-
公开(公告)号：US20180264046A1
公开(公告)日：2018-09-20
申请号：US15914782
申请日：2018-03-07
发明人： Eckhard ALT , Tahereh KARIMI
CPC分类号： A61K35/34 , A61K35/30 , C12N5/0618 , C12N5/0657 , C12N2501/60 , C12N2501/998 , C12N2506/08 , C12N2506/1384 , C12N2510/00
摘要： Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
-
公开(公告)号：US20230250428A1
公开(公告)日：2023-08-10
申请号：US18165760
申请日：2023-02-07
发明人： Eckhard U. ALT , Reza IZADPANAH , Amin IZADPANAH
IPC分类号： C12N15/113 , C12N15/63 , A61P35/04
CPC分类号： C12N15/113 , C12N15/63 , A61P35/04 , C12N2310/11
摘要： A method and composition for treating a subject having a difficult to treat tumor is described. A TRAF3IP2 silencer is administered to the subject, preferably together with other synergistic medication such as chemotherapy, immunotherapies or other anticancer medication, that given alone are less or not successful for treating this special tumor, to increase relapse free survival. The TRAF3IP2 silencer in conjunction with other synergistic medication can additionally be used to effectively treat or prevent metastasis in a subject having an otherwise difficult to treat tumor.
-
公开(公告)号：US20220265741A1
公开(公告)日：2022-08-25
申请号：US17670789
申请日：2022-02-14
IPC分类号： A61K35/768 , C12N7/00 , C12N15/86 , C12N15/113 , A61K31/7105 , A61P35/00
摘要： Novel engineered oncolytic protoparvoviruses are described to be used in cancer therapy. The engineered protoparvoviruses contain at least one deletion in the untranslated region and a silencer sequence that remains stably integrated into the viral genome during extensive virus propagation. The novel viruses can be used for the silencing of relevant cancer-related genes, providing to the virus a new anticancer mechanism of action.
-
公开(公告)号：US10328056B2
公开(公告)日：2019-06-25
申请号：US15329970
申请日：2015-07-29
IPC分类号： A61K9/00 , A61K38/17 , A61K38/19 , C07K16/24 , C07K16/28 , A61K39/395 , A61K31/416 , A61K45/06 , A61K35/35 , A61K35/76 , C12N7/00
摘要： This invention relates generally to compositions and methods for treatment of pancreatic cancer. The present invention relates more particularly to use of JNK inhibition together with administration of TRAIL to selectively suppress cancer stem cells.
-
公开(公告)号：US10905722B2
公开(公告)日：2021-02-02
申请号：US15914782
申请日：2018-03-07
发明人： Eckhard Alt , Tahereh Karimi
摘要： Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
-
公开(公告)号：US09913865B2
公开(公告)日：2018-03-13
申请号：US14980274
申请日：2015-12-28
发明人： Eckhard Alt , Tahereh Karimi
CPC分类号： A61K35/34 , A61K35/30 , C12N5/0618 , C12N5/0657 , C12N2501/60 , C12N2501/998 , C12N2506/08 , C12N2506/1384 , C12N2510/00
摘要： Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
-
公开(公告)号：US20170258765A1
公开(公告)日：2017-09-14
申请号：US15329970
申请日：2015-07-29
IPC分类号： A61K31/416 , A61K39/395 , C12N7/00 , A61K9/00 , A61K35/35 , A61K35/76 , A61K38/17 , C07K16/28
CPC分类号： A61K31/416 , A61K9/0019 , A61K9/0053 , A61K35/35 , A61K35/76 , A61K38/1761 , A61K38/1793 , A61K38/191 , A61K39/39541 , A61K39/3955 , A61K45/06 , C07K16/244 , C07K16/2866 , C07K2317/76 , C12N7/00 , A61K2300/00
摘要： This invention relates generally to compositions and methods for treatment of pancreatic cancer. The present invention relates more particularly to use of JNK inhibition together with administration of TRAIL to selectively suppress cancer stem cells.
-
公开(公告)号：US20170182099A1
公开(公告)日：2017-06-29
申请号：US14980274
申请日：2015-12-28
发明人： Eckhard ALT , Tahereh KARIMI
CPC分类号： A61K35/34 , A61K35/30 , C12N5/0618 , C12N5/0657 , C12N2501/60 , C12N2501/998 , C12N2506/08 , C12N2506/1384 , C12N2510/00
摘要： Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.017 秒)
