公开(公告)号：US20180162953A1

公开(公告)日：2018-06-14

申请号：US15882936

申请日：2018-01-29

Applicant: ASTUTE MEDICAL, INC.

Inventor： Ravi A. VIJAYENDRAN ,  Srivatsa VENKATASUBBARAO

IPC: C07K16/38 ,  G01N33/577

CPC classification number: C07K16/38 ,  C07K2317/34 ,  G01N33/577 ,  G01N2333/8146

Abstract: The invention provides TIMP2 immunoassays with improved clinical performance, particularly when used in the evaluation of renal injuries. The immunoassays rely on the selection and use of antibodies and antibody pairs that exhibit improved assay performance when used in complex clinical specimens such as biological fluids, and particularly when used in rapid assay formats such as lateral flow test devices.

公开(公告)号：US20170342162A1

公开(公告)日：2017-11-30

申请号：US15644530

申请日：2017-07-07

Applicant: Bayer HealthCare LLC

Inventor： Zhuozhi WANG ,  John E. MURPHY ,  Junliang PAN ,  Haiyan Jiang ,  Bing LIU

IPC: C07K16/38 ,  A61K39/395 ,  A61K39/00

Abstract: Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

公开(公告)号：US20170204140A1

公开(公告)日：2017-07-20

申请号：US15328309

申请日：2015-07-23

Applicant: Deakin University

Inventor： Cenk Suphioglu

IPC: C07K7/08 ,  C07K16/38

CPC classification number: C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  A61P25/28 ,  A61P37/08 ,  C07K14/8142 ,  C07K16/38 ,  C07K2317/34

Abstract: The present invention relates to a compositions and methods for treating and/or preventing neurologic disorders such as Alzheimer's disease and disorders associated with an increase of the Th2 immune response such as allergic inflammation.

公开(公告)号：US20150168410A1

公开(公告)日：2015-06-18

申请号：US14371088

申请日：2012-01-09

Applicant: Tao Wang ,  Xiangyun Qu ,  Fei Chen

Inventor： Tao Wang ,  Xiangyun Qu ,  Fei Chen

IPC: G01N33/574 ,  C07K16/38 ,  C12Q1/68

CPC classification number: G01N33/57419 ,  C07K14/8139 ,  C07K16/38 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N2333/8139

Abstract: In this invention, we disclosed and documented the applications of CST4 gene, mRNA of CST4, cDNA of CST4 splices, the corresponding amplicon of CST4-specific primers, cystatin S protein coded by CST4 gene and epitope peptide of CST4 in the diagnosis and prediction of colorectal cancer, and the detection method and testing kits of the above. This invention shall be applied in the diagnosis, dynamic monitoring and progression prediction of colorectal cancer. Methods mentioned in this invention features high sensitivity and reliability, which was verified by large-scale trial.

Abstract translation: 在本发明中，我们公开并记录了CST4基因的mRNA，CST4的mRNA，CST4剪接的cDNA，CST4特异性引物的相应扩增子，CST4基因编码的半胱氨酸蛋白酶抑制蛋白S蛋白和CST4的表位肽在诊断和预测中的应用 结肠直肠癌，以及上述的检测方法和检测试剂盒。 本发明应用于结肠直肠癌的诊断，动态监测和进展预测。 本发明提出的方法具有高灵敏度和可靠性，经大规模试验验证。

公开(公告)号：US20150064169A1

公开(公告)日：2015-03-05

申请号：US14389219

申请日：2013-03-14

Applicant: Bayer HealthCare LLC

Inventor： Zhuozhi Wang ,  Ruth Winter ,  John Murphy

IPC: C07K16/38

CPC classification number: C07K16/38 ,  A61K39/3955 ,  C07K14/745 ,  C07K16/36 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92

Abstract: This disclosure provides protease-regulated antibodies which specifically bind to tissue factor pathway inhibitor (TFPI). The antibodies are useful for treating bleeding disorders such as hemophilia.

Abstract translation: 本公开提供了特异性结合组织因子途径抑制剂（TFPI）的蛋白酶调节的抗体。 抗体可用于治疗出血性疾病如血友病。

公开(公告)号：US20150023920A1

公开(公告)日：2015-01-22

申请号：US14389086

申请日：2013-03-13

Applicant: Drexel University

Inventor： Alessandro Fatatis ,  Michael Russell ,  Qingxin (Cindy) Lui

IPC: C07K16/24 ,  C07K14/47 ,  A61K31/573 ,  A61K45/06 ,  C12N15/113 ,  A61K39/395 ,  A61K31/7088 ,  C07K16/38 ,  A61K38/17 ,  A61K38/21

CPC classification number: C07K16/245 ,  A61K31/573 ,  A61K31/7088 ,  A61K38/1793 ,  A61K38/217 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K14/47 ,  C07K16/24 ,  C07K16/38 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/31 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57484 ,  G01N2333/522 ,  G01N2333/545

Abstract: The invention includes a method of preventing or treating metastasis in a subject diagnosed with cancer, the method comprising determining whether at least one gene encoding one or more proteins is upregulated in a cancer tissue sample from the subject as compared to the level of expression of the at least one gene in a non-cancer control sample of the same tissue, and, if the at least one gene is upregulated in the cancer tissue sample from the subject, administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising one or more protein depleting agents.

Abstract translation: 本发明包括预防或治疗患有癌症的受试者的转移的方法，所述方法包括：与来自受试者的癌组织样品相比，确定编码一种或多种蛋白质的至少一种基因是否被上调 在相同组织的非癌症对照样品中的至少一个基因，以及如果所述至少一种基因在来自所述受试者的癌组织样品中上调，则向受试者施用治疗有效量的药物组合物，其包含一种或多种 更多的蛋白质消耗剂。

公开(公告)号：US08927220B2

公开(公告)日：2015-01-06

申请号：US13002224

申请日：2009-09-30

Applicant: Moon Chang Baek ,  Pyong Gon Moon ,  Yong Lim Kim

Inventor： Moon Chang Baek ,  Pyong Gon Moon ,  Yong Lim Kim

IPC: G01N33/573 ,  G01N33/68 ,  G01N33/564 ,  C07K16/38 ,  C07K16/40 ,  G01N33/543 ,  G01N1/40

CPC classification number: G01N33/6893 ,  C07K16/38 ,  C07K16/40 ,  G01N33/5436 ,  G01N33/564 ,  G01N33/573 ,  G01N33/6842 ,  G01N2001/4083 ,  G01N2333/4713 ,  G01N2333/79 ,  G01N2333/8125 ,  G01N2333/90287 ,  G01N2800/24 ,  G01N2800/347 ,  G01N2800/7095 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S530/811

Abstract: A protein used as a biomarker for diagnosing IgA nephropathy and TGBM (thin-glomerular-basement-membrane) using urine through a target proteomics method. A diagnosis biomarker protein and a kit for diagnosing IgA nephropathy and TGBM and predicting progress of the nephropathy in advance using the protein are provided. The degree of the progression of the disease can be grasped by detecting IgA nephropathy and TGBM, enabling early diagnosis and confirming progress from the patient's urine. In addition, a monoclonal antibody produced based on the diagnosis biomarker protein can be used for an immunoassay kit (ELISA, antibody coated tube test, lateral-flow test, potable biosensor). The monoclonal antibody is used in early diagnosis and progression detection of IgA nephropathy and development of a novel drug for the purpose of treatment.

Abstract translation: 用于通过靶蛋白质组学方法使用尿液作为诊断IgA肾病和TGBM（薄肾小球基底膜）的生物标志物的蛋白质。 提供诊断生物标记蛋白和用于诊断IgA肾病和TGBM的试剂盒，并预先使用蛋白质预测肾病的进展。 可以通过检测IgA肾病和TGBM来掌握疾病进展程度，从而能够早期诊断并确认患者尿液的进展情况。 此外，基于诊断生物标记蛋白产生的单克隆抗体可用于免疫测定试剂盒（ELISA，抗体包被管试验，侧流试验，饮用生物传感器）。 单克隆抗体用于IgA肾病的早期诊断和进展检测，并开发用于治疗目的的新型药物。

公开(公告)号：US07842788B2

公开(公告)日：2010-11-30

申请号：US12284131

申请日：2008-09-18

Applicant: Scott M. Silbiger ,  Raymond A. Koski

Inventor： Scott M. Silbiger ,  Raymond A. Koski

IPC: C12P21/08 ,  C07K16/00 ,  A61K39/395 ,  C07K16/38

CPC classification number: A61K38/57 ,  C07K14/8146

Abstract: The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.

公开(公告)号：US20050196390A1

公开(公告)日：2005-09-08

申请号：US10893323

申请日：2004-07-19

Applicant: Keith Langley ,  Yves DeClerck ,  Thomas Boone

Inventor： Keith Langley ,  Yves DeClerck ,  Thomas Boone

IPC: A61K38/00 ,  C07K14/81 ,  C07K16/38 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C07H21/04 ,  A61K38/54 ,  C12N9/99 ,  C12N15/09

CPC classification number: C07K16/38 ,  A61K38/00 ,  C07K14/8146 ,  C07K2319/02 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12N2800/108 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/702 ,  C12N2840/44

Abstract: A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.

公开(公告)号：US20050142137A1

公开(公告)日：2005-06-30

申请号：US10984960

申请日：2004-11-08

Applicant: Michael Gallo ,  Daniel Chui ,  Haihong Zhong ,  Gulshan Ara ,  William LaRochelle

Inventor： Michael Gallo ,  Daniel Chui ,  Haihong Zhong ,  Gulshan Ara ,  William LaRochelle

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/38 ,  C07K16/40

CPC classification number: C07K16/3069 ,  A01K2217/075 ,  A61K2039/505 ,  C07K16/38 ,  C07K2317/21 ,  C07K2317/73

Abstract: In accordance with the present invention, there are provided fully human monoclonal antibodies against secretory leukocyte protease inhibitor (SLPI) and antigen binding fragments thereof. Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules are provided. The invention provides antibodies and antigen-binding fragments thereof specifically bind to SLPI; act to neutralize SLPI activity; and can modulate SLPI effects.

Abstract translation: 根据本发明，提供了完全针对分泌白细胞蛋白酶抑制剂（SLPI）的人单克隆抗体及其抗原结合片段。 提供了编码核酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列。 本发明提供抗体及其抗原结合片段特异性结合SLPI; 行动以中和SLPI活动; 并可以调节SLPI效果。