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    NOVEL MALARIA VACCINE
    1.
    发明申请
    NOVEL MALARIA VACCINE 审中-公开
    新鲜疟疾疫苗

    公开(公告)号：US20150037365A1

    公开(公告)日：2015-02-05

    申请号：US14325696

    申请日：2014-07-08

    申请人： OSAKA UNIVERSITY

    发明人： Toshihiro HORII ,  Ken ISHII ,  Takahiro TOUGAN

    IPC分类号： A61K39/015 ,  A61K39/39 ,  C07K14/445

    CPC分类号： A61K39/015 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/55561 ,  C07K14/445 ,  Y02A50/412 ,  Y10S530/822

    摘要： The present invention provides a vaccine for preventing and/or treating Plasmodium falciparum infections, which comprises a polypeptide set forth in SEQ ID NO: 1 or represented by formula (1), and an adjuvant. X1-A-B-X2-Y-X3-(Y)n-X4-(Y)n-X5  (1) (In the formula, X1 represents the 1st to 7th amino acid residues in a polypeptide set forth in SEQ ID NO: 1; X2 represents the 73th to 177th amino acid residues; X3 represents the 178th to 258th amino acid residues; X4 represents the 259th to 289th amino acid residues; X5 represents the 290th to 334th amino acid residues; A represents an 8-mer repeat sequence contained in a 47-kd region of SERA polypeptide of Plasmodium falciparum; B represents a sequence of a serine-rich region contained in a 47-kd region of SERA polypeptide of Plasmodium falciparum; Y represents any one selected from A-A, A-B, and B; and n is an integer of 0 or 1.)

    摘要翻译： 本发明提供了用于预防和/或治疗恶性疟原虫感染的疫苗，其包含SEQ ID NO：1所示或由式（1）表示的多肽和佐剂。 X1-AB-X2-Y-X3-（Y）n-X4-（Y）n-X5（1）（式中X1表示SEQ ID NO：1中所示多肽中的第1至第7个氨基酸残基。 1; X2代表第73位至第177位氨基酸残基; X3代表第178位至第258位氨基酸残基; X4代表第259位至第289位氨基酸残基; X5代表第290位至第334位氨基酸残基; A代表8聚体重复序列 包含在恶性疟原虫的SERA多肽的47-kd区域中; B表示恶性疟原虫的SERA多肽的47kd区域中含有的丝氨酸丰富区域的序列; Y表示选自AA，AB，B ; n为0或1的整数）

    Lytic peptide prodrugs
    4.
    发明授权
    Lytic peptide prodrugs 有权
    裂解肽前药

    公开(公告)号：US07456146B2

    公开(公告)日：2008-11-25

    申请号：US09938623

    申请日：2001-08-27

    申请人： Xianxhang Yu ,  Thomas E. Wagner

    发明人： Xianxhang Yu ,  Thomas E. Wagner

    IPC分类号： A61K38/16 ,  A61K38/33 ,  A61K45/00 ,  C07K14/195 ,  C07K14/435

    CPC分类号： C07K16/18 ,  A61K47/65 ,  Y10S530/82 ,  Y10S530/822 ,  Y10S530/825

    摘要： A cytotoxin can be rendered non-toxic by charge neutralizing the amino acids salient to pore assembly and/or sterically inhibiting formation of the peptide's active conformation. In the presence of specific proteases, the inactive peptide or procytotoxin can be activated to assemble into its lytic conformation and selectively destroy a target cell.

    摘要翻译： 细胞毒素可以通过电荷中和纳米孔组装氨基酸和/或空间抑制肽的活性构象的形成而变得无毒。 在特定蛋白酶的存在下，可以活化无活性肽或原细胞毒素以组装成其裂解构象并选择性地破坏靶细胞。

    Reagent and method for detecting a Cryptosporidium parvum sporozoite antigen
    5.
    发明授权
    Reagent and method for detecting a Cryptosporidium parvum sporozoite antigen 失效
    用于检测隐孢子虫子孢子抗原的试剂和方法

    公开(公告)号：US07410771B2

    公开(公告)日：2008-08-12

    申请号：US11404405

    申请日：2006-04-14

    申请人： Victor C. W. Tsang ,  Jeffrey L. Call ,  Yeuk-mui Lee ,  Kathy Hancock

    发明人： Victor C. W. Tsang ,  Jeffrey L. Call ,  Yeuk-mui Lee ,  Kathy Hancock

    IPC分类号： G01N33/53

    CPC分类号： C07K16/20 ,  A61K2039/505 ,  Y10S530/822 ,  Y10S530/864

    摘要： A reagent and method for the specific and highly sensitive detection of C. parvum in which the reagent is an antibody for a soluble C. parvum sporozoite antigen and the method is an immunoassay in which the antibody is used to detect or quantify C. parvum sporozoite antigen in a sample. The sample is treated to cause excystation of C. parvum oocytes, thereby releasing a C. parvum sporozoite antigen, and combined with antibodies specific for the sporozoite antigen under conditions to form an antibody-antigen complex. Detection of the complex indicates the presence of C. parvum in the sample. The assay allows recognition and detection of C. parvum in turbid samples, and due to a lack of crossreactivity with other Cryptosporidium species, is specific for C. parvum contamination or infection. The assay is highly sensitive, allowing for the detection of less than 100 oocysts per milliliter of sample.

    摘要翻译： 用于特异性和高度敏感检测小曲霉的试剂和方法，其中试剂是可溶性​​小孢子虫子孢子抗原的抗体，并且该方法是免疫测定法，其中该抗体用于检测或定量小孢子虫子孢子 抗原。 对样品进行处理以引起小孢子虫卵母细胞的排泄，从而释放小孢子虫子孢子抗原，并且在形成抗体 - 抗原复合物的条件下与子孢子抗原特异性抗体结合。 复合物的检测表明样品中存在小白菜。 该测定允许在混浊样品中识别和检测小白菜，并且由于与其他隐孢子虫属物种的交叉反应性不足，对小孢子虫污染或感染是特异性的。 该测定法是高度敏感的，允许每毫升样品检测少于100个卵囊。

    Gene encoding protein from merozoite of Babesia caballi, recombinant protein obtained with said gene and use thereof
    6.
    发明授权
    Gene encoding protein from merozoite of Babesia caballi, recombinant protein obtained with said gene and use thereof 失效
    来自Babesia caballi的裂殖子的基因编码蛋白，用该基因获得的重组蛋白及其用途

    公开(公告)号：US07326543B2

    公开(公告)日：2008-02-05

    申请号：US10863338

    申请日：2004-06-09

    申请人： Hiromi Ikadai ,  Ikuo Igarashi ,  Naoyoshi Suzuki ,  Hideyuki Nagasawa ,  Kozo Fujisaki ,  Takeshi Mikami

    发明人： Hiromi Ikadai ,  Ikuo Igarashi ,  Naoyoshi Suzuki ,  Hideyuki Nagasawa ,  Kozo Fujisaki ,  Takeshi Mikami

    IPC分类号： C12N15/09 ,  C12P21/04 ,  A61K39/002 ,  A61K39/015 ,  C07K1/00

    CPC分类号： G01N33/56905 ,  C07K14/44 ,  C07K16/20 ,  Y10S530/822

    摘要： The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In accordance with the present invention, it is possible to stably prepare the 48 kDa protein of rhoptry of Babesia caballi and the gene encoding said protein in a large amount with the recombinant DNA technique. The present invention also provides a method for diagnosing equine babesiasis which comprises either specifically detecting anti-Babesia caballi antibody present in equine blood by using the recombinant protein of present invention as an antigen or detecting the presence of Babesia caballi merozoite in equine blood by using the antibody of the present invention.

    摘要翻译： 本发明提供了编码来自巴贝虫（Babesia caballi）的重组蛋白的巴贝虫（Babesia caballi）的裂殖子的蛋白质和能够特异性结合巴贝虫裂殖子的48kDa蛋白质的抗体的基因。 根据本发明，可以通过重组DNA技术稳定地制备巴贝氏菌的48kDa蛋白质和大量编码所述蛋白质的基因。 本发明还提供了一种用于诊断马贝氏病的方法，其特征在于，通过使用本发明的重组蛋白作为抗原或者通过使用本发明的马血中的巴贝虫突变体的存在来特异性检测马血中存在的抗巴贝虫抗体 本发明的抗体。

    Malarial pre-erythrocytic stage polypeptide molecules
    8.
    发明授权
    Malarial pre-erythrocytic stage polypeptide molecules 失效
    疟疾前红细胞阶段多肽分子

    公开(公告)号：US07056518B2

    公开(公告)日：2006-06-06

    申请号：US09742096

    申请日：2000-12-22

    申请人： Pierre Druilhe ,  Pierre Daubersies

    发明人： Pierre Druilhe ,  Pierre Daubersies

    IPC分类号： A61K39/015 ,  C07K14/445 ,  C01N33/569

    CPC分类号： A61K39/015 ,  A61K39/00 ,  A61K39/385 ,  A61K2039/6018 ,  C07K14/445 ,  C07K16/205 ,  C07K2319/00 ,  Y02A50/412 ,  Y10S530/822

    摘要： Polypeptide molecules containing at least 10 consecutive amino acids of the amino acid sequence shown in FIG. 2, representing the LSA3 antigen, the following peptides being excluded: RDELFNELLNSVDVNGEVKENILEESQVNDDIFNSLVKSVQQEQQHNVEE VEESVEENDEESVEENVEENVENNDDGSVASSVEESIASSVDESIDSSIE- ENVAPTVEEIVAPTVEEIVAPSVVEKCAPSVEESVAPSVEESVAEMLKER (729S) RDELFNELLNSVDVNGEVKENILEESQVNDDIFNSLVKSVQQEQQHN DELFNELLNSVDVNGEVKENILEESQ, (NRI) LEESQVNDDIFSNSLVKSVQQEQQHNV, (NRII) VESVAPSVEESVAPSVEESVAENVESSV. (729RE)

    摘要翻译： 包含氨基酸序列的至少10个连续氨基酸的多肽分子，如图所示。 2 ，代表LSA3抗原，排除以下肽：

    TBODY VALIGN =“TOP”> RDELFNELLNSVDVNGEVKENILEESQVNDDIFNSLVKSVQQEQQHNVEE VEESVEENDEESVEENVEENVENNDDGSVASSVEESIASSVDESIDSSIE - ROW> ENVAPTVEEIVAPTVEEIVAPSVVEKCAPSVEESVAPSVEESVAEMLKER （729S） RDELFNELLNSVDVNGEVKENILEESQVNDDIFNSLVKSVQQEQQHN DELFNELLNSVDVNGEVKENILEESQ NRI） LEESQVNDDIFSNSLVKSVQQEQQHNV，（NRII） / ENTRY> VESVAPSVEESVAPSVEE SVAENVESSV。 （729RE）