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    NOVEL HEMOGLOBIN-DERIVED PEPTIDE BASED PHARMACEUTICAL COMPOSITIONS
    21.
    发明申请
    NOVEL HEMOGLOBIN-DERIVED PEPTIDE BASED PHARMACEUTICAL COMPOSITIONS 审中-公开
    新型HEMOGLOBIN衍生的基于肽的药物组合物

    公开(公告)号：US20160184404A1

    公开(公告)日：2016-06-30

    申请号：US14783781

    申请日：2014-04-11

    申请人： CLINIQUE LA PRAIRIE

    发明人： Adrian HEINI ,  Ernst Theodor RIETSCHEL ,  Christian ALEXANDER ,  Klaus BRANDENBURG ,  Artur J. ULMER ,  Jean-Pierre MACH ,  Reginald M. GORCZYNSKI ,  Didier HEUMANN

    IPC分类号： A61K38/42 ,  C07K14/805 ,  A61K31/739

    CPC分类号： A61K38/42 ,  A61K31/739 ,  A61K45/06 ,  C07K14/805 ,  A61K2300/00

    摘要： The present invention relates to a pharmaceutical composition comprising at least one Toll-like receptor (TLR)-activating amphiphilic lipid and at least one hemoglobin-derived peptide and optionally a pharmaceutically acceptable carrier. The present invention also relates to the pharmaceutical composition according to the invention for use in preventing and/or treating tumours, preventing and/or treating infections, preventing and/or treating allergies, preventing and/or treating age-related immune imbalances, stimulating the innate and adaptive immune system and/or alleviating the adverse side effects of irradiation. Moreover, the present invention also relates to a hemoglobin-derived peptide as well as its use in treating a bacterial infection.

    摘要翻译： 本发明涉及包含至少一种Toll样受体（TLR）活化的两亲性脂质和至少一种血红蛋白衍生的肽以及任选的药学上可接受的载体的药物组合物。 本发明还涉及根据本发明的用于预防和/或治疗肿瘤，预防和/或治疗感染，预防和/或治疗过敏症，预防和/或治疗与年龄有关的免疫失衡的刺激药物组合物 先天性和适应性免疫系统和/或减轻照射的不良副作用。 此外，本发明还涉及血红蛋白衍生肽以及其在治疗细菌感染中的用途。

    Therapy-enhancing glucan
    23.
    发明授权
    Therapy-enhancing glucan 有权
    治疗增强型葡聚糖

    公开(公告)号：US09211304B2

    公开(公告)日：2015-12-15

    申请号：US13760307

    申请日：2013-02-06

    申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH ,  Biotec Pharmacon ASA

    发明人： Nai-Kong V. Cheung ,  Rolf Einar Engstad

    IPC分类号： A61K31/716 ,  C08B37/00 ,  A61K31/715 ,  A61K31/739 ,  A61K39/39 ,  A61K39/395 ,  A61K39/44 ,  A61K47/36 ,  A61K39/00

    CPC分类号： A61K39/39 ,  A61K31/715 ,  A61K31/716 ,  A61K31/739 ,  A61K39/39541 ,  A61K39/39558 ,  A61K39/44 ,  A61K47/36 ,  A61K2039/55583 ,  C08B37/0024 ,  A61K2300/00

    摘要： This invention provides a method for introducing substances into cells comprising contacting a composition comprising orally administered beta-glucan with said cells. This invention also provides a method for introducing substances into a subject comprising administering to the subject an effective amount of the above compositions. The substance which could be delivered orally includes but is not limited to peptides, proteins, RNAs, DNAs, chemotherapeutic agents, biologically active agents, plasmids, and other small molecules and compounds. Finally, this invention provides a composition comprising orally administered beta-glucan capable of enhancing efficacy of IgM and different uses of the said composition.

    摘要翻译： 本发明提供了将物质引入细胞的方法，包括使包含口服β-葡聚糖的组合物与所述细胞接触。 本发明还提供了将物质引入受试者的方法，包括向受试者施用有效量的上述组合物。 可以口服递送的物质包括但不限于肽，蛋白质，RNA，DNA，化学治疗剂，生物活性剂，质粒和其他小分子和化合物。 最后，本发明提供一种组合物，其包含能够增强IgM的功效和所述组合物的不同用途的口服β-葡聚糖。

    REMEDY
    25.
    发明申请
    REMEDY 审中-公开
    补救

    公开(公告)号：US20140206641A1

    公开(公告)日：2014-07-24

    申请号：US14221606

    申请日：2014-03-21

    申请人： Hiroshi Terada

    发明人： Hiroshi Terada ,  Kimiko Makino ,  Gen-Ichiro Soma

    IPC分类号： A61K31/739 ,  A61K35/74

    CPC分类号： A61K31/739 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/50 ,  A61K31/00 ,  A61K31/496 ,  A61K35/74 ,  A61K45/06 ,  Y02A50/411 ,  A61K2300/00

    摘要： It is intended to provide a remedy for diseases caused by macrophages with dysfunction or mediated by macrophages. Namely, a remedy which activates the phagocytic capacity of macrophages and thus is efficiently incorporated into the macrophages due to the vigorous phagocytosis. As a result, the macrophages with dysfunction are normalized, macrophages infected with a pathogen are exterminated or a pathogen in the infected macrophages is exterminated.

    摘要翻译： 旨在为由功能障碍或由巨噬细胞介导的巨噬细胞引起的疾病提供补救。 即，由于剧烈的吞噬作用，能够激活巨噬细胞的吞噬能力，​​从而有效地并入巨噬细胞。 结果，具有功能障碍的巨噬细胞被归一化，被病原体感染的巨噬细胞被灭绝或被感染的巨噬细胞中的病原体被灭绝。

    LIPOPOLYSACCHARIDE ISOLATED FROM PYRULARIA TISSUE AND/OR PYRULARIA-ASSOCIATED BACTERIA AND USES THEREOF
    28.
    发明申请
    LIPOPOLYSACCHARIDE ISOLATED FROM PYRULARIA TISSUE AND/OR PYRULARIA-ASSOCIATED BACTERIA AND USES THEREOF 审中-公开
    从PYRULARIA组织和/或PYRULARIA相关细菌分离的脂多糖和其用途

    公开(公告)号：US20110070269A1

    公开(公告)日：2011-03-24

    申请号：US12890502

    申请日：2010-09-24

    申请人： STEVEN G. WOOD ,  KATIE SOUTHWICK ,  L. DEE NORD

    发明人： STEVEN G. WOOD ,  KATIE SOUTHWICK ,  L. DEE NORD

    IPC分类号： A61K39/00 ,  C07H15/06 ,  A61K31/739 ,  A61K38/19 ,  A61P35/00

    CPC分类号： A61K38/191 ,  A61K36/185 ,  A61K38/193 ,  A61K38/2006 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/204 ,  A61K38/2066 ,  A61K38/2086 ,  A61K38/21 ,  A61K2300/00

    摘要： This disclosure provides, in certain embodiments, methods for generating and using extracts of Pyrularia (e.g., Pyrularia pubera) and/or epiphytic/endophytic bacteria associated therewith, either alone or in combination with conventional immunostimulant(s) or anti-inflammatory agents, for modulation of the immune system of a subject. Also provided are compositions that include specific Pyrularia extracts, bacteria isolated from Pyrularia tissue (in particular, Pantoea species), and extracts of from such bacteria. Also provided herein are purified components of Pyrularia extracts and/or extracts from the epiphytic/endophytic bacteria, which extracts exhibit mitogenic or cytotoxic activities. Compositions provided herein can be used for the treatment of neutropenia subsequent to chemotherapy, and for the treatment of immune deficiency (e.g., such as is caused by toxic chemotherapy, disease, or advancing age), as well as in other immune-stimulatory methods. Other embodiments of the invention provide methods of producing extracts of the invention, as well as purified bioactive components thereof, including particularly bacterial LPS.

    摘要翻译： 本公开在某些实施方案中提供了单独或与常规免疫刺激剂或抗炎剂组合产生和使用与其相关的Pyrularia（例如，Pyrularia pubera）和/或附生/内生细菌的提取物的方法，用于 调节受试者的免疫系统。 还提供了包括特定的Pyrularia提取物，从Pyrularia组织（特别是Pantoea物种）分离的细菌和来自这些细菌的提取物的组合物。 本文还提供了来自附生/内生细菌的Pyrularia提取物和/或提取物的纯化组分，其提取物显示有丝分裂或细胞毒活性。 本文提供的组合物可用于治疗化疗后的中性粒细胞减少症，以及用于治疗免疫缺陷（例如由毒性化疗，疾病或进展年龄引起的），以及其它免疫刺激方法。 本发明的其它实施方案提供了生产本发明提取物的方法，以及其纯化的生物活性成分，特别是细菌LPS。