公开(公告)号：US20050267031A1

公开(公告)日：2005-12-01

申请号：US11123182

申请日：2005-05-06

Applicant: Xianzhong Yu ,  Thomes Wagner

Inventor： Xianzhong Yu ,  Thomes Wagner

IPC: A61K38/00 ,  A61K39/00 ,  A61K47/48 ,  C07K14/435 ,  C07K14/44 ,  C07K16/18 ,  A61K38/16 ,  C07K14/195

CPC classification number: C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K47/65 ,  C07K14/43563 ,  C07K14/43572 ,  C07K16/18 ,  Y02A50/472 ,  Y10S530/82 ,  Y10S530/822 ,  Y10S530/823 ,  Y10S530/825

Abstract: A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group. These agents are useful in treating cancer, especially prostate cancer.

Abstract translation: 一类原细胞毒素的特征在于具有靶细胞特异性的杀死能力。 这样的一个方面可以是通过ε氨基具有至少一个被氨基酸残基的肽连接修饰的赖氨酸残基的成孔蛋白质。 这些药剂可用于治疗癌症，特别是前列腺癌。

公开(公告)号：US20090117658A1

公开(公告)日：2009-05-07

申请号：US12149097

申请日：2008-04-25

Applicant: Thomas E. Wagner ,  Gunter Schwamberger ,  Xianzhong Yu

Inventor： Thomas E. Wagner ,  Gunter Schwamberger ,  Xianzhong Yu

IPC: C12N15/86 ,  C12N15/06 ,  C12N15/64

CPC classification number: A61K47/6927 ,  A61K47/61 ,  A61K47/6901 ,  C12N2799/022 ,  C12N2810/10

Abstract: Described are a method and a composition for transfecting monocytes, as well as use of the same for therapeutic purposes. The composition is composed of a nucleic acid component, a lysosome evading component and a digestible particle that can be phagocytized. Preferably, the monocyte is a macrophage and the digestible particle is from a natural source, such as from a microbial source. More preferably, the digestible particle is a yeast cell wall particle such as zymosan. The composition itself, or cells pretreated with the composition, are useful in all gene medicine applications, such as gene therapy, gene vaccination, cancer treatment as well as immunomodulation and tissue repair.

Abstract translation: 描述了用于转染单核细胞的方法和组合物，以及将其用于治疗目的。 该组合物由核酸组分，溶酶体逃避组分和可以吞噬的可消化颗粒组成。 优选地，单核细胞是巨噬细胞，并且可消化颗粒来自天然来源，例如来自微生物来源。 更优选地，可消化颗粒是酵母细胞壁颗粒如酵母聚糖。 组合物本身或用组合物预处理的细胞可用于所有基因医学应用，例如基因治疗，基因疫苗接种，癌症治疗以及免疫调节和组织修复。

公开(公告)号：US07425535B2

公开(公告)日：2008-09-16

申请号：US11123182

申请日：2005-05-06

Applicant: Xianzhong Yu ,  Thomas E. Wagner

Inventor： Xianzhong Yu ,  Thomas E. Wagner

IPC: A61K38/16 ,  A61K38/33 ,  A61K45/00 ,  C07K14/195 ,  C07K14/435

CPC classification number: C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K47/65 ,  C07K14/43563 ,  C07K14/43572 ,  C07K16/18 ,  Y02A50/472 ,  Y10S530/82 ,  Y10S530/822 ,  Y10S530/823 ,  Y10S530/825

Abstract: A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group. These agents are useful in treating cancer, especially prostate cancer.

Abstract translation: 一类原细胞毒素的特征在于具有靶细胞特异性的杀死能力。 这样的一个方面可以是通过ε氨基具有至少一个被氨基酸残基的肽连接修饰的赖氨酸残基的成孔蛋白质。 这些药剂可用于治疗癌症，特别是前列腺癌。

公开(公告)号：US20090081789A1

公开(公告)日：2009-03-26

申请号：US12149086

申请日：2008-04-25

Applicant: Thomas E. Wagner ,  Gunter Schwamberger ,  Xianzhong Yu ,  Yanzhang Wei

Inventor： Thomas E. Wagner ,  Gunter Schwamberger ,  Xianzhong Yu ,  Yanzhang Wei

IPC: C12N5/02

CPC classification number: C12N15/113 ,  A61K47/6901 ,  A61K47/6923 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/53 ,  C12N2799/022

Abstract: The present invention describes a method for targeting a tumor cell comprising contacting the tumor cell with a composition comprising a macrophage and a factor that upregulates nuclear factor-kappa B (NFκB) activity.

Abstract translation: 本发明描述了靶向肿瘤细胞的方法，包括使肿瘤细胞与包含巨噬细胞的组合物和上调核因子κB（NFκB）活性的因子接触。

公开(公告)号：US07550426B2

公开(公告)日：2009-06-23

申请号：US11131443

申请日：2005-05-18

Applicant: Thomas E. Wagner ,  Xianzhong Yu

Inventor： Thomas E. Wagner ,  Xianzhong Yu

IPC: A61K38/16 ,  A61K38/33 ,  A61K45/00 ,  C07K14/195 ,  C07K14/435

CPC classification number: C07K14/195 ,  A61K38/00 ,  C07K14/44 ,  Y02A50/471 ,  Y10S530/82 ,  Y10S530/822 ,  Y10S530/823 ,  Y10S530/825

Abstract: A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group, and an acetyl group. These agents are useful in treating cancer, especially prostate cancer.

Abstract translation: 一类原细胞毒素的特征在于具有靶细胞特异性的杀死能力。 这样的一个方面可以是具有至少一个赖氨酸残基的成孔蛋白，其通过与氨基酸残基的肽键经由ε氨基和乙酰基修饰。 这些药剂可用于治疗癌症，特别是前列腺癌。

公开(公告)号：US20060264364A1

公开(公告)日：2006-11-23

申请号：US11131443

申请日：2005-05-18

Applicant: Thomas Wagner ,  Xianzhong Yu

Inventor： Thomas Wagner ,  Xianzhong Yu

IPC: C07K14/16 ,  C07K14/195

CPC classification number: C07K14/195 ,  A61K38/00 ,  C07K14/44 ,  Y02A50/471 ,  Y10S530/82 ,  Y10S530/822 ,  Y10S530/823 ,  Y10S530/825

Abstract: A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group, and an acetyl group. These agents are useful in treating cancer, especially prostate cancer.