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公开(公告)号：US20240182954A1
公开(公告)日：2024-06-06
申请号：US18352080
申请日：2023-07-13
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. KARTALOV , Aditya RAJAGOPAL , Axel SCHERER
IPC: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/64 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10
CPC classification number: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/6486 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10 , G06F17/10
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US20210169441A1
公开(公告)日：2021-06-10
申请号：US16927911
申请日：2020-07-13
Applicant: California Institute of Technology
Inventor： Aditya RAJAGOPAL , Alaina Ann Brinley RAJAGOPAL
IPC: A61B7/04 , A61B5/0205 , A61B8/00 , A61B5/00 , G01S15/89
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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公开(公告)号：US20150299757A1
公开(公告)日：2015-10-22
申请号：US14753741
申请日：2015-06-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya RAJAGOPAL , Axel SCHERER , Michael D. HENRY , Sameer WALAVALKAR , Thomas A. TOMBRELLO , Andrew P. HOMYK
IPC: C12Q1/02
CPC classification number: C12Q1/02 , A61B5/04001 , G01N27/3275 , G01N27/4146 , G01R1/06711 , G01R1/07342 , H01L29/413 , H01L29/42376 , H01L29/4966 , H01L29/66477 , H01L29/78 , H01L29/7831
Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.
Abstract translation: 本文公开的探针的基本结构和功能允许灵活地并入到探针中，用于各种感测应用的各种感测元件。 这些各种感测应用中的两个示例应用包括生物感测和化学感测应用。 对于生物感测应用，制造在硅衬底上的探针包括诸如纳米柱晶体管的生物感测元件，并且对于化学感测应用，探针包括具有功能化接触区域的感测元件， 当暴露于感兴趣的一种或多种化学品时，感测元件产生电压。
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24.发明申请NANOPILLAR FIELD-EFFECT AND JUNCTION TRANSISTORS WITH FUNCTIONALIZED GATE AND BASE ELECTRODES 有权具有功能门和基极的NANOPILLAR场效应和结晶晶体管公开(公告)号：US20140030819A1
公开(公告)日：2014-01-30
申请号：US13941295
申请日：2013-07-12
Applicant: SANOFI , CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya RAJAGOPAL , Chieh-feng CHANG , Oliver PLETTENBURG , Stefan PETRY , Axel SCHERER , Charles L. TSCHIRHART
CPC classification number: H01L29/413 , B82Y15/00 , G01N27/4145 , G01N27/4146 , H01L29/0676 , H01L29/45 , H01L29/49 , H01L29/73 , H01L29/732 , H01L29/735 , H01L29/78
Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.
Abstract translation: 描述了用于分子感测的系统和方法。 描述了基于场效应或双极结型晶体管的分子传感器。 这些晶体管具有纳米柱，其具有与基极或栅电极接触的官能化层。 功能层可以结合分子，导致传感器中的电信号。
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公开(公告)号：US20140026413A1
公开(公告)日：2014-01-30
申请号：US14038702
申请日：2013-09-26
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Aditya RAJAGOPAL , Axel SCHERER
IPC: H05K3/10
CPC classification number: H05K3/10 , B01L3/502707 , B01L3/502715 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , H01L23/473 , H01L2924/0002 , H05K1/0272 , H05K3/284 , H05K2201/10189 , H05K2203/1327 , Y10T29/49 , Y10T29/49002 , Y10T29/49155 , Y10T29/49165 , Y10T137/85938 , Y10T436/11 , Y10T436/25 , Y10T436/2575 , H01L2924/00
Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.
Abstract translation: 印刷电路板结构涂覆有已经形成微流体通道的密封剂。 在封装之前，通过将流体连接焊接到印刷电路板结构的表面上的金属迹线来形成微流体通道。 在封装后通过蚀刻去除金属迹线，以在密封剂内形成微通道。
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Patent Agency Ranking
公开(公告)号：US20250084463A1
公开(公告)日：2025-03-13
申请号：US18893086
申请日：2024-09-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. KARTALOV , Aditya RAJAGOPAL , Axel SCHERER
IPC: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/64 , G06F17/10 , G06F17/11 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/00 , G16B40/10
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US20240093273A1
公开(公告)日：2024-03-21
申请号：US18516842
申请日：2023-11-21
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. KARTALOV , Aditya RAJAGOPAL , Axel SCHERER
IPC: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/64 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10
CPC classification number: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/6486 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10 , G06F17/10
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US20180317877A1
公开(公告)日：2018-11-08
申请号：US16038070
申请日：2018-07-17
Applicant: California Institute of Technology
Inventor： Aditya RAJAGOPAL , Alaina Ann Brinley RAJAGOPAL
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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公开(公告)号：US20180049716A1
公开(公告)日：2018-02-22
申请号：US15678789
申请日：2017-08-16
Applicant: California Institute of Technology
Inventor： Aditya RAJAGOPAL , Alaina Ann Brinley RAJAGOPAL
IPC: A61B7/04 , A61B5/0205 , A61B8/00 , A61B5/00
CPC classification number: A61B7/04 , A61B5/0022 , A61B5/02055 , A61B5/021 , A61B5/0816 , A61B5/14532 , A61B5/14542 , A61B5/7253 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B5/742 , A61B8/4477 , A61B2560/0214
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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30.发明申请NANOPILLAR FIELD-EFFECT AND JUNCTION TRANSISTORS WITH FUNCTIONALIZED GATE AND BASE ELECTRODES 有权具有功能门和基极的NANOPILLAR场效应和结晶晶体管公开(公告)号：US20150279948A1
公开(公告)日：2015-10-01
申请号：US14720429
申请日：2015-05-22
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SANOFI
Inventor： Aditya RAJAGOPAL , Chieh-feng CHANG , Oliver PLETTENBURG , Stefan PETRY , Axel SCHERER , Charles L. TSCHIRHART
IPC: H01L29/41 , H01L29/735 , H01L29/78 , H01L29/49 , H01L29/45
CPC classification number: H01L29/413 , B82Y15/00 , G01N27/4145 , G01N27/4146 , H01L29/0676 , H01L29/45 , H01L29/49 , H01L29/73 , H01L29/732 , H01L29/735 , H01L29/78
Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.
Abstract translation: 描述了用于分子感测的系统和方法。 描述了基于场效应或双极结型晶体管的分子传感器。 这些晶体管具有纳米柱，其具有与基极或栅电极接触的官能化层。 功能层可以结合分子，导致传感器中的电信号。
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