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21.发明授权Method for modifying the wettability and/or other biocompatibility characteristics of a surface of a biological material by the application of gas cluster ion beam technology and biological materials made thereby 有权通过应用气体簇离子束技术和由此制备的生物材料来改变生物材料表面的润湿性和/或其它生物相容性特征的方法公开(公告)号：US08367092B2
公开(公告)日：2013-02-05
申请号：US12722126
申请日：2010-03-11
Applicant: Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
Inventor： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
IPC: A61K25/12
CPC classification number: A61F2/30771 , A61B2017/00969 , A61F2/0077 , A61F2/08 , A61F2/30767 , A61F2/4644 , A61L27/3604 , A61L27/3691 , A61L27/38 , A61L2430/10 , A61L2430/40 , H01J2237/0812 , H01J2237/20207 , H01J2237/20214
Abstract: The invention provides methods for surgical grafting of a tissue. The method comprises the steps of explanting a graft tissue from a donor, irradiating at least a first portion of the graft tissue with an ion beam, and surgically grafting the graft tissue into a recipient.
Abstract translation: 本发明提供了用于组织外科移植的方法。 该方法包括以下步骤：从供体移出移植物组织，用离子束照射移植组织的至少第一部分，以及将移植物组织手术移植到受体中。
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22.发明申请METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY 有权改善表面表面和物体的生物活性特征的方法改进的表面公开(公告)号：US20110300599A1
公开(公告)日：2011-12-08
申请号：US13101757
申请日：2011-05-05
Applicant: Joseph Khoury , Laurence Berlowitz Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
Inventor： Joseph Khoury , Laurence Berlowitz Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga
CPC classification number: A61L27/18 , A61B2017/00969 , A61L27/38 , A61L2400/18 , A61L2430/10 , A61L2430/40 , H01J37/05 , H01J37/317 , H01J2237/0041 , H01J2237/053 , H01J2237/0812 , H01J2237/0827 , H01J2237/20207 , H01J2237/20214 , C08L71/12 , C08L71/00
Abstract: The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provides a method of attaching cells to an object. The invention even further provides for a method of preparing an object for medical implantation. The invention also provides for an article with attached cell, and for an article for medical implantation. Improvements result from the application of gas-cluster ion beam technology and from the application of neutral beam technology, wherein neutral beams are derived from accelerated gas-cluster ion beams.
Abstract translation: 本发明提供了一种提高可植入物体表面的生物活性的方法。 本发明还提供了一种提高生物实验室器皿表面生物活性的方法。 本发明还提供了将细胞附着到对象的方法。 本发明甚至进一步提供了一种制备用于医学植入的物体的方法。 本发明还提供具有附着细胞的物品和用于医疗植入物品。 改进的结果是应用气体束离子束技术和中性束技术的应用，其中中性束源自加速气体簇离子束。
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23.发明申请Method and System for Improving Surgical Blades by the Application of Gas Cluster Ion Beam Technology and Improved Surgical Blades 审中-公开通过应用气体束离子束技术和改进的手术刀片改进手术刀片的方法和系统公开(公告)号：US20090198264A1
公开(公告)日：2009-08-06
申请号：US12364100
申请日：2009-02-02
Applicant: Richard C. Svrluga , Sean R. Kirkpatrick
Inventor： Richard C. Svrluga , Sean R. Kirkpatrick
CPC classification number: A61B17/3209 , A61B2017/00526 , A61B2017/00831 , C23C14/0641 , C23C14/221 , H01J2237/0812
Abstract: Methods and systems for the improvement of a crystalline and/or poly-crystalline surgical blade include gas cluster ion beam irradiation of the blades in order to smooth; or to sharpen; or to reduce the brittleness and thus reduce susceptibility of the blade to crack, chip, or fracture; or to render the blades hydrophilic. Crystalline or poly-crystalline surgical blade (silicon for example) having a thin film cutting edge with improved properties.
Abstract translation: 用于改善结晶和/或多晶外科手术刀片的方法和系统包括叶片的气体簇离子束照射以平滑; 或锐化 或降低脆性，从而降低刀片的裂纹，碎裂或断裂的敏感性; 或使刮片呈亲水性。 具有提高性能的薄膜切割边缘的结晶或多晶外科刀片（例如硅）。
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24.发明申请公开(公告)号：US20090074834A1
公开(公告)日：2009-03-19
申请号：US12210018
申请日：2008-09-12
Applicant: Sean R. Kirkpatrick , Richard C. Svrluga
Inventor： Sean R. Kirkpatrick , Richard C. Svrluga
IPC: A61K9/00
CPC classification number: B05D3/068 , B05D3/104 , B05D5/00 , H01J2237/0812
Abstract: Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas cluster ion beam. Improvements in wettability of a surface by the invention exceed those obtained by conventional plasma cleaning or etching. The improvements may be applied to surfaces of medical devices, such as vascular stents for example, and may be used to enable better wetting of medical device surfaces with liquid drugs in preparation for adhesion of the drug to the device surfaces. A mask may be used to limit processing to a portion of the surface. Medical devices formed by using the methods of the invention are disclosed.
Abstract translation: 用气体簇离子束照射材料的表面改变了表面的润湿性。 根据气体簇离子束的特性，润湿性可以增加或减少。 通过本发明的表面润湿性的改善超过了通过常规等离子体清洗或蚀刻获得的那些。 这些改进可以应用于诸如血管支架的医疗装置的表面，并且可以用于使液体药物更好地润湿医疗装置表面，以准备将药物粘附到装置表面。 可以使用掩模来将处理限制到表面的一部分。 公开了通过使用本发明的方法形成的医疗装置。
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25.发明授权公开(公告)号：US10202684B2
公开(公告)日：2019-02-12
申请号：US14466242
申请日：2014-08-22
Applicant: Sean R. Kirkpatrick , Allen R. Kirkpatrick , Michael J. Walsh
Inventor： Sean R. Kirkpatrick , Allen R. Kirkpatrick , Michael J. Walsh
IPC: C23C14/58 , H01J37/32 , G02B1/12 , G02B1/02 , H01J37/05 , H01J37/317 , H01J37/147
Abstract: A method for Neutral Beam irradiation derived from gas cluster ion beams and articles produced thereby including optical elements.
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Patent Agency Ranking
公开(公告)号：US10181402B2
公开(公告)日：2019-01-15
申请号：US15047553
申请日：2016-02-18
Applicant: Sean R. Kirkpatrick , Allen R. Kirkpatrick , Michael J. Walsh , Richard C. Svrluga
Inventor： Sean R. Kirkpatrick , Allen R. Kirkpatrick , Michael J. Walsh , Richard C. Svrluga
IPC: H01L29/167 , H01J37/05 , H01L21/265 , H01J37/08 , H01J37/147 , H01J37/317
Abstract: A method of treating a surface of a silicon substrate forms an accelerated gas cluster ion beam of carbon atoms, promotes fragmentation and/or dissociation of gas cluster ions in the beam, removes charged particles from the beam to form a neutral beam, and treats a portion of a surface of the silicon substrate by irradiating it with the neutral beam. A silicon substrate surface layer of SiCX (0.05
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公开(公告)号：US20170290960A1
公开(公告)日：2017-10-12
申请号：US15624381
申请日：2017-06-15
Applicant: Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
Inventor： Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
CPC classification number: A61L31/16 , A61L31/10 , A61L2300/602 , A61L2300/606 , A61L2420/02 , B05D1/02 , B05D3/068
Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.
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28.发明申请METHOD AND APPARATUS FOR NEUTRAL BEAM PROCESSING BASED ON GAS CLUSTER ION BEAM TECHNOLOGY AND ARTICLES PRODUCED THEREBY 审中-公开基于气体离子束技术的中性光束处理方法与装置及其制作方法公开(公告)号：US20160172197A1
公开(公告)日：2016-06-16
申请号：US15047553
申请日：2016-02-18
Applicant: Sean R. Kirkpatrick , Allen R. Kirkpatrick , Michael J. Walsh , Richard C. Svrluga
Inventor： Sean R. Kirkpatrick , Allen R. Kirkpatrick , Michael J. Walsh , Richard C. Svrluga
IPC: H01L21/265 , H01L29/167
CPC classification number: H01L21/2652 , C03C23/005 , C03C2204/08 , H01J37/05 , H01J37/08 , H01J37/147 , H01J37/317 , H01J37/3171 , H01J2237/0041 , H01J2237/0812 , H01J2237/15 , H01J2237/31701 , H01L21/02115 , H01L21/02238 , H01L21/02274 , H01L21/26506 , H01L21/26513 , H01L21/26566 , H01L21/31116 , H01L21/32115 , H01L21/324 , H01L29/167 , H01L29/36 , Y10T428/24355 , Y10T428/24479 , Y10T428/30
Abstract: A method for treating a silicon substrate, and a silicon substrate, provide a surface treated with an accelerated neutral beam.
Abstract translation: 用于处理硅衬底和硅衬底的方法提供用加速中性束处理的表面。
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公开(公告)号：US20160091787A1
公开(公告)日：2016-03-31
申请号：US14892284
申请日：2014-05-21
Applicant: Sean R. KIRKPATRICK , Son CHAU , EXOGENESIS CORPORATION
Inventor： Sean R. Kirkpatrick , Son T. Chau
Abstract: A film and method of forming a film provides an unmodified starting layer of a starting material, the starting layer having opposed first and second surfaces and an initial thickness, T1, and a modified surface layer of thickness T2 which is less than T1, formed in at least a portion of the second surface, wherein a portion of the modified surface layer is not supported by unmodified starting material removed from the first surface opposite the modified surface layer.
Abstract translation: 薄膜和薄膜的形成方法提供了未改性的原料起始层，起始层具有相对的第一和第二表面，初始厚度T1和厚度T2小于T1的改性表面层形成于 所述第二表面的至少一部分，其中所述改性表面层的一部分不被从所述改性表面层相对的所述第一表面除去的未改性起始材料支撑。
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30.发明申请METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY 审中-公开改善表面表面和物体的生物活性特征的方法改进的表面公开(公告)号：US20140336125A1
公开(公告)日：2014-11-13
申请号：US14368972
申请日：2012-12-18
Applicant: Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Kshama J. Doshi
Inventor： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Kshama J. Doshi
Abstract: A method for improving bioactivity and/or biodegradation time of a collagen surgical implant and collagen surgical implants having such improved properties. A gas-cluster ion-beam (GCIB) is formed in a reduced-pressure chamber, a collagen surgical implant is introduced into the reduced-pressure chamber, and at least a first portion of the surface of said collagen surgical implant is irradiated with a GCIB-derived beam.
Abstract translation: 一种用于改善具有这种改善的性质的胶原手术植入物和胶原外科植入物的生物活性和/或生物降解时间的方法。 在减压室中形成气体簇离子束（GCIB），将胶原外科植入物引入减压室中，并且将所述胶原外科植入物的表面的至少第一部分用 GCIB衍生光束。
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