公开(公告)号：US20220380509A1

公开(公告)日：2022-12-01

申请号：US17870329

申请日：2022-07-21

Applicant: Alcon Inc.

Inventor： Jinyu Huang ,  Frank Chang ,  Steve Yun Zhang ,  Feng Jing

IPC: C08F290/06 ,  G02B1/04 ,  C08G77/20 ,  C08G77/16 ,  C08G77/392

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

公开(公告)号：US20210130644A1

公开(公告)日：2021-05-06

申请号：US17148197

申请日：2021-01-13

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Feng Jing ,  Troy Vernon Holland ,  Chung-Yuan Chiang ,  John Dallas Pruitt

IPC: C09D133/26 ,  C08L33/26 ,  C08L79/02 ,  C09D179/02 ,  C08F220/28 ,  C08F220/38 ,  C08F220/56 ,  C09D5/02 ,  C09D133/14 ,  C09D179/08 ,  G02B1/04

Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

公开(公告)号：US20210011197A1

公开(公告)日：2021-01-14

申请号：US17038266

申请日：2020-09-30

Applicant: Alcon Inc.

Inventor： Daqing Wu ,  Junhao Ge ,  Steve Yun Zhang ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: G02B1/04 ,  C08L83/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US20210009743A1

公开(公告)日：2021-01-14

申请号：US17038349

申请日：2020-09-30

Applicant: Alcon Inc.

Inventor： Jinyu Huang ,  Frank Chang ,  Steve Yun Zhang ,  Feng Jing

IPC: C08F290/06 ,  G02B1/04 ,  C08G77/20 ,  C08G77/16 ,  C08G77/392

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

公开(公告)号：US20240293985A1

公开(公告)日：2024-09-05

申请号：US18586910

申请日：2024-02-26

Applicant: Alcon Inc.

Inventor： Richard Charles Breitkopf ,  Feng Jing ,  Daqing Wu ,  Jack W. Trieu ,  Steve Yun Zhang

IPC: B29D11/00 ,  B29C33/40 ,  B29C35/02 ,  B29K83/00 ,  B29K105/00 ,  B29K105/16 ,  G02C7/04

CPC classification number: B29D11/00865 ,  B29C33/40 ,  B29C35/0227 ,  B29D11/00067 ,  B29D11/00125 ,  B29K2083/00 ,  B29K2105/0002 ,  B29K2105/0061 ,  B29K2105/16 ,  B29K2823/12 ,  B29K2995/0093 ,  G02C7/049

Abstract: The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner. The method comprises treating the molding surfaces of polypropylene lens molds (or other hydrophobic plastic molds) with a vacuum UV or a corona plasma to increase the surface energies of the molding surfaces of the lens molds, cast-molding a silicone hydrogel lens formulation containing a relatively small amount of at least one carboxyl-containing vinylic monomer in the treated lens molds, and heating resultant cast-molded silicone hydrogel contact lenses in an aqueous coating solution comprising a water-soluble and thermally crosslinkable polymeric material to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel layer covalently attached onto the bulk silicone hydrogel material.

公开(公告)号：US20230382065A1

公开(公告)日：2023-11-30

申请号：US18322651

申请日：2023-05-24

Applicant: Alcon Inc.

Inventor： Jing Cheng ,  Michelle Plavnik ,  Ya-Wen Chang ,  Feng Jing ,  Steve Yun Zhang

IPC: B29D11/00

CPC classification number: B29D11/00134 ,  B29D11/00442 ,  B29D11/0048

Abstract: A method for producing embedded hydrogel contact lenses comprises at least the following steps: obtaining an insert made of a crosslinked polymeric material comprising repeating units of a free-radical photoinitiator; placing the insert in a female lens mold half; dosing an amount of a lens-forming composition to immerse the insert in the female lens mold half; closing tightly a male lens mold half onto the top of the female lens mold half halves to form a molding assembly; actinically curing both the lens-forming composition in the molding assembly to form an embedded hydrogel lens precursor which comprises a bulk hydrogel material formed the lens-forming composition and the insert that is embedded therein and covalently linked to the bulk hydrogel material.

公开(公告)号：US20230103231A1

公开(公告)日：2023-03-30

申请号：US17823539

申请日：2022-08-31

Applicant: Alcon Inc.

Inventor： Daqing Wu ,  Feng Jing ,  Steve Yun Zhang ,  Junhao Ge ,  Jack W. Trieu

IPC: G02B1/04 ,  G02B1/14 ,  B29D11/00

Abstract: The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermally or actinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C1-C2 alkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and/or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.

公开(公告)号：US11453736B2

公开(公告)日：2022-09-27

申请号：US17038349

申请日：2020-09-30

Applicant: Alcon Inc.

Inventor： Jinyu Huang ,  Frank Chang ,  Steve Yun Zhang ,  Feng Jing

IPC: C08L101/14 ,  C08L83/04 ,  C08F290/06 ,  G02B1/04 ,  C08G77/20 ,  C08G77/16 ,  C08G77/392 ,  C08G77/12

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

公开(公告)号：US20220275154A1

公开(公告)日：2022-09-01

申请号：US17742559

申请日：2022-05-12

Applicant: Alcon Inc.

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Junhao Ge ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G77/14 ,  C08L83/10 ,  G02B1/04 ,  C08G77/12 ,  B29D11/00 ,  G02C7/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US11346982B2

公开(公告)日：2022-05-31

申请号：US17038266

申请日：2020-09-30

Applicant: Alcon Inc.

Inventor： Daqing Wu ,  Junhao Ge ,  Steve Yun Zhang ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: G02B1/04 ,  C08L83/04 ,  C08F230/08 ,  B29D11/00

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.