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公开(公告)号：US07094566B2
公开(公告)日：2006-08-22
申请号：US09810927
申请日：2001-03-16
申请人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0368 , A61K38/00 , A61K49/0008 , C07K14/7155 , C12N15/8509 , G01N33/6863 , G01N2500/00 , Y10S435/81
摘要： The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.
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公开(公告)号：US07071317B2
公开(公告)日：2006-07-04
申请号：US10348167
申请日：2003-01-22
IPC分类号： C12N15/12
CPC分类号： A61K38/57 , C07K14/8146
摘要： The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.
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3.发明授权Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods 失效组织金属蛋白酶抑制剂三（TIMP-3）的组成和方法公开(公告)号：US06683155B1
公开(公告)日：2004-01-27
申请号：US08728160
申请日：1996-10-09
IPC分类号： C07K100
CPC分类号： A61K38/57 , C07K14/8146
摘要： The present invention reveals a class of novel inhibitors of metalloproteinase. For convenience, these polypeptides are referred to as “TIMP-3”, as these polypeptides represent a new class of members of the tissue inhibitors of metalloproteinases. Also provided are DNA sequences coding for all or part of the TIMP-3s, vectors containing such DNA sequences, and host cells transformed or transfected with such vectors. In addition, methods of producing recombinant TIMP-3s, methods of treating disorders, pharmaceutical compositions including TIMP-3s and antibodies selectively binding TIMP-3s are provided.
摘要翻译： 本发明揭示了一类新的金属蛋白酶抑制剂。 为方便起见，这些多肽被称为“TIMP-3”，因为这些多肽代表金属蛋白酶组织抑制剂的新一类成员。 还提供了编码全部或部分TIMP-3的DNA序列，含有此类DNA序列的载体，以及用这些载体转化或转染的宿主细胞。 另外，提供了生产重组TIMP-3的方法，治疗病症的方法，包括TIMP-3的药物组合物和选择性结合TIMP-3的抗体。
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公开(公告)号：US07842788B2
公开(公告)日：2010-11-30
申请号：US12284131
申请日：2008-09-18
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C07K16/38
CPC分类号： A61K38/57 , C07K14/8146
摘要： The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.
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5.发明申请Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods 失效组织金属蛋白酶抑制剂三（TIMP-3）的组成和方法公开(公告)号：US20100010201A1
公开(公告)日：2010-01-14
申请号：US12284131
申请日：2008-09-18
IPC分类号： C07K16/18
CPC分类号： A61K38/57 , C07K14/8146
摘要： The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.
摘要翻译： 本发明一般涉及金属蛋白酶抑制剂和编码这种抑制剂的多核苷酸。 特别地，本发明涉及被称为三型或TIMP-3的金属蛋白酶的新型哺乳动物抑制剂的片段，衍生物和类似物，以及编码其的多核苷酸。 还提供了生产这种组合物的新方法和使用这些组合物的新方法。
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公开(公告)号：US20110160438A1
公开(公告)日：2011-06-30
申请号：US12914873
申请日：2010-10-28
申请人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
IPC分类号： C07K16/28
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0368 , A61K38/00 , A61K49/0008 , C07K14/7155 , C12N15/8509 , G01N33/6863 , G01N2500/00 , Y10S435/81
摘要： The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.
摘要翻译： 本发明提供IL-17受体样多肽和编码该多肽的核酸分子。 本发明还提供载体，宿主细胞，激动剂和拮抗剂（包括选择性结合剂）以及用于产生IL-17受体样多肽的方法。 还提供用于治疗，诊断，改善或预防具有IL-17受体样多肽的疾病的方法。
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公开(公告)号：US20090281287A1
公开(公告)日：2009-11-12
申请号：US12455553
申请日：2009-06-03
申请人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
IPC分类号： C07K19/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0368 , A61K38/00 , A61K49/0008 , C07K14/7155 , C12N15/8509 , G01N33/6863 , G01N2500/00 , Y10S435/81
摘要： The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.
摘要翻译： 本发明提供IL-17受体样多肽和编码该多肽的核酸分子。 本发明还提供载体，宿主细胞，激动剂和拮抗剂（包括选择性结合剂）以及用于产生IL-17受体样多肽的方法。 还提供用于治疗，诊断，改善或预防具有IL-17受体样多肽的疾病的方法。
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公开(公告)号：US06562596B1
公开(公告)日：2003-05-13
申请号：US08134231
申请日：1993-10-06
IPC分类号： C12P2102
CPC分类号： A61K38/57 , C07K14/8146
摘要： The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.
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9.发明授权Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods 失效组织金属蛋白酶抑制剂三（TIMP-3）的组成和方法公开(公告)号：US07435719B2
公开(公告)日：2008-10-14
申请号：US11429123
申请日：2006-05-04
IPC分类号： A61K38/00
CPC分类号： A61K38/57 , C07K14/8146
摘要： The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.
摘要翻译： 本发明一般涉及金属蛋白酶抑制剂和编码这种抑制剂的多核苷酸。 特别地，本发明涉及被称为三型或TIMP-3的金属蛋白酶的新型哺乳动物抑制剂的片段，衍生物和类似物，以及编码其的多核苷酸。 还提供了生产这种组合物的新方法和使用这些组合物的新方法。
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