公开(公告)号：US10265396B2

公开(公告)日：2019-04-23

申请号：US15708089

申请日：2017-09-18

申请人： NANO3D BIOSCIENCES INC

发明人： Glauco R. Souza

IPC分类号： A61K41/00 ,  A61N2/00 ,  C12N5/00 ,  A61L27/18 ,  A61L27/38 ,  A61L27/50 ,  G01N33/543 ,  G01N33/58 ,  B03C1/01 ,  B03C1/034 ,  B03C1/30

摘要： Methods of making and using a magnetic ECM are disclosed. The ECM comprises positively and negatively charged nanoparticles, wherein one of said nanoparticles contains a magnetically responsive element. When the magnetic ECM is seeded with cells, the cells will be magnetized and can be levitated for 3-D cell culture.

公开(公告)号：US10161221B2

公开(公告)日：2018-12-25

申请号：US14557709

申请日：2014-12-02

申请人： CONOCOPHILLIPS COMPANY

发明人： James A. Mills ,  Robert S. Redman ,  David L. Lee

IPC分类号： E21B36/00 ,  E21B43/24

摘要： A method and system for insulating wells using dual concentric vacuum insulated tubing layers with joints staggered with respect to one another. The method can be combined with other insulating methods, and well as with other subsidence mitigation techniques.

公开(公告)号：US10137143B1

公开(公告)日：2018-11-27

申请号：US14814130

申请日：2015-07-30

申请人： The Administrators of the Tulane Educational Fund

发明人： Eckhard Alt ,  Reza Izadpanah

IPC分类号： A61K31/7105 ,  A61K41/00 ,  A61K47/48 ,  A61K31/713

摘要： Treatment of tumors, especially breast cancer or glioblastoma tumors, by silencing RAB27A and/or TRAF3IP2, compositions and methods for same.

公开(公告)号：US10111729B1

公开(公告)日：2018-10-30

申请号：US15215356

申请日：2016-07-20

申请人： ORTHOACCEL TECHNOLOGIES INC.

发明人： Michael K Lowe ,  Tamsen Valoir

IPC分类号： A61C3/00 ,  A61C7/00 ,  A61C7/08 ,  A61N2/02 ,  A61N5/06 ,  A61N2/06 ,  A61C3/03 ,  A61B17/16 ,  A61C19/06 ,  A61N5/067

摘要： Night time use of removable orthodontic appliances coupled with night time use of accelerated orthodontic treatment modalities is provided. Accelerated orthodontic treatment modalities include micropulse vibrations, ultrasound vibrations, photobiomodulation, IR light, low-level laser therapy, pulsed EM fields, static magnetic fields, resonance vibrations, indirect electric current, direct electric current, pharmacological accelerators, surgical accelerators, decortication, osteoperforation, alveocentesis, and piezocision.

公开(公告)号：US09968422B2

公开(公告)日：2018-05-15

申请号：US14031832

申请日：2013-09-19

申请人： OrthoAccel Technologies, Inc.

发明人： Tamsen Valoir

IPC分类号： A61C7/00 ,  A61C7/08

CPC分类号： A61C7/008 ,  A61C7/08

摘要： Improved shapeable bite plates for use with orthodontic vibratory devices and devices offering other treatment modalities. The shapeable bite plates can be manually shaped to fit the Euro arch, arch form I, the Roth arch, and even widest Damon Arch.

公开(公告)号：US09913865B2

公开(公告)日：2018-03-13

申请号：US14980274

申请日：2015-12-28

申请人： InGeneron, Inc. ,  Alliance of Cardiovascular Researchers

发明人： Eckhard Alt ,  Tahereh Karimi

IPC分类号： C12N5/00 ,  A61K35/34 ,  C12N5/077 ,  C12N5/079 ,  A61K35/30

CPC分类号： A61K35/34 ,  A61K35/30 ,  C12N5/0618 ,  C12N5/0657 ,  C12N2501/60 ,  C12N2501/998 ,  C12N2506/08 ,  C12N2506/1384 ,  C12N2510/00

摘要： Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.

公开(公告)号：US09822378B2

公开(公告)日：2017-11-21

申请号：US14890799

申请日：2014-05-13

申请人： Robert Kruse

发明人： Robert Kruse

IPC分类号： C12N15/85 ,  C12N15/115 ,  C12Q1/68 ,  A61K48/00

CPC分类号： C12N15/85 ,  A61K48/00 ,  C12N15/115 ,  C12N2310/16 ,  C12N2800/50 ,  C12N2830/42 ,  C12N2840/203 ,  C12N2840/44 ,  C12N2999/007 ,  C12Q1/6865 ,  C12Q2521/119 ,  C12Q2531/125

摘要： A circular mRNA molecule possessing features resembling native mammalian mRNA demonstrates improved translation, while retaining the properties of an extremely long half-life inside cells. This circular mRNA is functional inside mammalian cells, being able to compete against native cellular mRNAs for the eukaryotic translation initiation machinery. The invention possesses additional RNA elements compared to a previous invention containing only an IRES element for successful in vitro or in vivo translation.

公开(公告)号：US09789235B2

公开(公告)日：2017-10-17

申请号：US14601205

申请日：2015-01-20

申请人： Halcyon Biomedical, Incorporated ,  The Administrators of the Tulane Educational Fund

发明人： Sean C. Gifford ,  Sergey S. Shevkoplyas

IPC分类号： A61M1/02 ,  A61M1/36 ,  B01D61/18 ,  B01D61/14 ,  B01D21/24 ,  B01D21/28 ,  B01D21/00

CPC分类号： A61M1/0272 ,  A61M1/029 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3695 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2202/0439 ,  B01D21/006 ,  B01D21/2444 ,  B01D21/28 ,  B01D61/14 ,  B01L3/502746 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2400/086

摘要： Described are devices, methods, and kits for controlled incremental filtration (CIF), as well as methods of designing CIF devices. For example, a method for CIF may modulate a concentration of particles of a desired size in a fluid. The fluid including the particles may be flowed along a flow path through a central channel to contact a plurality of gaps that fluidically couple the central channel to at least one adjacent side channel network. Flow resistance may be decreased along at least a portion of the flow path effective to modulate the concentration of particles. The method may include selecting the plurality of gaps to be larger than the particles. The method may include causing a consistent flow fraction fgap in the central channel to traverse each gap in the plurality of gaps and flow through the at least one side channel network along the flow path.

公开(公告)号：US09688955B2

公开(公告)日：2017-06-27

申请号：US14536388

申请日：2014-11-07

申请人： NANO3D BIOSCIENCES INC.

发明人： Glauco R. Souza

IPC分类号： C12N13/00 ,  C12N5/00 ,  C12N5/07 ,  C12Q1/02 ,  C12Q1/24 ,  B03C1/015 ,  B03C1/30 ,  B82Y25/00 ,  G01N33/543 ,  G01N33/544 ,  G01R33/12 ,  H01F1/00 ,  H01F1/08 ,  H01F1/113 ,  H01F1/44 ,  C40B30/04 ,  G01N33/566 ,  G01N33/68

CPC分类号： C12N5/0062 ,  B03C1/015 ,  B03C1/30 ,  B03C2201/26 ,  B82Y25/00 ,  C12N5/00 ,  C12N2513/00 ,  C12N2529/00 ,  C12N2531/00 ,  C12N2533/10 ,  C12N2533/32 ,  G01N33/54326 ,  G01N33/544 ,  G01R33/1269 ,  H01F1/0045 ,  H01F1/0063 ,  H01F1/083 ,  H01F1/113 ,  H01F1/445 ,  Y10S977/773 ,  Y10S977/89 ,  Y10S977/904 ,  Y10S977/923

摘要： A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it will magnetize those cells. The magnetized cells can then be washed to remove the magnetic nanoparticle assembly and the magnetized cells manipulated in a magnetic field.

公开(公告)号：US09671413B2

公开(公告)日：2017-06-06

申请号：US13884195

申请日：2011-11-11

申请人： John T. McDevitt ,  Nicolaos Christodoulides ,  Pierre N. Floriano ,  Ian Thompson

发明人： John T. McDevitt ,  Nicolaos Christodoulides ,  Pierre N. Floriano ,  Ian Thompson

IPC分类号： G01N33/68 ,  G01N33/574 ,  G01N33/543 ,  C40B40/10

CPC分类号： G01N33/689 ,  C40B40/10 ,  G01N33/54386 ,  G01N33/57434

摘要： The invention relates to point of care diagnostic disposables, devices, methods, and systems for diagnosing or predicting prostate cancer. The present invention employs biomarker specific reagents in disposable cassettes or lab cards for use as analyzers, as well as software to evaluate and report test results. The system promises to improve point of care in vitro diagnostics.