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公开(公告)号：USD1029247S1
公开(公告)日：2024-05-28
申请号：US35517114
申请日：2022-05-10
设计人： Roland Janzen
摘要： The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
1. Pump for liquids
1.1 : Front
1.2 : Top
1.3 : Left
1.4 : Right
1.5 : Bottom
1.6 : Perspective
The claimed design is for the liquid pump which is a cylindrical, orange-colored object and is narrowed in the middle and surrounded by a spiral of metal in the middle; at the upper end, a notch shows, from the middle of which a hexagonal thread protrudes; the underside shows no notch but a closed surface from which metal rollers bulge out at two opposite points; fig. 1.1 is a front view of the liquid pump; fig. 1.2 is a top view of the liquid pump; fig. 1.3. is a left side view of the pump lying lengthwise on the surface so that the metal rollers on the underside can be seen from the side; fig. 1.4 is a right side view of the pump lying lengthwise on the surface so that the metal rollers on the underside can be seen from the front and as recessed half rings; fig. 1.5 is a bottom view of the underside of the pump; fig. 1.6 is an oblique perspective view showing the underside of the pump in the front of the picture.-
22.发明公开公开(公告)号：US20240094198A1
公开(公告)日：2024-03-21
申请号：US18369273
申请日：2023-09-18
发明人： Michel Perbost , Sameh Soliman , Xiao-Pei Guan , Mong Sano Marma
IPC分类号： G01N33/532 , G01N1/44
CPC分类号： G01N33/532 , G01N1/44
摘要： The invention is directed to a method for detecting a target moiety in a sample of biological specimens by the steps
a) providing at least one conjugate with the general formula (I) Xn— P—Ym, with X is a detection moiety, P an acidic or basic degradable spacer and Y an antigen or oligonucleotide recognizing moiety and n, m are integers between 1 and 100 and wherein X and Y are covalently bound to P,
b) binding the conjugate to the target moiety target via the antigen or oligonucleotide recognizing moiety Y, thereby labelling the target moiety,
c) detecting the target moiety labelled with the conjugate by detecting the detecting moiety X,
d) providing at least one precursor which is capable of releasing an acid or base when provided with radiation wherein the acid or base is capable of cleaving P,
e) activating the precursor by providing radiation, thereby releasing the acid or base capable of cleaving P, and
f) degrading spacer P with the released acid or base, thereby cleaving the detection moiety X from the conjugated detection moiety.-
公开(公告)号：US20240068026A1
公开(公告)日：2024-02-29
申请号：US18270873
申请日：2021-01-12
发明人： Rainer PROF UHL
IPC分类号： C12Q1/6874 , G02B21/16 , G02B21/36
CPC分类号： C12Q1/6874 , G02B21/16 , G02B21/361
摘要： The invention is directed to a microscope device comprising a microscope objective (1); one or more light sources; at least 3 dichroic beam sputters (50, 51, 56) and at least 2 cameras (109, 117) characterized in that the light generated by the light source interacts with the sample (3) thereby producing a sample beam (6), wherein—sample beam (6) is divided with a first dichroic beam splitter (50) into beam (K) and beam (L) wherein beam (K) and beam (L) have different spectral ranges of light and wherein—beam (K) is divided with a second dichroic beam splitter (51) into a first beam (A) having a first spectral range of light and a second beam (B) having a second spectral range of light and wherein first beam (A) is guided via reflection element (54) on the detector of the first camera (109) and wherein second beam (B) is guided via reflection elements (52) and (53) on the detector of the first camera (109) and wherein—beam (L) is divided with a third dichroic beam splitter (56) into a third beam (C) having a third spectral range of light and a fourth beam (D) having a fourth spectral range of light and wherein third beam (C) is guided via reflection element (58) and (59) on the detector of the second camera (117) and wherein the fourth beam (D) is guided via reflection element (57) on the detector of the second camera (117). Use of the microscope to obtain sequencing information.
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24.发明授权公开(公告)号：US11866729B2
公开(公告)日：2024-01-09
申请号：US17011746
申请日：2020-09-03
发明人： Andreas Bosio , Andrej Smiyakin
IPC分类号： C12N5/0793 , C12N5/079 , G01N33/569 , A61K35/30
CPC分类号： C12N5/0618 , A61K35/30 , G01N33/56966 , C12N2501/998 , C12N2506/45
摘要： The present invention discloses an in vitro method for the generation of a cell composition comprising or consisting of ventral midbrain dopaminergic progenitor cells from a cell composition comprising pluripotent and/or multipotent stem cells, the method comprising the steps of A) differentiating said pluripotent and/or multipotent stem cells into ventral dopaminergic progenitor cells, thereby generating a cell composition comprising ventral dopaminergic progenitor cells comprising ventral midbrain dopaminergic progenitor cells and ventral hindbrain dopaminergic progenitor cells, and B) Enriching CD117 positive cells from said cell composition comprising ventral dopaminergic progenitor cells by using an antigen binding molecule specific for the CD117 antigen, thereby generating said cell composition comprising or consisting of ventral midbrain dopaminergic progenitor cells. Cell compositions obtainable by said method are also disclosed.
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公开(公告)号：US20230407383A1
公开(公告)日：2023-12-21
申请号：US18210119
申请日：2023-06-15
发明人： Robert Pinard , Seiyu Hosono
IPC分类号： C12Q1/6869 , C12Q1/6862
CPC分类号： C12Q1/6869 , C12Q1/6862
摘要： The invention is directed to a method to simultaneously obtain both the spatial location and sequence information of a target sequence with a higher resolution than the known technologies. The method comprises steps to spatially localize the mRNA expressed on a tissue by the use of a hybrid circular/linear DNA probe with an UMI and—after several amplification steps, the obtaining sequence information by NGS.
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公开(公告)号：US20230241368A1
公开(公告)日：2023-08-03
申请号：US18122753
申请日：2023-03-17
IPC分类号： A61M39/18
CPC分类号： A61M39/18 , A61M2039/1027
摘要： The invention is directed to an connector comprising a first part and a second part, each provided with a contact surface and at least one non-contact surface facing away from the contact surface, at least one opening in the contact surface having an fluid connection to at least one opening of the non-contact surface, a releasable covering of the opening in the contact surface, and complementary means for mechanically coupling the parts at the contact surfaces to form the connector. The complementary means for mechanically coupling the parts are configured to mechanically interlock with each other.
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公开(公告)号：US11701387B2
公开(公告)日：2023-07-18
申请号：US16959330
申请日：2019-01-04
发明人： Rafijul Bari , Markus Granzin , Wing Leung , Andrzej Dzionek , Martin Meyer
IPC分类号： C07K16/46 , A61K35/17 , A61P35/00 , A61K39/395 , C07K16/28
CPC分类号： A61K35/17 , A61K39/3955 , A61P35/00 , C07K16/2851 , C07K2317/73
摘要： The present invention discloses a chimeric antigen receptor (CAR) comprising an antigen binding domain specific for BDCA2, a population of engineered cells expressing said CAR and a pharmaceutical composition thereof. Said engineered cells are for treatment of cancer in a subject, wherein the cancerous cells of said cancer express BDCA2 such as Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN).
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公开(公告)号：US20230176062A1
公开(公告)日：2023-06-08
申请号：US18083279
申请日：2022-12-16
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/034 , B03C1/288 , B03C1/0332 , B03C1/0335 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/10 , B04B5/0442 , B04B7/08 , B04B13/00 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0018 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , B01L3/5021 , B03C2201/18 , B03C2201/26
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US20230138285A1
公开(公告)日：2023-05-04
申请号：US17976933
申请日：2022-10-31
发明人： Thorge Reiber , Dmytro Yushchenko
IPC分类号： G01N33/548 , C08F293/00 , G01N1/30
摘要： The invention is directed to a conjugate characterized by high brightness to enable detection of rarely expressed epitopes and release of the label from the epitope to enable downstream applications such as sequential imaging or cell sorting and with the general formula (I) Yn−P1(P2−Xm)o, with X: detection moiety; P1: first enzymatically degradable spacer; P2: second enzymatically degradable spacer; Y: antigen recognizing moiety and n, m, o integers between 1 and 100 with the provision that first spacer P1 and second spacer P2 are not degradable by the same enzyme.
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30.发明授权公开(公告)号：US11634495B2
公开(公告)日：2023-04-25
申请号：US16603519
申请日：2018-04-06
发明人： Iris Bürger , Martin Meyer , Andrzej Dzionek
IPC分类号： A61K39/395 , C07K16/28 , A61P37/06
摘要： The present invention relates to polypeptides comprising a mutant human IgG4, which mutant human IgG4 is capable of increasing the binding to and activation of immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing FcγRIIb/c (CD32b), but not FcγRIIa (CD32a). More specifically, the invention relates to polypeptides comprising at least one human IgG4 with a lysine at position 409 (409K), using the EU index according to Kabat et al., which IgG4 is capable of binding to human CD32b/c with a statistically significant (p=0.05) higher binding affinity than a wild-type human IgG1 and than a wild-type human IgG4, for use in the prevention and/or treatment of an autoimmune disease or allergy, as further defined in the claims.
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