公开(公告)号：US20240207174A1

公开(公告)日：2024-06-27

申请号：US18536437

申请日：2023-12-12

申请人： Alcon Inc.

发明人： Adam C. Reboul ,  Katily Ramirez ,  Ye Hong ,  Qiaozhi Lu

IPC分类号： A61K9/00 ,  A61K31/08 ,  A61K31/225 ,  A61K31/355 ,  A61K47/32 ,  A61K47/36

CPC分类号： A61K9/0051 ,  A61K31/08 ,  A61K31/225 ,  A61K31/355 ,  A61K47/32 ,  A61K47/36

摘要： Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye. The polymeric eye insert comprises at least one monovalent alginate layer and at least one multivalent salt layer. The at least one monovalent alginate layer is substantially free of the multivalent salt, and the at least multivalent salt layer is substantially free of the monovalent alginate.

公开(公告)号：US20240207173A1

公开(公告)日：2024-06-27

申请号：US18536388

申请日：2023-12-12

申请人： Alcon Inc.

发明人： Adam C. Reboul ,  Katily Ramirez ,  Ye Hong ,  Qiaozhi Lu

IPC分类号： A61K9/00 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36

CPC分类号： A61K9/0051 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36

摘要： Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye. These inserts may contain one or more mucoadhesive polymers, a sodium alginate as well as at least one humectant so that, when inserted into the eye, they may absorb tears, and dissolve and slowly release lubricant into the tear film to lubricate and protect the ocular surface for an extended duration of time. The sodium alginate containing eye insert may vary dissolution time on the ocular surface for a longer lasting relief, may reduce dosing frequency and patient burden typically associated with topical drop usage. These polymeric eye inserts also may include one or more pharmaceutically active agents.