liat Mintz , Hanqing Xie
IPC分类号： A61K38/16 , C07K14/00 , C07H21/04 , C12N15/63 , C12N1/21 , A61K31/7088 , A61K35/74 , A61K35/66 , C12N1/19 , C12N5/10 , A61K35/64 , A61K35/12 , A61P35/02 , A61P9/10 , A61P37/00
CPC分类号： C07K14/71 , A61K38/00 , C07K16/248 , C07K2317/34 , C07K2317/55 , C07K2317/73
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
摘要翻译： 提供了作为c-Met的剪接变体，肝细胞生长因子的受体和编码其的多核苷酸的新型多肽。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。
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39.发明申请Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of use Thereof for Diagnosis of Ovarian Cancer 有权新型核苷酸和氨基酸序列，以及用于诊断卵巢癌的检测方法公开(公告)号：US20100124786A1
公开(公告)日：2010-05-20
申请号：US12354641
申请日：2009-01-15
申请人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/156 , Y10T436/143333
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。
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40.发明申请Novel nucleotide and amino acid sequences, and assays methods of use thereof for diagnosis of colon cancer 审中-公开新型核苷酸和氨基酸序列及其用于诊断结肠癌的测定方法公开(公告)号：US20090215046A1
公开(公告)日：2009-08-27
申请号：US11976324
申请日：2007-10-23
申请人： Rotem Sorek , Michal Ayalon-Soffer , Dvir Dahary , Amit Novik , Amir Toporik , Alexander Diber , Guy Kol , Sarah Pollock , Zurit Levine , Gad S. Cojocaru , Ronen Shemesh , Yossi Cohen , Osnat Sella-Tavor , Shirley Sameah-Greenwald , Shira Walach
发明人： Rotem Sorek , Michal Ayalon-Soffer , Dvir Dahary , Amit Novik , Amir Toporik , Alexander Diber , Guy Kol , Sarah Pollock , Zurit Levine , Gad S. Cojocaru , Ronen Shemesh , Yossi Cohen , Osnat Sella-Tavor , Shirley Sameah-Greenwald , Shira Walach
IPC分类号： C12Q1/68 , C07H21/02 , C07K14/47 , C12N15/63 , C12Q1/02 , C07K17/00 , G01N33/574 , C12N5/06 , C12P21/00
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/57419
摘要： Novel markers for colon cancer that are both sensitive and accurate. These markers are overexpressed in colon cancer specifically, as opposed to normal colon tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of colon cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between colon cancer and non-cancerous states.
摘要翻译： 结肠癌的新型标志物既敏感又准确。 与正常结肠组织相反，这些标志物特异性地在结肠癌中过度表达。 这些标记物单独或组合在患者样本中的测量提供了诊断者可以与结肠癌可能诊断相关的信息。 本发明的标记物单独或组合显示结肠癌与非癌状态之间的高度差异检测。
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