Invention Grant
- Patent Title: Induced pacemaker and Purkinje cells from adult stem cells
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Application No.: US14980274Application Date: 2015-12-28
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Publication No.: US09913865B2Publication Date: 2018-03-13
- Inventor: Eckhard Alt , Tahereh Karimi
- Applicant: InGeneron, Inc. , Alliance of Cardiovascular Researchers
- Applicant Address: US TX Houston US LA New Orleans
- Assignee: InGeneron Inc.,Alliance of Cardiovascular Research
- Current Assignee: InGeneron Inc.,Alliance of Cardiovascular Research
- Current Assignee Address: US TX Houston US LA New Orleans
- Agency: Boulware & Valoir
- Main IPC: C12N5/00
- IPC: C12N5/00 ; A61K35/34 ; C12N5/077 ; C12N5/079 ; A61K35/30
Abstract:
Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
Public/Granted literature
- US20170182099A1 Induced Pacemaker and Purkinje Cells from Adult Stem Cells Public/Granted day:2017-06-29
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