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公开(公告)号：US20160160187A1
公开(公告)日：2016-06-09
申请号：US15046011
申请日：2016-02-17
申请人： CODEXIS, INC.
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12N9/0008 , C12P7/28 , C12P13/02 , C12P17/02 , C12Y101/01184
摘要： The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides
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公开(公告)号：US09121045B2
公开(公告)日：2015-09-01
申请号：US14504558
申请日：2014-10-02
申请人： Codexis, Inc.
CPC分类号： C12N9/001 , C07K2319/00 , C12N9/0036 , C12N15/00 , C12P7/24 , C12P7/26 , C12P7/52 , C12P7/62 , C12P13/002 , C12Y103/01031 , C12Y106/99001 , Y02P20/52
摘要： The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
摘要翻译： 本公开涉及具有改进性质的工程化烯酮还原酶多肽，编码工程改造多肽的多核苷酸，相关载体，宿主细胞和用于制备工程化烯酮还原酶多肽的方法。 本公开还提供了使用工程化烯酮还原酶多肽进行化学转化的方法。
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公开(公告)号：US09080163B2
公开(公告)日：2015-07-14
申请号：US14274589
申请日：2014-05-09
申请人： Codexis, Inc.
CPC分类号： C12N9/2437 , C12N15/52 , C12N15/80 , C12N15/81 , C12P7/04 , C12P7/10 , C12P19/02 , C12P19/14 , C12P2203/00 , Y02E50/16
摘要： The invention relates to recombinant expression of variant forms of C1 CBH1a and homologs thereof, having improved thermostability, low-pH tolerance, specific activity and other desirable properties. Also provided are methods for producing ethanol and other valuable organic compounds by combining cellobiohydrolase variants with cellulosic materials.
摘要翻译： 本发明涉及C1 CBH1a及其同系物的变体形式的重组表达，具有改善的热稳定性，低pH耐受性，比活性和其它所需性质。 还提供了通过将纤维二糖水解酶变体与纤维素材料结合来生产乙醇和其它有价值的有机化合物的方法。
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公开(公告)号：US20150087028A1
公开(公告)日：2015-03-26
申请号：US14384133
申请日：2013-03-12
申请人： Codexis, Inc.
发明人： Behnaz Behrouzian , Xinkai Xie , Kui Chan , Xiyun Zhang , Vesna Mitchell , Douglas A. Hattendorf
CPC分类号： C12P19/14 , C12N9/2434 , C12N9/2437 , C12P7/04 , C12P7/10 , C12P7/18 , C12P7/20 , C12P7/40 , C12P13/001 , C12P19/02 , C12P2203/00 , C12Y302/01091 , C13K1/02 , Y02E50/16
摘要： The invention relates to recombinant expression of variant forms of M. thermophila CBH1a and homologs thereof, having improved thermoactivity, specific activity, and other desirable properties. Also provided are methods for producing ethanol and other valuable organic compounds by combining cellobiohydrolase variants with cellulosic materials.
摘要翻译： 本发明涉及具有改进的热活性，比活性和其它所需性质的嗜热绵羊杆菌CBH1a及其同源物的变体形式的重组表达。 还提供了通过将纤维二糖水解酶变体与纤维素材料结合来生产乙醇和其它有价值的有机化合物的方法。
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25.发明申请公开(公告)号：US20140308732A1
公开(公告)日：2014-10-16
申请号：US14313465
申请日：2014-06-24
申请人： Codexis, Inc.
IPC分类号： C12N9/02
CPC分类号： C12N9/0006 , C12N9/0008 , C12P7/28 , C12P13/02 , C12P17/02 , C12Y101/01184
摘要： The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides
摘要翻译： 本公开涉及工程化酮还原酶多肽及其用于从α-氯代酮制备α-氯代醇的用途。 还提供了编码工程化酮还原酶多肽和能够表达工程化酮还原酶多肽的宿主细胞的多核苷酸
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公开(公告)号：US12110493B2
公开(公告)日：2024-10-08
申请号：US17490215
申请日：2021-09-30
申请人： Codexis, Inc.
发明人： Scott J. Novick , Nikki Dellas , Vesna Mitchell , Da Duan , Jovana Nazor , Oscar Alvizo , Auric Anthony Sowell-Kantz , Jeffrey C. Moore , Mark A. Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Nicholas M. Marshall , Jay H. Russell , Keith A. Canada
IPC分类号： C12N15/63
CPC分类号： C12N15/63 , C12Y204/02001
摘要： The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US11807874B2
公开(公告)日：2023-11-07
申请号：US17672542
申请日：2022-02-15
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
CPC分类号： C12N9/0071 , C07K14/80 , C12N9/0042 , C12P13/001 , C12Y114/14001 , C12Y106/02004
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US11795445B2
公开(公告)日：2023-10-24
申请号：US17316165
申请日：2021-05-10
申请人： Codexis, Inc.
发明人： Scott J. Novick , Xiang Yi , Nikki Dellas , Oscar Alvizo , Jovana Nazor , Da Duan , Vesna Mitchell , Jonathan Vroom , Santhosh Sivaramakrishnan , Nandhitha Subramanian , Jeffrey C. Moore , Mark Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Grant S. Murphy , Nicholas Marshall , Jay Russell , Keith A. Canada
CPC分类号： C12N9/90 , C12N15/52 , C12N15/74 , C12N15/815 , C12Y504/02007
摘要： The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20230227805A1
公开(公告)日：2023-07-20
申请号：US18158339
申请日：2023-01-23
申请人： Codexis, Inc.
发明人： Oscar Alvizo , David Elgart , Robert Kevin Orr , James Nicholas Riggins , Anna Fryszkowska , Katrina W. Lexa , Xiang Yi , Da Duan , Courtney Dianne Moffett , Nikki Dellas , Vesna Mitchell
CPC分类号： C12N9/84 , C07K14/62 , C12P21/02 , C12Y305/01011 , C07K2319/21
摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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公开(公告)号：US11591578B2
公开(公告)日：2023-02-28
申请号：US17203421
申请日：2021-03-16
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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