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公开(公告)号：US20110160438A1
公开(公告)日：2011-06-30
申请号：US12914873
申请日：2010-10-28
申请人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
IPC分类号： C07K16/28
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0368 , A61K38/00 , A61K49/0008 , C07K14/7155 , C12N15/8509 , G01N33/6863 , G01N2500/00 , Y10S435/81
摘要： The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.
摘要翻译： 本发明提供IL-17受体样多肽和编码该多肽的核酸分子。 本发明还提供载体，宿主细胞，激动剂和拮抗剂（包括选择性结合剂）以及用于产生IL-17受体样多肽的方法。 还提供用于治疗，诊断，改善或预防具有IL-17受体样多肽的疾病的方法。
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公开(公告)号：US20090281287A1
公开(公告)日：2009-11-12
申请号：US12455553
申请日：2009-06-03
申请人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
IPC分类号： C07K19/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0368 , A61K38/00 , A61K49/0008 , C07K14/7155 , C12N15/8509 , G01N33/6863 , G01N2500/00 , Y10S435/81
摘要： The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.
摘要翻译： 本发明提供IL-17受体样多肽和编码该多肽的核酸分子。 本发明还提供载体，宿主细胞，激动剂和拮抗剂（包括选择性结合剂）以及用于产生IL-17受体样多肽的方法。 还提供用于治疗，诊断，改善或预防具有IL-17受体样多肽的疾病的方法。
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公开(公告)号：US20050074427A1
公开(公告)日：2005-04-07
申请号：US10855810
申请日：2004-05-27
申请人： Eugene Medlock , Richard Yeh , Scott Silbiger , Gary Elliott , Hung Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott Silbiger , Gary Elliott , Hung Nguyen , Shuqian Jing
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P29/00 , A61P31/00 , A61P37/04 , A61P43/00 , C07K14/54 , C07K14/715 , C07K16/24 , C07K17/08 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/68 , A61K38/20 , C07H21/04
CPC分类号： A61K39/3955 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0381 , A01K2267/0387 , A61K38/20 , A61K48/00 , C07K14/54 , C07K14/7155 , C07K2319/00 , C07K2319/30 , C12N15/8509
摘要： Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 like polypeptides, agonists, or antagonists thereof.
摘要翻译： 新型IL-17样多肽和编码相同的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂和用于产生IL-17样多肽的方法。 还提供用于治疗，诊断，改善或预防具有IL-17类似多肽，激动剂或其拮抗剂的疾病的方法。
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公开(公告)号：US20050048029A1
公开(公告)日：2005-03-03
申请号：US10870711
申请日：2004-06-17
申请人： Eugene Medlock , Richard Yeh , Scott Silbiger , Gary Elliott , Hung Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott Silbiger , Gary Elliott , Hung Nguyen , Shuqian Jing
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P29/00 , A61P31/00 , A61P37/04 , A61P43/00 , C07K14/54 , C07K14/715 , C07K16/24 , C07K17/08 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/68 , A61K38/20
CPC分类号： A61K39/3955 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0381 , A01K2267/0387 , A61K38/20 , A61K48/00 , C07K14/54 , C07K14/7155 , C07K2319/00 , C07K2319/30 , C12N15/8509
摘要： Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 like polypeptides, agonists, or antagonists thereof.
摘要翻译： 新型IL-17样多肽和编码相同的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂和用于产生IL-17样多肽的方法。 还提供用于治疗，诊断，改善或预防具有IL-17类似多肽，激动剂或其拮抗剂的疾病的方法。
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公开(公告)号：US07094566B2
公开(公告)日：2006-08-22
申请号：US09810927
申请日：2001-03-16
申请人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0368 , A61K38/00 , A61K49/0008 , C07K14/7155 , C12N15/8509 , G01N33/6863 , G01N2500/00 , Y10S435/81
摘要： The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.
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公开(公告)号：US20100303820A1
公开(公告)日：2010-12-02
申请号：US12787295
申请日：2010-05-25
申请人： Eugene Medlock , Richard Yeh , Scott Michael Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott Michael Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
IPC分类号： A61K39/395 , A61P11/00
CPC分类号： A61K39/3955 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0381 , A01K2267/0387 , A61K38/20 , A61K48/00 , C07K14/54 , C07K14/7155 , C07K2319/00 , C07K2319/30 , C12N15/8509
摘要： Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 like polypeptides, agonists, or antagonists thereof.
摘要翻译： 新型IL-17样多肽和编码相同的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂和用于产生IL-17样多肽的方法。 还提供用于治疗，诊断，改善或预防具有IL-17类似多肽，激动剂或其拮抗剂的疾病的方法。
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7.发明授权Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 有权人抗OPGL中和抗体作为选择性OPGL途径抑制剂公开(公告)号：US08455629B2
公开(公告)日：2013-06-04
申请号：US13360454
申请日：2012-01-27
申请人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
发明人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.
摘要翻译： 提供了与骨保护素配体（OPGL）相互作用的单克隆抗体和产生它们的杂交瘤。 还提供了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。 进一步提供使用OPGL抗体检测样品中OPGL量的方法。
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8.发明申请Human Anti-OPGL Neutralizing Antibodies As Selective OPGL Pathway Inhibitors 有权人抗OPGL中和抗体作为选择性OPGL途径抑制剂公开(公告)号：US20120156725A1
公开(公告)日：2012-06-21
申请号：US13360454
申请日：2012-01-27
申请人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
发明人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.
摘要翻译： 提供了与骨保护素配体（OPGL）相互作用的单克隆抗体和产生它们的杂交瘤。 还提供了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。 进一步提供使用OPGL抗体检测样品中OPGL量的方法。
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9.发明申请Human Anti-OPGL Neutralizing Antibodies as Selective OPGL Pathway Inhibitors 有权人抗OPGL中和抗体作为选择性OPGL途径抑制剂公开(公告)号：US20110052604A1
公开(公告)日：2011-03-03
申请号：US12782376
申请日：2010-05-18
申请人： William J. Boyle , Eugene Medlock , John J. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
发明人： William J. Boyle , Eugene Medlock , John J. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
IPC分类号： A61K39/395 , A61P19/08 , A61P19/10
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.
摘要翻译： 提供了与骨保护素配体（OPGL）相互作用的单克隆抗体和产生它们的杂交瘤。 还提供了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。 进一步提供使用OPGL抗体检测样品中OPGL量的方法。
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10.发明申请Human Anti-OPGL Neutralizing Antibodies As Selective OPGL Pathway Inhibitors 审中-公开人抗OPGL中和抗体作为选择性OPGL途径抑制剂公开(公告)号：US20100209435A1
公开(公告)日：2010-08-19
申请号：US12705962
申请日：2010-02-15
申请人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
发明人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , A61P19/10 , A61P19/08
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.
摘要翻译： 提供了与骨保护素配体（OPGL）相互作用的单克隆抗体和产生它们的杂交瘤。 还提供了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。 进一步提供使用OPGL抗体检测样品中OPGL量的方法。
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