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1.发明申请公开(公告)号：US20250065033A1
公开(公告)日：2025-02-27
申请号：US18941939
申请日：2024-11-08
Applicant: Bayer Healthcare LLC
Inventor： Corey Kemper , John Volkar , Christopher Lazzara , Matthias Burg
Abstract: A fluid injector system for use in administering to a patient a fluid in an injection protocol in connection with a diagnostic imaging procedure includes at least one display and a control device. The control device is programmed to determine, for each of the injection protocols performed by the fluid injector system, a component status for the at least one disposable component. The component status indicates whether use of the at least one disposable component was compliant with instructions for use applicable to the at least one disposable component. The control device is further programmed to enable the at least one display to display a compliance report. The compliance report includes one or more visual indicators providing visual feedback about compliance with the instructions for use based on the component status determined for each of the injection protocols performed using the fluid injector system.
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公开(公告)号：US12205715B2
公开(公告)日：2025-01-21
申请号：US17581648
申请日：2022-01-21
Applicant: Bayer Healthcare LLC
Inventor： Ralph Schriver , Arthur Uber, III , Janele Archibald , Matthew Brewer , Amy Chaya , Christopher Fiorentini , David Griffiths , Jacob Hartmann , Joseph Hulbert , Susan Michel , Janel Petrilli , Michael Pogozelec , Barry Skirble
Abstract: A method, system, and computer program product for predictive maintenance. A method may include receiving operation data associated with one or more injection systems, wherein the operation data includes one or more operation parameters associated with one or more operations of the one or more injection systems: determining one or more prediction scores for the one or more injection systems based on the operation data, wherein the one or more prediction scores include one or more predictions of one or more operation failures or misuses for the one or more injection systems; and providing maintenance data associated with the one or more operation failures or misuses, wherein the maintenance data is based on the one or more prediction scores.
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公开(公告)号：US12203110B2
公开(公告)日：2025-01-21
申请号：US16982433
申请日：2019-03-19
Applicant: CRISPR THERAPEUTICS AG , BAYER HEALTHCARE LLC
Inventor： Andre Cohnen , Moritz Schmidt , Wayne Coco , Michael Biag Gamalinda , Ashish Gupta , Christian Pitzler , Florian Richter , Jan Tebbe , Christopher Cheng , Ryo Takeuchi , Caroline W. Reiss
IPC: C12N9/22 , C12N15/11 , C12N15/113 , C12N15/90
Abstract: Aspects of this invention, inter alia, relate to novel systems for targeting, editing or manipulating DNA in a cell, using novel synthetic RNA-guided nucleases (sRGNs). The sRGNs are derived from wildtype or parental small type II CRISPR Cas9 endonucleases.
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公开(公告)号：US12194271B2
公开(公告)日：2025-01-14
申请号：US17843181
申请日：2022-06-17
Applicant: Bayer Healthcare LLC
Inventor： Damian Peter Francis Savio , Peter Sprada , Eric Siu , Barry Iddon , Bipin Salunkhe , Michael Spohn , Richard Sokolov , Matthew J. Leroch , Michael McDermott , Kevin Cowan
Abstract: A syringe manifold for a fluid injector assembly includes a middle body member defining an upper cavity and a lower cavity, the middle body member defining at least one fluid path in an upper surface of the middle body member and at least one fluid path in a lower surface of the middle body member, the middle body member defining at least two ports extending through the middle body member, the middle body member comprising an outlet for connection of the syringe manifold to at least one fluid delivery device; a lower body member received within the lower cavity of the middle body member, the lower body member comprising at least one connector for connection of the lower body member to a syringe assembly; and an upper body member received within the upper cavity of the middle body member.
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公开(公告)号：US20240270787A1
公开(公告)日：2024-08-15
申请号：US18168765
申请日：2023-02-14
Applicant: BAYER HEALTHCARE LLC
Inventor： HENDRI TJANDRA , XIAOYU PAN , RYAN ZOLYOMI , DEEPA SURENDAR
Abstract: What is described herein relates to a method for separating host cell proteins from proteins of interest, comprising the following steps
a) subjecting a mixture of host cell proteins and proteins of interest to at least a Protein A chromatography followed by a cation exchange chromatography (CEX) and up to two ion exchange chromatography (IEX) steps wherein one of the two ion exchange chromatography steps is a mixed mode chromatography (MM AEX/CEX) and the other one is an anion exchange membrane adsorber (MA AEX) in flow through mode OR
b) subjecting a mixture of host cell proteins and proteins of interest to non-ionic detergent during a Protein A chromatography wash step.-
Patent Agency Ranking
公开(公告)号：US20240269389A1
公开(公告)日：2024-08-15
申请号：US18646969
申请日：2024-04-26
Applicant: Bayer Healthcare LLC
Inventor： Michael Swantner , Michael McDermott
CPC classification number: A61M5/31513 , A61M2005/3123 , A61M2207/00
Abstract: A plunger, a syringe, system, and a method for increasing a seal between a sidewall of a plunger and a sidewall of a syringe are disclosed. The plunger includes a support ring and a cover disposed over and coupled to the support ring. A cavity defining a predetermined volume is defined between the support ring and the cover. The syringe includes a barrel defining an inner wall and the plunger inserted therein.
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公开(公告)号：US20240230702A9
公开(公告)日：2024-07-11
申请号：US18546806
申请日：2022-02-25
Applicant: Bayer HealthCare LLC
Inventor： William Barone , Ronald Brown , Curtis Pastor , Michael Swantner , Christopher Capone , Jaroslaw Wlodarczyk , Charles Lang
CPC classification number: G01P5/18 , A61M5/1452 , A61M5/365
Abstract: A fluid injector system includes at least one injector for pressurizing and delivering at least one fluid from at least one fluid reservoir, at least one fluid path section in fluid communication with the at least one injector and having a predetermined index of refraction, and a first proximal sensor and a first distal sensor arranged along the at least one fluid path section. Each of the first proximal sensor and the first distal sensor includes an emitter configured to emit light through the at least one fluid path section, and a detector configured to receive the light emitted through the at least one fluid path section and generate an electrical signal based on the received light. The fluid injector system further includes at least one processor programmed or configured to determine, based on a difference in the electrical signals generated by the first proximal sensor and the first distal sensor, at least one property of a content of the at least one fluid path section.
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公开(公告)号：US12011568B2
公开(公告)日：2024-06-18
申请号：US17372673
申请日：2021-07-12
Applicant: BAYER HEALTHCARE LLC
Inventor： Arthur Uber, III , Mark Trocki
CPC classification number: A61M5/172 , A61M5/007 , A61M5/16881 , A61N5/1002 , A61M2005/1406 , A61M5/14212 , A61M5/1452 , A61M5/16827 , A61M2039/242 , Y10T29/49826
Abstract: A high crack pressure valve is described. The high crack pressure valve includes an inlet adapted to receive a medical fluid pressurized by a pump; an outlet in fluid communication with a fluid path element, wherein the fluid path element is in fluid communication with downstream system components of a fluid delivery system; and a moveable element having a crack pressure threshold. The moveable element has a first closed position and a second open position and is configured to move from the first closed position to the second open position when a fluid pressure at the inlet is greater than or equal to the crack pressure threshold. The pressure of fluid at the outlet of the high crack pressure valve has little or no effect on movement of the moveable element from the first closed position to the second open position. Fluid injector systems and fluid path elements which include the high crack pressure valve are also described.
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公开(公告)号：US11998718B2
公开(公告)日：2024-06-04
申请号：US17999592
申请日：2021-06-16
Applicant: BAYER HEALTHCARE LLC
Inventor： Kevin Cowan , James Dedig , Shahab Taheri , Abhinav Srivastava , Barry Tucker , Michael Swantner , Christopher Capone , Jaroslow Wlodarczyk , Andrew Osan
CPC classification number: A61M5/14546 , A61M5/31515 , A61M5/365 , A61M2005/14553
Abstract: A plunger for use with a syringe includes a plunger body defining a central longitudinal axis and having a proximal end, a distal end, and a circumferential sidewall connecting the proximal end and the distal end. The plunger further includes at least one retaining member associated with and extending proximally from the plunger body. The at least one retaining member has a first end connected to the plunger body, a second end proximal to the first end and radially and resiliently deflectable relative to the first end, and at least one catch on the second end. A fluid injector system includes a piston having a plunger engagement mechanism configured for interacting with the at least one retaining element of the plunger to releasably engage the plunger for reciprocally driving the plunger within a barrel of the syringe.
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10.发明公开公开(公告)号：US20240156356A1
公开(公告)日：2024-05-16
申请号：US18391531
申请日：2023-12-20
Applicant: Bayer Healthcare LLC
Inventor： Johannes Anton Thüring , Arthur Uber, III , David Griffiths , Michael McDermott , Charles Lang , Linda Van Roosmalen , Barry Skirble , Adam Czibur , Daniel Moore , Vincenzo Caruso , Brandon Clarke
IPC: A61B5/0205 , A61B5/00 , A61M5/00 , A61M5/172
CPC classification number: A61B5/0205 , A61B5/4848 , A61B5/7275 , A61M5/007 , A61M5/1723 , A61B5/296
Abstract: A system and method for promoting and safeguarding the wellbeing of patients in relation to a fluid injection may obtain patient data; determine, based on the patient data, an initial risk prediction for a patient for a fluid injection to be administered to the patient, the initial risk prediction including a probability that the patient experiences at least one adverse event in response to the fluid injection; provide, to a user device, before the fluid injection is administered to the patient, the initial risk prediction; determine, after the fluid injection is started, sensor data associated with the patient; determine, based on the sensor data determined after the fluid injection is started, a current risk prediction including a probability that the patient experiences the at least one adverse event in response to the fluid injection; and provide, to the user device, the current risk prediction.
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