公开(公告)号：US20040038386A1

公开(公告)日：2004-02-26

申请号：US10363577

申请日：2003-03-04

Inventor： Wolfgang Zesch ,  Martin Andreas Bopp ,  Michael Pawlak

IPC: C12M001/34 ,  G01J003/42 ,  G01J003/427

CPC classification number: G01N21/6452 ,  G01N21/648 ,  G01N21/7703 ,  G01N2021/6419

Abstract: The invention relates to embodiments of an optical system for luminescence determination, comprising two or more excitation light sources, a sensor platform and an optical component with several discrete facets for beam deflection towards the sensor platform. Further subjects of the invention are methods for luminescence determination with an optical system according to the invention and analytical systems, as well as the use of these methods for quantitative affinity sensing and for various other applications. The aim of the present invention is to provide optical and analytical measuring devices for highly sensitive detection of one or more analytes, using a multitude of measurement areas on a common carrier.

Abstract translation: 本发明涉及用于发光确定的光学系统的实施例，其包括两个或更多个激发光源，传感器平台和具有用于朝向传感器平台的光束偏转的多个离散面的光学部件。 本发明的其它主题是使用根据本发明的光学系统和分析系统进行发光测定的方法，以及这些方法用于定量亲和力感测和各种其它应用的方法。 本发明的目的是提供使用在公共载体上的多个测量区域对一种或多种分析物进行高灵敏度检测的光学和分析测量装置。

公开(公告)号：US20030223060A1

公开(公告)日：2003-12-04

申请号：US10063960

申请日：2002-05-30

Applicant: General Electric Company

Inventor： John Frederick Graf ,  Hongyi Zhou

IPC: G01J003/42

CPC classification number: G01J3/46 ,  G01J3/0251 ,  G01J3/463 ,  G01J3/504

Abstract: Method, system and computer product for formulating a bi-directional color match. In this disclosure, a computing unit obtains spectral measurements of a target bi-directional color. The computing unit uses a bi-directional color formulation tool determine a combination of pigments, dyes and platelet-shaped pigments that generates spectral measurements that match the spectral measurements of the target bi-directional color.

Abstract translation: 用于制定双向色彩匹配的方法，系统和计算机产品。 在本公开中，计算单元获得目标双向颜色的光谱测量。 计算单元使用双向颜色配方工具来确定产生与目标双向颜色的光谱测量相匹配的光谱测量的颜料，染料和血小板形颜料的组合。

公开(公告)号：US20030087282A1

公开(公告)日：2003-05-08

申请号：US10229204

申请日：2002-08-26

Applicant: Hitachi, Ltd. Incorporation: Japan

Inventor： Yoshitada Oshida ,  Satoshi Takahashi ,  Kenji Yasuda ,  Taisaku Seino

IPC: C12Q001/68 ,  G06K009/00 ,  G01J003/42 ,  G01J003/427 ,  G01N033/543

CPC classification number: G01N21/6428 ,  G01J3/4406 ,  G01N21/6452

Abstract: A wide-dynamic range, high-resistivity and high-speed method of stably obtaining fluorescent images of two or more samples which may includes a fluorescent material, comprising the steps of: disposing each of said samples onto each of two or more compartments which an area on a substrate is split into; sequentially irradiating said compartments with an exciting light wherein each of said compartments is irradiated with said exciting light with the intensity changed; detecting one or more fluorescent lights as generated from each of said samples corresponding to said changed intensity of said exciting light every each of said samples; determining the true value of fluorescence as generated from each of said samples by using information on said one or more fluorescent lights as detected every each of said samples; and obtaining a fluorescent image of each of said samples by using said true value of fluorescence from each of said samples, and an apparatus for carrying out the same are provided.

Abstract translation: 一种宽动态范围，高电阻率和高速方法，可稳定地获得可包括荧光材料的两个或多个样品的荧光图像，其包括以下步骤：将每个所述样品置于两个或更多隔室中的每一个上， 将基板上的区域分割成; 用激发光顺序地照射所述隔室，其中每个所述隔间用强度改变的所述激发光照射; 从每个所述样本中检测出一个或多个荧光灯，其对应于所述每个所述样本的所述激发光的所述改变的强度; 通过使用每个所述样品检测到的所述一个或多个荧光灯的信息来确定从每个所述样品产生的荧光的真实值; 并且通过使用来自每个所述样品的所述真实值的荧光获得每个所述样品的荧光图像，并且提供了用于进行所述样品的装置。

公开(公告)号：US20030063276A1

公开(公告)日：2003-04-03

申请号：US10119042

申请日：2002-04-10

Applicant: FOSS TECATOR AB

Inventor： Robert Sjodin

IPC: G01J003/42 ,  G01N021/35

CPC classification number: G01N21/3563 ,  A01D41/1277 ,  G01N21/359 ,  G01N2001/021

Abstract: A method for segregating qualities of an agricultural product during processing of the product comprises the step of setting a desired range of a measurement value (2). The measurement value represents a property of the product and defines a first quality of the product for which the measurement value is inside the range and a second quality of the product for which the measurement value is outside the range. The method further comprises the step of analyzing (4) the quality of the product that is being processed. The step of analyzing comprises the steps of continuously extracting samples of the product (4a), irradiating each sample by electromagnetic radiation (4d), spatially separating electromagnetic radiation of different wavelengths (4e), and detecting electromagnetic radiation emitted from the sample (4f). The step of detecting produces intensity signals indicative of detected electromagnetic radiation of different wavelengths. The step of analyzing further comprises the steps of determining a sample value of said property of the product from the intensity signals, and determining a measurement value (4g) from at least one sample value. The method further comprises the step of separating the product of said first quality from the product of said second quality on the combine.

Abstract translation: 在产品处理期间分离农产品的质量的方法包括设定测量值（2）的期望范围的步骤。 测量值表示产品的属性，并且定义测量值在该范围内的产品的第一质量以及测量值在该范围之外的产品的第二质量。 该方法还包括分析（4）正在处理的产品的质量的步骤。 分析步骤包括以下步骤：连续提取产品（4a）的样品，通过电磁辐射（4d）照射每个样品，在空间上分离不同波长的电磁辐射（4e），并检测从样品（4f）发射的电磁辐射， 。 检测步骤产生表示不同波长的检测电磁辐射的强度信号。 分析步骤还包括以下步骤：根据强度信号确定产品的所述属性的样本值，以及从至少一个采样值确定测量值（4g）。 该方法还包括将所述第一品质的商品与所述第二品质的商品在组合上分离的步骤。

公开(公告)号：US20030059855A1

公开(公告)日：2003-03-27

申请号：US10180374

申请日：2002-06-26

Applicant: SRU Biosystems, LLC

Inventor： Brian T. Cunningham ,  Peter Y. Li

IPC: C12Q001/68 ,  G01N033/53 ,  G01N033/542 ,  C12M001/34 ,  G01J003/42 ,  G01J003/427

CPC classification number: G01N21/253 ,  B01L3/5085 ,  C12Q1/68 ,  G01J3/42 ,  G01N21/31 ,  G01N21/4788 ,  G01N21/55 ,  G01N21/75 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7776 ,  G02B5/1809

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An instrument system for detecting a biochemical interaction on a biosensor. The system includes an array of detection locations comprises a light source for generating collimated white light. A beam splitter directs the collimated white light towards a surface of a sensor corresponding to the detector locations. A detection system includes an imaging spectrometer receiving the reflected light and generating an image of the reflected light.

Abstract translation: 用于检测生物分子相互作用的方法和装置。 不需要使用标签，并且可以以高通量的方式执行方法。 用于检测生物传感器上的生物化学相互作用的仪器系统。 该系统包括一组检测位置，包括用于产生准直白光的光源。 分束器将准直的白光引导到对应于检测器位置的传感器的表面。 检测系统包括接收反射光并产生反射光的图像的成像光谱仪。

公开(公告)号：US20030053050A1

公开(公告)日：2003-03-20

申请号：US09682365

申请日：2001-08-24

Inventor： Radislav Alexandrovich Potyrailo ,  Patrick Joseph McCloskey ,  James Day

IPC: G01J003/42

CPC classification number: G01J3/42 ,  G01J3/28

Abstract: The present invention relates to methods and devices for in-situ measurement of reaction components of interest during manufacturing of polycarbonate by melt polymerization. The present invention describes irradiating a molten polymer sample with UV/visible light, and generating an absorbance profile correlated to Fries products as well as uncapped phenolic groups in the sample. The methods and apparatus of the invention are suitable for monitoring of Fries products in reactions ranging in size from small scale combinatorial formats to production scale reactors. Also included in methods of the invention are univariate and multivariate analysis for prediction of linear Fries, branched Fries and uncapped phenolic end-groups in unknowns.

Abstract translation: 本发明涉及通过熔融聚合在聚碳酸酯制造过程中原位测量感兴趣的反应组分的方法和装置。 本发明描述了用UV /可见光照射熔融聚合物样品，并产生与Fries产品相关的吸光度分布以及样品中未封端的酚基。 本发明的方法和装置适用于在尺寸从小规模组合形式到生产规模反应器的反应中监测薯条产品。 本发明方法中还包括单变量和多变量分析，用于预测未知物中的线性薯条，分枝油炸饼和未封端的酚类末端基团。

公开(公告)号：US20030049693A1

公开(公告)日：2003-03-13

申请号：US10242778

申请日：2002-09-13

Inventor： M. Cynthia Goh ,  Richard Loo ,  Jane B. Goh ,  Richard McAloney

IPC: G01N033/53 ,  G01N033/542 ,  C12M001/34 ,  G01J003/42 ,  G01J003/447

CPC classification number: G01N33/54373 ,  Y10S435/808 ,  Y10S436/805

Abstract: The present invention relates to a method and apparatus for detecting analytes in a medium, and more particularly the present invention relates to an assay based on light diffraction which appears or changes upon the binding of analytes to their specific receptors laid out in patterns on a substrate, which has high sensitivity due to the appropriate choice of such patterns. The present invention is based on the principle that the pattern of recognition elements, which gives rise to the diffraction of the incident light in a diffraction-based assay, can be chosen in such a way so as to facilitate detection, and to enhance the signal to be detected compared to known gratings such as parallel straight lines. In one aspect the substrate itself has a surface topography designed to enhance the diffraction pattern signals. In another aspect the substrate is a diffractive optic element having the analyte-specific receptors affixed to the optic element. In another aspect the diffractive optic element is used as a master stamp for producing patterns of analyte-specific receptors which give the signal enhancements.

Abstract translation: 本发明涉及一种用于检测培养基中分析物的方法和装置，更具体地说，本发明涉及一种基于光衍射的测定法，其在分析物与其在基底上的图案中布置的特定受体结合时出现或改变 ，其由于适当选择这种图案而具有高灵敏度。 本发明基于这样的原理，即可以以这样的方式来选择在衍射测定中引起入射光的衍射的识别元件的图案，以便于检测，并增强信号 与已知的光栅例如平行直线相比被检测。 在一个方面，衬底本身具有设计用于增强衍射图案信号的表面形貌。 在另一方面，基底是具有附着于光学元件的分析物特异性受体的衍射光学元件。 在另一方面，衍射光学元件用作产生赋予信号增强的分析物特异性受体的图案的主印模。

公开(公告)号：US20030048440A1

公开(公告)日：2003-03-13

申请号：US10220073

申请日：2002-08-27

Inventor： Thore Lindgren ,  Johan Carlsson ,  Ulrika Backlund

IPC: G01J003/42 ,  G01N021/25

CPC classification number: G01N21/3554 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/85 ,  G01N21/89 ,  G01N33/46

Abstract: Methods for the continuous determination of the properties of a flow of wood fibers for use in the production of fiberboard are disclosed including determining reference value characteristics for calibration samples of the fibers, determining predetermined relationships between those reference value characteristics and measured spectral values for the fibers utilizing multivariant statistical regression methods, measuring reflectance spectral values for the fibers illuminated by light, and determining the fiber characteristics relating to the properties from the measured spectral values utilizing the predetermined relationship.

Abstract translation: 公开了用于连续测定用于生产纤维板的木纤维流动性能的方法，包括确定纤维的校准样品的参考值特性，确定这些参考值特性与纤维的测量光谱值之间的预定关系 利用多变量统计回归方法，测量由光照射的纤维的反射光谱值，以及利用预定关系从测量的光谱值确定与特性相关的光纤特性。

公开(公告)号：US20030011767A1

公开(公告)日：2003-01-16

申请号：US10193291

申请日：2002-07-12

Applicant: Minolta Co., Ltd.

Inventor： Kenji Imura ,  Susumu Ichikawa

IPC: G01J003/42

CPC classification number: G01J3/10 ,  G01J3/0254 ,  G01J3/28 ,  G01J2003/2866

Abstract: A spectral characteristic measuring apparatus is provided with a memory and a CPU. The memory stores a spectral profile output from a sample light sensor array when light from a lamp is received, and a plurality of spectral profiles to be output from the sensor array at each displaced position in the case where a light separator is displaced relative to a grating member of the sensor array at a certain pitch stepwise in a wavelength diffusing direction. The CPU controls the lamp to emit light in a state that a white plate for calibration is disposed as a sample, compares a spectral profile output from the sensor array for correction with each spectral profile stored in the memory, and sets a displacement amount corresponding to the spectral profile that is most approximate to the corrective spectral profile as a wavelength shift correction amount.

Abstract translation: 光谱特征测量装置具有存储器和CPU。 存储器存储当来自灯的光被接收时来自样本光传感器阵列的光谱分布输出，以及在光分离器相对于光源分离器移位的情况下，在每个位移位置处从传感器阵列输出的多个光谱轮廓 传感器阵列的光栅构件在波长扩散方向上逐步地以一定的间距。 在将校准用白板作为样本配置的状态下，CPU控制灯发光，将来自校正用传感器阵列的光谱分布图与存储在存储器中的各光谱分布进行比较，并设定与 作为波长偏移校正量最接近校正光谱分布的光谱分布。

公开(公告)号：US20020191183A1

公开(公告)日：2002-12-19

申请号：US09862247

申请日：2001-05-22

Applicant: Xerox Corporation

Inventor： Jagdish C. Tandon ,  Lingappa K. Mestha

IPC: G01J003/42

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/501 ,  G01J3/51 ,  G01J3/513 ,  G01J3/52 ,  G01J3/524 ,  G03G15/01 ,  G03G2215/00063 ,  G03G2215/00067 ,  H04N1/6033

Abstract: An improved and lower cost color spectrophotometer, especially suitable for on-line color printer color control systems, incorporating a low cost commercial imaging chip, which normally only forms part of a three row, three color, document imaging bar used for imaging documents in scanners, digital copiers, or multifunction products, having multiple photo-sites with at least three different color filters in three rows. This multiple photo-sites chip may be modified to also provide unfiltered photo-sites. This spectrophotometer may have a substantially reduced number of different LED or other spectral illumination sources, one of which may be for white light, yet provide multiple spectral data outputs from the differently filtered photo-sites being simultaneous illuminated by the light reflected from a color test target area which is being sequentially illuminated by the respective limited number of LEDs, enabling broad spectrum information and color control.

Abstract translation: 一种改进且成本较低的彩色分光光度计，特别适用于在线彩色打印机色彩控制系统，结合了低成本的商业成像芯片，通常仅形成扫描仪中成像文档的三行三色文档成像条的一部分 ，数字复印机或多功能产品，具有三行具有至少三种不同滤色片的多个照片位置。 可以修改该多个照片位置芯片，以提供未过滤的照片位置。 该分光光度计可以具有基本上减少数量的不同的LED或其它光谱照明源，其中一个可以用于白光，但是提供来自不同滤光的光点的多个光谱数据输出，由来自颜色测试反射的光同时照亮 目标区域由相应有限数量的LED顺序地照亮，从而实现广谱信息和颜色控制。