公开(公告)号：US08551761B2

公开(公告)日：2013-10-08

申请号：US13127240

申请日：2009-10-24

申请人： Jens Göhring ,  Stefan Heydenhauss ,  Friedrich Menges ,  Reiner Spolaczyk ,  Jana Lepschi

发明人： Jens Göhring ,  Stefan Heydenhauss ,  Friedrich Menges ,  Reiner Spolaczyk ,  Jana Lepschi

IPC分类号： C12M1/00 ,  C12M1/36 ,  C12M1/38 ,  C12M1/34 ,  C12M3/00 ,  G01N15/06 ,  G01N35/00 ,  G01N33/44

CPC分类号： C12Q1/686 ,  B01L3/502715 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2300/04 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2300/1827 ,  B01L2400/0481 ,  G01N21/0332 ,  G01N21/11 ,  G01N2021/0325 ,  G01N2021/6439 ,  G01N2201/062 ,  Y10T436/11 ,  Y10T436/143333

摘要： The cartridge according to the invention for analysing biological samples comprises: a reaction chamber and a biochip mounted in the reaction chamber, a filling nozzle connected so as to communicate with the reaction chamber, and a compensation chamber connected so as to communicate with the reaction chamber, wherein the reaction chamber, the compensation chamber and all lines connected thereto form a chamber sealed as far as the filling nozzle, wherein the filling nozzle forms a free passage to the reaction chamber from outside the cartridge, and a stopper is provided which fits positively and tightly in the filling nozzle in such a way that, when pressed in over a certain distance, fluid is displaced from the filling nozzle towards the reaction chamber.

摘要翻译： 根据本发明的用于分析生物样品的盒包括：反应室和安装在反应室中的生物芯片，连接成与反应室连通的填充喷嘴和连接成与反应室连通的补偿室 其中，所述反应室，所述补偿室和与其连接的所有管线形成密封到所述填充喷嘴的腔室，其中所述填充喷嘴从所述筒外部形成到所述反应室的自由通道， 并且以这样的方式紧密地在填充喷嘴中，当被压入一定距离时，流体从填充喷嘴朝向反应室移位。

公开(公告)号：US08160665B2

公开(公告)日：2012-04-17

申请号：US11675725

申请日：2007-02-16

申请人： Reinhold Mischler ,  Gerhard Werner

发明人： Reinhold Mischler ,  Gerhard Werner

IPC分类号： A61B5/1455

CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/157 ,  A61B5/681 ,  A61B5/685 ,  G01N21/11 ,  G01N21/552

摘要： A sensor is described for optically determining the concentration of an analyte in a body fluid. This sensor comprises a needle arrangement which has at least one hollow needle having a hollow space extending from the distal end to the proximal end, the distal end of which is suitable for lancing. The proximal end of the needle opens into a chamber in which liquid that enters through the distal end of the needle can be collected. A window which is at least partially permeable to infrared radiation is in direct contact with the chamber.

摘要翻译： 描述了用于光学确定体液中分析物浓度的传感器。 该传感器包括针布置，其具有至少一个中空针头，该中空针头具有从远端延伸到近端的中空空间，其远端适于穿刺。 针的近端通向腔室，在该腔室中可以收集通过针头远端进入的液体。 对红外辐射至少部分透过的窗口与腔室直接接触。

公开(公告)号：US07988916B2

公开(公告)日：2011-08-02

申请号：US10513918

申请日：2003-05-07

申请人： Ben Bremauer

发明人： Ben Bremauer

IPC分类号： G01N31/16

CPC分类号： G01N1/38 ,  B01F15/0217 ,  B01F15/0237 ,  B01F15/0279 ,  B01J19/0093 ,  B01J19/185 ,  B01J2219/00788 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00952 ,  B01J2219/00986 ,  C02F1/008 ,  C02F1/686 ,  C02F1/76 ,  C02F2103/023 ,  C02F2103/42 ,  C02F2209/00 ,  C02F2209/005 ,  G01F11/021 ,  G01N21/11 ,  G01N21/79 ,  G01N31/16 ,  G01N33/18

摘要： An apparatus and method for measuring a range of small volumes of fluids to a high degree of precision, said apparatus including: a) a single reaction chamber (20); b) a piston (30) operable within said chamber to selectively and precisely vary the internal volume of said chamber; c) a first inlet (41) to said chamber in communication with one or more fluid sources of which a portion of a first fluid of said one or more fluids is adapted to be drawn into said chamber; d) at least one further inlet (43) including a second inlet to said chamber in communication with one or more fluid sources of which a portion of a second fluid of said one or more fluids is adapted to be drawn into said chamber; and e) a sealable outlet (45), wherein said piston is adapted to progressive draw said portion of a second fluid into said chamber until either accurare metering of a volume of said first or second portion of fluid is achived or a reaction involving said first and second portions in said chamber (such as a titration reaction) is completed.

摘要翻译： 一种用于以高精度测量少量流体的范围的装置和方法，所述装置包括：a）单个反应室（20）; b）可在所述腔室内操作以选择性地且精确地改变所述腔室的内部体积的活塞（30） c）与一个或多个流体源连通的所述室的第一入口（41），所述一个或多个流体的第一流体的一部分适于被吸入所述室; d）至少一个另外的入口（43），其包括与所述一个或多个流体源连通的所述室的第二入口，所述一个或多个流体的一部分第二流体适于被吸入所述室中; 以及e）可密封的出口（45），其中所述活塞适于将所述第二流体的所述部分逐渐拉入所述室，直到所述第一或第二部分流体的体积的精确计量被测量，或者涉及所述第一 并且完成所述室中的第二部分（例如滴定反应）。

公开(公告)号：US07958771B2

公开(公告)日：2011-06-14

申请号：US12108430

申请日：2008-04-23

申请人： Thomas M. Rezachek

发明人： Thomas M. Rezachek

IPC分类号： G01N21/00

CPC分类号： G01N21/1702 ,  G01N21/11

摘要： Various embodiments of the application provide a photoacoustic sensor, which includes: a gas cell having an opening; a light source to generate a radiation to radiate sample gas within the gas cell; a detector to detect the sample gas within the gas cell, and to generate electrical signals in response to acoustic signals generated by pressure fluctuations of the radiated sample gas caused by the radiation; and an active valve having a speaker aligned with the opening of the gas cell. The speaker having a voice coil and a diaphragm attached to the voice coil. A control signal is applicable for the speaker to control access of the gas cell. During sampling, the control signal causes the voice coil of the speaker to repeatedly or constantly lift the diaphragm from contact with the opening of the gas cell to allow sample gas enter the gas cell. While during detecting, the spring force of the voice coil causes the diaphragm in tight contact with the opening of gas cell to seal the gas cell.

摘要翻译： 本申请的各种实施例提供一种光声传感器，其包括：具有开口的气室; 产生辐射以在气室内辐射样气的光源; 检测器，用于检测气体单元内的样品气体，并响应于由辐射引起的辐射样品气体的压力波动产生的声信号产生电信号; 以及具有与气室的开口对准的扬声器的主动阀。 扬声器具有音圈和附接到音圈的隔膜。 控制信号适用于扬声器以控制气室的通路。 在采样期间，控制信号使扬声器的音圈反复或不断地提升隔膜与气室的开口接触，以使样气进入气室。 在检测期间，音圈的弹力使得隔膜与气室的开口紧密接触以密封气室。

公开(公告)号：US20110056276A1

公开(公告)日：2011-03-10

申请号：US12556108

申请日：2009-09-09

申请人： Elijah L Scott ,  Scott D. Janson

发明人： Elijah L Scott ,  Scott D. Janson

IPC分类号： G01N1/44

CPC分类号： G01N21/15 ,  G01N21/05 ,  G01N21/11 ,  G01N21/51 ,  G01N21/534 ,  G01N21/8507 ,  G01N33/1886 ,  G01N2001/205 ,  G01N2021/0143 ,  G01N2201/0212 ,  G01N2201/0218

摘要： An anti-fouling submersible liquid sensor (100) is provided according to the invention. The anti-fouling submersible liquid sensor (100) includes a measurement chamber (102) including one or more liquid measurement sensors (121) and at least one chamber aperture (104), at least one gate (107), a gate actuator (128) configured to selectively move the at least one gate (107) between open and closed positions with regard to the at least one chamber aperture (104), and a radiation source (124) configured to inactivate at least a portion of a liquid sample in the measurement chamber (102). The anti-fouling submersible liquid sensor (100) is configured to admit the liquid sample into the measurement chamber (102), perform one or more measurements on the liquid sample, substantially inactivate biological material within the liquid sample with radiation from the radiation source (124), and hold the inactivated liquid sample until a next sample time.

摘要翻译： 根据本发明提供了一种防污潜水液体传感器（100）。 防污潜水液体传感器（100）包括包括一个或多个液体测量传感器（121）和至少一个腔室孔（104）的测量室（102），至少一个门（107），门致动器（128） ）构造成相对于所述至少一个室孔（104）选择性地将所述至少一个栅极（107）移动到打开位置和闭合位置之间，以及辐射源（124），其配置成使至少一部分液体样品在 测量室（102）。 防污潜水液体传感器（100）被配置为允许液体样品进入测量室（102），对液体样品执行一个或多个测量，基本上使来自辐射源的辐射使液体样品内的生物材料失活 124），并将灭活的液体样品保持在下一个采样时间。

公开(公告)号：US20100328654A1

公开(公告)日：2010-12-30

申请号：US12666814

申请日：2008-06-24

申请人： Coen Adrianus Verschuren ,  Albert Hendrik Jan Immink

发明人： Coen Adrianus Verschuren ,  Albert Hendrik Jan Immink

IPC分类号： G01N21/00

CPC分类号： G01N21/552 ,  G01N21/11 ,  G01N21/648

摘要： The application relates to a method and a microelectronic sensor device for making optical examinations in an investigation region (13) at the contact surface (12) of a carrier (10), wherein an input light beam (L1, L1′) is sent from a light source (20) towards the investigation region (13), and wherein an output light beam (L2, L2′) coming from the investigation region (13) is detected by a light detector (30). An evaluation unit (50) that is coupled to the light detector (30) is adapted to determine the wetting grade of the investigation region (13) based on a characteristic parameter of the output light beam (L2, L2′), e.g. its intensity. In a preferred embodiment, the evaluation unit (50) is adapted to determine a change in the light intensity caused by a liquid contacting the contact surface (12). The wetting grade may particularly be detected in a test region (14) that is located adjacent to the investigation region (13) and that has a higher roughness than the investigation region (13).

摘要翻译： 本申请涉及一种用于在载体（10）的接触表面（12）处的调查区域（13）中进行光学检查的方法和微电子传感器装置，其中输入光束（L1，L1'）从 朝向调查区域（13）的光源（20），并且其中来自调查区域（13）的输出光束（L2，L2'）由光检测器（30）检测。 耦合到光检测器（30）的评估单元（50）适于基于输出光束（L2，L2'）的特征参数来确定调查区域（13）的润湿等级。 其强度。 在优选实施例中，评估单元（50）适于确定由与接触表面（12）接触的液体引起的光强度的变化。 可以在与调查区域（13）相邻并且具有比调查区域（13）更高的粗糙度的测试区域（14）中特别地检测润湿等级。

公开(公告)号：US20100128266A1

公开(公告)日：2010-05-27

申请号：US12301834

申请日：2007-05-21

申请人： Hanno Wachernig ,  Achim Hogg

发明人： Hanno Wachernig ,  Achim Hogg

IPC分类号： G01N15/02 ,  G01N1/10

CPC分类号： G01N27/453 ,  G01N21/01 ,  G01N21/03 ,  G01N21/11 ,  G01N27/44721 ,  G01N27/44743 ,  G01N2021/0367 ,  G01N2021/052

摘要： With a measuring instrument for measuring sample particles moving in a cuvette, for example for measuring a zeta potential or the Brownian size the particles, with a filling device for filling and an emptying device for emptying the cuvette mounted on the ends thereof and with devices for irradiating and for monitoring the particles, it is problematical always to position the cuvette correctly or in a defined manner relative to the direction of radiation and to the monitoring device. To resolve this problem, it is proposed that the cuvette member is mounted by means of a cuvette bearing and the filling and the emptying device are fastened exclusively to the cuvette in such a way that the position of the cuvette relative to the surroundings thereof is determined and defined exclusively by the cuvette bearing.

摘要翻译： 使用用于测量在比色皿中移动的样品颗粒的测量仪器，例如用于测量ζ电位或布朗尺寸的颗粒，具有用于填充的填充装置和用于排空安装在其端部上的反应杯的排空装置，以及用于 照射和监测颗粒，总是将试管正确地或以相对于辐射方向的限定方式定位到监测装置是有问题的。 为了解决这个问题，提出了通过比色皿轴承安装比色皿构件，并且填充物和排空装置被专门地紧固到比色皿上，使得比色皿相对于其周围的位置被确定 并由比色皿轴承专门定义。

公开(公告)号：US20090232707A1

公开(公告)日：2009-09-17

申请号：US12075512

申请日：2008-03-11

申请人： Holger Behnk

发明人： Holger Behnk

IPC分类号： B01L3/00

CPC分类号： B01F13/0818 ,  B01L3/5025 ,  B01L2300/0809 ,  B01L2300/087 ,  B01L2400/0457 ,  G01N21/11 ,  G01N2021/0328

摘要： The apparatus for examining bodily fluids comprising a plurality of cuvettes into which bodily fluid and a reagent can be introduced is distinguished by the apparatus comprising chambers that are open at the top, the number of said chambers being at least equal to the number of the cuvettes.

摘要翻译： 用于检查包括可以引入体液和试剂的多个比色杯的体液的装置的特征在于包括在顶部开口的腔室的装置，所述腔室的数量至少等于比色皿的数量 。

公开(公告)号：US20090226346A1

公开(公告)日：2009-09-10

申请号：US12442436

申请日：2007-09-21

申请人： Takahiro Miyato ,  Tatsuo Kurosawa ,  Tomohisa Kawabata ,  Masayoshi Hayashi

发明人： Takahiro Miyato ,  Tatsuo Kurosawa ,  Tomohisa Kawabata ,  Masayoshi Hayashi

IPC分类号： B01L3/02

CPC分类号： G01N35/1016 ,  G01N21/11 ,  G01N35/028 ,  G01N2035/1034

摘要： A dispensing device discharges a liquid into a well of a microchip, which includes the well having an opening at the upper end, and a microchannel in fluid communication with the lower end of the well. The well has a bottom portion formed by an annular step portion projecting inward at the lower end. The dispensing device includes: a nozzle having a tip opening for suctioning and discharging a liquid therethrough; a pump for supplying suction pressure and discharge pressure to the nozzle; moving unit for causing relative movement of the nozzle at least in depth direction of the well; and control unit for causing the moving unit to cause the relative movement of the nozzle until the tip opening reaches the bottom portion, and then causing the liquid to be discharged such that the liquid first contacts a bottom surface and/or an inner circumferential surface of the bottom portion.

摘要翻译： 分配装置将液体排放到微芯片的井中，该微芯片包括在上端具有开口的井以及与井的下端流体连通的微通道。 井具有由在下端向内突出的环状台阶部形成的底部。 分配装置包括：喷嘴，其具有用于吸入和排出液体的尖端开口; 用于向喷嘴提供吸入压力和排出压力的泵; 移动单元，用于至少在井的深度方向上引起喷嘴的相对运动; 以及控制单元，用于使所述移动单元引起所述喷嘴的相对运动，直到所述尖端开口到达所述底部部分，然后使所述液体排出，使得所述液体首先接触到所述液体的底表面和/或内周面 底部。

公开(公告)号：US20090188668A1

公开(公告)日：2009-07-30

申请号：US12019452

申请日：2008-01-24

申请人： Rocco DiFoggio

发明人： Rocco DiFoggio

IPC分类号： E21B49/08

CPC分类号： E21B49/10 ,  E21B47/01 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/10 ,  G01J3/44 ,  G01N21/09 ,  G01N21/11 ,  G01N21/3577 ,  G01N21/65 ,  G01N2201/08 ,  G01V8/02

摘要： A downhole fluid sample container includes a fluid sample container detachably coupled to a downhole sub, the fluid sample container having an internal chamber for receiving the downhole fluid. At least one semimetal (for example, silicon or germanium) window is coupled to the fluid sample container, the window being substantially transparent to electromagnetic energy wavelengths within a selected band. A method includes transmitting electromagnetic energy from an electromagnetic energy source to downhole fluid through at least one semimetal window in a container, receiving an electromagnetic energy response with a spectrometer, and estimating the downhole fluid property based at least in part on the electromagnetic energy response.

摘要翻译： 井下流体样品容器包括可拆卸地联接到井下sub的流体样品容器，流体样品容器具有用于接收井下流体的内部室。 至少一个半金属（例如，硅或锗）窗口耦合到流体样品容器，该窗对于选定的带内的电磁能量波长基本上是透明的。 一种方法包括：通过容器中的至少一个半金属窗口将电磁能量从电磁能源传输到井下流体，利用光谱仪接收电磁能量响应，以及至少部分地基于电磁能量响应来估计井下流体特性。