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公开(公告)号：US20210181379A1
公开(公告)日：2021-06-17
申请号：US17122109
申请日：2020-12-15
Applicant: Alcon Inc.
Inventor： Ying Zheng , Jang-Shing Chiou , Jinbo Dou , Yuan Chang , Junhao Ge , Steve Yun Zhang , Li Yao , Karen Belinda Sentell , Ye Hong
Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.
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公开(公告)号：US20240207173A1
公开(公告)日：2024-06-27
申请号：US18536388
申请日：2023-12-12
Applicant: Alcon Inc.
Inventor： Adam C. Reboul , Katily Ramirez , Ye Hong , Qiaozhi Lu
CPC classification number: A61K9/0051 , A61K47/10 , A61K47/32 , A61K47/36
Abstract: Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye. These inserts may contain one or more mucoadhesive polymers, a sodium alginate as well as at least one humectant so that, when inserted into the eye, they may absorb tears, and dissolve and slowly release lubricant into the tear film to lubricate and protect the ocular surface for an extended duration of time. The sodium alginate containing eye insert may vary dissolution time on the ocular surface for a longer lasting relief, may reduce dosing frequency and patient burden typically associated with topical drop usage. These polymeric eye inserts also may include one or more pharmaceutically active agents.
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公开(公告)号：US20240207174A1
公开(公告)日：2024-06-27
申请号：US18536437
申请日：2023-12-12
Applicant: Alcon Inc.
Inventor： Adam C. Reboul , Katily Ramirez , Ye Hong , Qiaozhi Lu
IPC: A61K9/00 , A61K31/08 , A61K31/225 , A61K31/355 , A61K47/32 , A61K47/36
CPC classification number: A61K9/0051 , A61K31/08 , A61K31/225 , A61K31/355 , A61K47/32 , A61K47/36
Abstract: Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye. The polymeric eye insert comprises at least one monovalent alginate layer and at least one multivalent salt layer. The at least one monovalent alginate layer is substantially free of the multivalent salt, and the at least multivalent salt layer is substantially free of the monovalent alginate.
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公开(公告)号：US11513257B2
公开(公告)日：2022-11-29
申请号：US17122109
申请日：2020-12-15
Applicant: Alcon Inc.
Inventor： Ying Zheng , Jang-Shing Chiou , Jinbo Dou , Yuan Chang , Junhao Ge , Steve Yun Zhang , Li Yao , Karen Belinda Sentell , Ye Hong
Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.
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