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    Method for determining coating thickness on coated contact lenses
    1.
    发明授权
    Method for determining coating thickness on coated contact lenses 有权

    公开(公告)号：US11927512B2

    公开(公告)日：2024-03-12

    申请号：US17087983

    申请日：2020-11-03

    Applicant: Alcon Inc.

    Inventor： Yuan Chang ,  Ying Zheng ,  Junhao Ge ,  Steve Yun Zhang ,  Karen Belinda Sentell ,  Jinbo Dou

    IPC: G01N1/30 ,  G01N1/04 ,  G01N21/77 ,  G02B1/04

    CPC classification number: G01N1/30 ,  G01N1/04 ,  G01N21/77 ,  G02B1/043 ,  G01N2001/302 ,  G01N2021/7786

    Abstract: The invention provides a method for imaging and thickness determination of coatings on coated contact lenses. The method comprises selectively staining a negatively-charged-groups-containing coating over the lens body of a coated contact lens by immersing the coated contact lens in an aqueous solution comprising a fluorescently-labeled polycationic polymer and having a pH of from about 6.5 to 8.0; orthogonally cutting the selectively-stained coated contact lens; and determining the thickness of the coating on the coated contact lens. In addition, the invention provides a method for selecting a candidate coating material comprising negatively charged groups for applying a coating with a desired thickness onto silicone hydrogel contact lenses and for optimizing a coating process for producing coated silicone hydrogel contact lenses with a desired thickness coating thereon.

    METHOD FOR DETERMINING COATING THICKNESS ON COATED CONTACT LENSES
    3.
    发明申请
    METHOD FOR DETERMINING COATING THICKNESS ON COATED CONTACT LENSES 有权

    公开(公告)号：US20210131923A1

    公开(公告)日：2021-05-06

    申请号：US17087983

    申请日：2020-11-03

    Applicant: Alcon Inc.

    Inventor： Yuan Chang ,  Ying Zheng ,  Junhao Ge ,  Steve Yun Zhang ,  Karen Belinda Sentell ,  Jinbo Dou

    IPC: G01N1/30 ,  G02B1/04 ,  G01N1/04 ,  G01N21/77

    Abstract: The invention provides a method for imaging and thickness determination of coatings on coated contact lenses. The method comprises selectively staining a negatively-charged-groups-containing coating over the lens body of a coated contact lens by immersing the coated contact lens in an aqueous solution comprising a fluorescently-labeled polycationic polymer and having a pH of from about 6.5 to 8.0; orthogonally cutting the selectively-stained coated contact lens; and determining the thickness of the coating on the coated contact lens. In addition, the invention provides a method for selecting a candidate coating material comprising negatively charged groups for applying a coating with a desired thickness onto silicone hydrogel contact lenses and for optimizing a coating process for producing coated silicone hydrogel contact lenses with a desired thickness coating thereon.

    Method for preparing silicone hydrogels
    8.
    发明授权
    Method for preparing silicone hydrogels 有权

    公开(公告)号：US11433629B2

    公开(公告)日：2022-09-06

    申请号：US16429776

    申请日：2019-06-03

    Applicant: Alcon Inc.

    Inventor： Weihong Lang ,  Wei Liang ,  Ying Zheng ,  Karen Belinda Sentell ,  Richard Charles Breitkopf ,  Daqing Wu ,  Steve Yun Zhang

    IPC: B29D11/00 ,  G02B1/04 ,  B29K83/00 ,  B29K105/00

    Abstract: The invention provides a contact lens manufacturing method for cast-molding of silicone hydrogel contact lenses having enhanced oxygen permeability without adversely affecting desirable lens mechanical properties (e.g., modulus). A method of the invention comprises adding a small amount of a radical scavenger (e.g., H-TEMPO) in a polymerizable composition for cast-molding of SiHy contact lenses) to provide the resultant polymerizable composition with a bi-phase curing profile at a curing temperature of from about 45° C. to about 100° C. With such a bi-phase curing profile, the resultant polymerizable composition can be thermally cured at the curing temperature to form a SiHy contact lens having an oxygen permeability higher than that for a polymerizable composition having the substantially identical composition excepting being free of any radical scavenger.

    Wettable silicone hydrogel contact lenses
    10.
    发明授权
    Wettable silicone hydrogel contact lenses 有权

    公开(公告)号：US11513257B2

    公开(公告)日：2022-11-29

    申请号：US17122109

    申请日：2020-12-15

    Applicant: Alcon Inc.

    Inventor： Ying Zheng ,  Jang-Shing Chiou ,  Jinbo Dou ,  Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang ,  Li Yao ,  Karen Belinda Sentell ,  Ye Hong

    IPC: C08L39/06 ,  G02B1/04 ,  B65B25/00 ,  C08L71/02 ,  C08L83/04 ,  G02C7/04

    Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.

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